S22AH_RAT
ID S22AH_RAT Reviewed; 520 AA.
AC Q9P290; Q4KLP1;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Solute carrier family 22 member 17;
DE AltName: Full=24p3 receptor;
DE Short=24p3R;
DE AltName: Full=Brain-type organic cation transporter;
DE AltName: Full=Lipocalin-2 receptor;
GN Name=Slc22a17; Synonyms=Boct, Boit;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Yaoi T., Fushiki S.;
RT "Human potent organic ion transporter exclusively expressed in brain.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role
CC in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-
CC 24p3), followed by internalization of holo-24p3 and release of iron,
CC thereby increasing intracellular iron concentration and leading to
CC inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed
CC by internalization of apo-24p3 and its association with an
CC intracellular siderophore, leading to iron chelation and iron transfer
CC to the extracellular medium, thereby reducing intracellular iron
CC concentration and resulting in apoptosis (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Upon LCN2-binding, it is
CC internalized. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in brain.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC -!- CAUTION: Was originally (Ref.1) thought to originate from human.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA94604.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB040056; BAA94604.1; ALT_FRAME; mRNA.
DR EMBL; BC099072; AAH99072.1; -; mRNA.
DR EMBL; CH474049; EDM14202.1; -; Genomic_DNA.
DR RefSeq; NP_803156.2; NM_177421.3.
DR RefSeq; XP_006252027.1; XM_006251965.1.
DR AlphaFoldDB; Q9P290; -.
DR SMR; Q9P290; -.
DR STRING; 10116.ENSRNOP00000021851; -.
DR GlyGen; Q9P290; 2 sites.
DR PhosphoSitePlus; Q9P290; -.
DR PaxDb; Q9P290; -.
DR PRIDE; Q9P290; -.
DR GeneID; 305886; -.
DR KEGG; rno:305886; -.
DR UCSC; RGD:631405; rat.
DR CTD; 51310; -.
DR RGD; 631405; Slc22a17.
DR VEuPathDB; HostDB:ENSRNOG00000016414; -.
DR eggNOG; KOG0255; Eukaryota.
DR HOGENOM; CLU_001265_33_6_1; -.
DR InParanoid; Q9P290; -.
DR OMA; HHVIYSS; -.
DR OrthoDB; 1032137at2759; -.
DR PhylomeDB; Q9P290; -.
DR TreeFam; TF335753; -.
DR Reactome; R-RNO-917937; Iron uptake and transport.
DR PRO; PR:Q9P290; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Proteomes; UP000234681; Chromosome 15.
DR Bgee; ENSRNOG00000016414; Expressed in frontal cortex and 19 other tissues.
DR Genevisible; Q9P290; RN.
DR GO; GO:0031301; C:integral component of organelle membrane; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISS:UniProtKB.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0015891; P:siderophore transport; ISS:UniProtKB.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Iron; Iron transport; Membrane;
KW Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport; Vacuole.
FT CHAIN 1..520
FT /note="Solute carrier family 22 member 17"
FT /id="PRO_0000220508"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 520 AA; 55801 MW; 793C45649EFA3312 CRC64;
MASDPIFTLA PPLHCHYGAL PPNASGWEQP PNSSGVSVAG AALAASAASR VVTSTDPSCS
GFAPPDFNHC LKDWDYNGLP VLTTNAIGQW DLVCDLGWQV ILEQILFILG FASGYLFLGY
PADRFGRRGI VLLTLGLVGP CGVGGAAAGS STGIMTLRFL LGFLLAGVDL GVYLMRLELC
DPTQRLRVAL AGELVGVGGH FLFLGLALVS KDWRFLQRMI TAPCILFLFY GWPGLFLESA
RWLIVKRQIE EAQSVLRILA ERNRPHGQML GEEAQEALQE LENTCPLPTT STFSFASLLN
YRNIWKNLLI LGFTNFIAHA IRHCYQPVGG GGSPSDFYLC SLLASGTAAL ACVFLGVTVD
RFGRRGILLL SMTLTGIASL VLLGLWDYLN DAAITTFSVL GLFSSQASAI LSTLLAAEVI
PTTVRGRGLG LIMALGALGG LSCPAQRLHM GHGAFLQHVV LAACALLCIL SIMLLPETKR
KLLPEVLRDG ELCRRPSLLR QPPPNRCDHV PLLATPNPAL
