S22AI_RAT
ID S22AI_RAT Reviewed; 404 AA.
AC Q6AY78;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Solute carrier family 22 member 18;
DE AltName: Full=Organic cation transporter-like protein 2;
DE Short=ORCTL-2;
GN Name=Slc22a18; Synonyms=Orctl2, Tssc5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a transporter of organic cations based on a proton
CC efflux antiport mechanism. May play a role in the transport of
CC chloroquine and quinidine-related compounds in kidney (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Localized at the apical membrane
CC surface of renal proximal tubules. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH79159.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC079159; AAH79159.1; ALT_INIT; mRNA.
DR RefSeq; NP_001004260.1; NM_001004260.1.
DR RefSeq; XP_006230837.1; XM_006230775.3.
DR AlphaFoldDB; Q6AY78; -.
DR SMR; Q6AY78; -.
DR STRING; 10116.ENSRNOP00000027925; -.
DR PaxDb; Q6AY78; -.
DR PeptideAtlas; Q6AY78; -.
DR GeneID; 309131; -.
DR KEGG; rno:309131; -.
DR UCSC; RGD:1303323; rat.
DR CTD; 5002; -.
DR RGD; 1303323; Slc22a18.
DR eggNOG; ENOG502QT94; Eukaryota.
DR InParanoid; Q6AY78; -.
DR OrthoDB; 1090653at2759; -.
DR PhylomeDB; Q6AY78; -.
DR TreeFam; TF352510; -.
DR Reactome; R-RNO-549127; Organic cation transport.
DR PRO; PR:Q6AY78; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; ISO:RGD.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; ISO:RGD.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:RGD.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; ISO:RGD.
DR GO; GO:0042908; P:xenobiotic transport; ISO:RGD.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..404
FT /note="Solute carrier family 22 member 18"
FT /id="PRO_0000220511"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 404 AA; 43030 MW; F994057FC9009F1D CRC64;
MVALPRQGII ILTYVLAALE LTCLFMQFSI IPYLSRTLGL DSVSFGYLQT TFGVLQLLGG
PVFGRFADQR GARAALTLSF LAASALYLLL VASCSPALPG VFLLFASRLP AALMHTLPAA
QMVITDLTAP TKRPTALSRL GLCFGIGVIF GSLLGGTLST AYGIQCPAFL AFVVTLLGAV
LSFTCIPVTT KEASVQSAHQ GGTSVFDLKA ISRLLLLPRV LPVFLVKVIS GFPSGLFMVM
FSIISMDFFQ LEAAQAGYLM SFFGILQMMI QGLVIGRLST RFPEEALLRS SVLVFAVVGL
GMALMSNVFH FCLLLPGLVF SLCALNIVTD SMLTKAVSAS DTGTMLGLCA SVHPLTRTVG
PTLGGLLYRS YGVSILGHVQ LMVNLLVLLV LWKKPLSQKG DKAR
