S22AN_HUMAN
ID S22AN_HUMAN Reviewed; 686 AA.
AC A1A5C7; A1A5C8; Q5T8B8; Q6ZMH3; Q8IW73;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Solute carrier family 22 member 23;
GN Name=SLC22A23; Synonyms=C6orf85;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 21-686 (ISOFORM 4).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-686.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=17714910; DOI=10.1016/j.ygeno.2007.03.017;
RA Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.;
RT "Identification of six putative human transporters with structural
RT similarity to the drug transporter SLC22 family.";
RL Genomics 90:595-609(2007).
CC -!- INTERACTION:
CC A1A5C7; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10171756, EBI-10171774;
CC A1A5C7; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-10171756, EBI-3958099;
CC A1A5C7; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-10171756, EBI-945833;
CC A1A5C7-2; Q08AM2: ADAM33; NbExp=3; IntAct=EBI-12081840, EBI-10225815;
CC A1A5C7-2; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-12081840, EBI-10827839;
CC A1A5C7-2; P27352: CBLIF; NbExp=3; IntAct=EBI-12081840, EBI-3953638;
CC A1A5C7-2; Q9NWW5: CLN6; NbExp=3; IntAct=EBI-12081840, EBI-6165897;
CC A1A5C7-2; O95406: CNIH1; NbExp=3; IntAct=EBI-12081840, EBI-12172273;
CC A1A5C7-2; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-12081840, EBI-10976398;
CC A1A5C7-2; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-12081840, EBI-11749135;
CC A1A5C7-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12081840, EBI-16439278;
CC A1A5C7-2; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-12081840, EBI-2804156;
CC A1A5C7-2; P53801: PTTG1IP; NbExp=3; IntAct=EBI-12081840, EBI-3906138;
CC A1A5C7-2; O00526: UPK2; NbExp=3; IntAct=EBI-12081840, EBI-10179682;
CC A1A5C7-2; Q14508: WFDC2; NbExp=3; IntAct=EBI-12081840, EBI-723529;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A1A5C7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1A5C7-2; Sequence=VSP_028954;
CC Name=3;
CC IsoId=A1A5C7-3; Sequence=VSP_028955;
CC Name=4;
CC IsoId=A1A5C7-4; Sequence=VSP_028956;
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD18753.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL160398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040876; AAH40876.1; -; mRNA.
DR EMBL; BC128580; AAI28581.1; -; mRNA.
DR EMBL; BC128581; AAI28582.1; -; mRNA.
DR EMBL; AK172770; BAD18753.1; ALT_INIT; mRNA.
DR CCDS; CCDS34331.1; -. [A1A5C7-2]
DR CCDS; CCDS47363.1; -. [A1A5C7-1]
DR CCDS; CCDS75389.1; -. [A1A5C7-4]
DR RefSeq; NP_001273384.1; NM_001286455.1. [A1A5C7-2]
DR RefSeq; NP_001273385.1; NM_001286456.1. [A1A5C7-4]
DR RefSeq; NP_056297.1; NM_015482.1. [A1A5C7-1]
DR RefSeq; NP_068764.3; NM_021945.6. [A1A5C7-2]
DR RefSeq; XP_016866670.1; XM_017011181.1. [A1A5C7-2]
DR RefSeq; XP_016866675.1; XM_017011186.1. [A1A5C7-2]
DR AlphaFoldDB; A1A5C7; -.
DR SMR; A1A5C7; -.
DR BioGRID; 121960; 36.
DR IntAct; A1A5C7; 25.
DR STRING; 9606.ENSP00000385028; -.
DR TCDB; 2.A.1.19.28; the major facilitator superfamily (mfs).
DR GlyGen; A1A5C7; 2 sites.
DR iPTMnet; A1A5C7; -.
DR PhosphoSitePlus; A1A5C7; -.
DR BioMuta; SLC22A23; -.
DR MassIVE; A1A5C7; -.
DR PaxDb; A1A5C7; -.
DR PeptideAtlas; A1A5C7; -.
DR PRIDE; A1A5C7; -.
DR ProteomicsDB; 113; -. [A1A5C7-1]
DR ProteomicsDB; 114; -. [A1A5C7-2]
DR ProteomicsDB; 115; -. [A1A5C7-3]
DR ProteomicsDB; 116; -. [A1A5C7-4]
DR Antibodypedia; 9497; 69 antibodies from 20 providers.
DR DNASU; 63027; -.
DR Ensembl; ENST00000380298.2; ENSP00000369653.2; ENSG00000137266.15. [A1A5C7-4]
DR Ensembl; ENST00000380302.8; ENSP00000369657.4; ENSG00000137266.15. [A1A5C7-2]
DR Ensembl; ENST00000406686.8; ENSP00000385028.3; ENSG00000137266.15. [A1A5C7-1]
DR Ensembl; ENST00000490273.5; ENSP00000419463.1; ENSG00000137266.15. [A1A5C7-2]
DR GeneID; 63027; -.
DR KEGG; hsa:63027; -.
DR MANE-Select; ENST00000406686.8; ENSP00000385028.3; NM_015482.2; NP_056297.1.
DR UCSC; uc003mvm.5; human. [A1A5C7-1]
DR CTD; 63027; -.
DR DisGeNET; 63027; -.
DR GeneCards; SLC22A23; -.
DR HGNC; HGNC:21106; SLC22A23.
DR HPA; ENSG00000137266; Tissue enhanced (brain).
DR MIM; 611697; gene.
DR neXtProt; NX_A1A5C7; -.
DR OpenTargets; ENSG00000137266; -.
DR PharmGKB; PA162403516; -.
DR VEuPathDB; HostDB:ENSG00000137266; -.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000157354; -.
DR HOGENOM; CLU_001265_33_6_1; -.
DR InParanoid; A1A5C7; -.
DR OMA; NCISPES; -.
DR OrthoDB; 292012at2759; -.
DR PhylomeDB; A1A5C7; -.
DR TreeFam; TF335753; -.
DR PathwayCommons; A1A5C7; -.
DR SignaLink; A1A5C7; -.
DR BioGRID-ORCS; 63027; 9 hits in 1077 CRISPR screens.
DR ChiTaRS; SLC22A23; human.
DR GenomeRNAi; 63027; -.
DR Pharos; A1A5C7; Tbio.
DR PRO; PR:A1A5C7; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; A1A5C7; protein.
DR Bgee; ENSG00000137266; Expressed in pancreatic ductal cell and 173 other tissues.
DR ExpressionAtlas; A1A5C7; baseline and differential.
DR Genevisible; A1A5C7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..686
FT /note="Solute carrier family 22 member 23"
FT /id="PRO_0000308315"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..514
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 538..558
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 569..589
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 598..618
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 279
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..370
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028955"
FT VAR_SEQ 1..281
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028954"
FT VAR_SEQ 362..686
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028956"
FT CONFLICT 685
FT /note="A -> G (in Ref. 3; BAD18753)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 686 AA; 73748 MW; 035E53BA5FEDF8F0 CRC64;
MAIDRRREAA GGGPGRQPAP AEENGSLPPG DAAASAPLGG RAGPGGGAEI QPLPPLHPGG
GPHPSCCSAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV LLTWIPALFI GFSQFSDSFL
LDQPNFWCRG AGKGTELAGV TTTGRGGDMG NWTSLPTTPF ATAPWEAAGN RSNSSGADGG
DTPPLPSPPD KGDNASNCDC RAWDYGIRAG LVQNVVSKWD LVCDNAWKVH IAKFSLLVGL
IFGYLITGCI ADWVGRRPVL LFSIIFILIF GLTVALSVNV TMFSTLRFFE GFCLAGIILT
LYALRIELCP PGKRFMITMV ASFVAMAGQF LMPGLAALCR DWQVLQALII CPFLLMLLYW
SIFPESLRWL MATQQFESAK RLILHFTQKN RMNPEGDIKG VIPELEKELS RRPKKVCIVK
VVGTRNLWKN IVVLCVNSLT GYGIHHCFAR SMMGHEVKVP LLENFYADYY TTASIALVSC
LAMCVVVRFL GRRGGLLLFM ILTALASLLQ LGLLNLIGKY SQHPDSGMSD SVKDKFSIAF
SIVGMFASHA VGSLSVFFCA EITPTVIRCG GLGLVLASAG FGMLTAPIIE LHNQKGYFLH
HIIFACCTLI CIICILLLPE SRDQNLPENI SNGEHYTRQP LLPHKKGEQP LLLTNAELKD
YSGLHDAAAA GDTLPEGATA NGMKAM
