S22AN_MOUSE
ID S22AN_MOUSE Reviewed; 689 AA.
AC Q3UHH2; Q7TPT5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Solute carrier family 22 member 23;
GN Name=Slc22a23;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C3H/He; TISSUE=Osteoblast;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=17714910; DOI=10.1016/j.ygeno.2007.03.017;
RA Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.;
RT "Identification of six putative human transporters with structural
RT similarity to the drug transporter SLC22 family.";
RL Genomics 90:595-609(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UHH2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UHH2-2; Sequence=VSP_028957, VSP_028958;
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR EMBL; AK147397; BAE27885.1; -; mRNA.
DR EMBL; BC053705; AAH53705.1; -; mRNA.
DR CCDS; CCDS26446.1; -. [Q3UHH2-1]
DR RefSeq; NP_001028339.1; NM_001033167.3. [Q3UHH2-1]
DR AlphaFoldDB; Q3UHH2; -.
DR SMR; Q3UHH2; -.
DR STRING; 10090.ENSMUSP00000042742; -.
DR GlyGen; Q3UHH2; 2 sites.
DR iPTMnet; Q3UHH2; -.
DR PhosphoSitePlus; Q3UHH2; -.
DR MaxQB; Q3UHH2; -.
DR PaxDb; Q3UHH2; -.
DR PeptideAtlas; Q3UHH2; -.
DR PRIDE; Q3UHH2; -.
DR ProteomicsDB; 253363; -. [Q3UHH2-1]
DR ProteomicsDB; 253364; -. [Q3UHH2-2]
DR Antibodypedia; 9497; 69 antibodies from 20 providers.
DR Ensembl; ENSMUST00000040336; ENSMUSP00000042742; ENSMUSG00000038267. [Q3UHH2-1]
DR GeneID; 73102; -.
DR KEGG; mmu:73102; -.
DR UCSC; uc007qbg.1; mouse. [Q3UHH2-2]
DR UCSC; uc007qbh.1; mouse. [Q3UHH2-1]
DR CTD; 63027; -.
DR MGI; MGI:1920352; Slc22a23.
DR VEuPathDB; HostDB:ENSMUSG00000038267; -.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000157354; -.
DR InParanoid; Q3UHH2; -.
DR OMA; NCISPES; -.
DR OrthoDB; 292012at2759; -.
DR PhylomeDB; Q3UHH2; -.
DR TreeFam; TF335753; -.
DR BioGRID-ORCS; 73102; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Slc22a23; mouse.
DR PRO; PR:Q3UHH2; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3UHH2; protein.
DR Bgee; ENSMUSG00000038267; Expressed in pyloric antrum and 236 other tissues.
DR ExpressionAtlas; Q3UHH2; baseline and differential.
DR Genevisible; Q3UHH2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..689
FT /note="Solute carrier family 22 member 23"
FT /id="PRO_0000308316"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..509
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..276
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028957"
FT VAR_SEQ 522..529
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028958"
FT CONFLICT 370
FT /note="Q -> R (in Ref. 2; AAH53705)"
FT /evidence="ECO:0000305"
FT CONFLICT 501
FT /note="A -> V (in Ref. 2; AAH53705)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 689 AA; 74325 MW; 928C97B6BF58F02D CRC64;
MAIDRRREAA GSGAGRQPAP AEENGSLPPG DAAASAPLGG RAGSGSSAEI QPLPALHPSG
GPHSSCCAAT AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV VLTWIPALFI GFSQFSDSFL
LDQPDFWCRG AGKGTELAGA TVTGRWGDMG NWTSPSATPF STASWGTTSN RSNSSDTPPL
PSPPGKGNND SNCDCHAWDY GIRTGLIQNV VSKWDLVCDN TWKVHIAKFS LLVGLIFGYL
ITGCIADWVG RRPVLLFSTI FILIFGLTVA LSVNVTMFST LRFFEGFCLA GIILTLYALR
IELCPPGKRF IITMVASFVA MAGQFLMPGL AALCRDWQVL QALIICPFLL MLLYWSIFPE
SLRWLMATQQ FESAKKLILY LTQKNCVSPE SDIKGVMPEL EKELSRRPKK VCIVKVVGTR
NLWKNIVVLC VNSLTGYGIH HCFARSMMGH EVKVPLLENF YADYYTMASI ALASCLAMCL
VVKFLGRRGG LLLFMILTAL ASLLQLGLLN LIGKYSQHPD SELQLKLAVG MSDSVKDKFS
IAFSIVGMFA SHAVGSLSVF FCAEITPTVI RCGGLGLVLA SAGFGMLTAP IIELHNQKGY
FLHHIIFACC TLICIICILL LPESRNQNLP ENIANGEHYT RQPLLPHKKG EQPLLLTNAE
LKDYSGLHDV AAVGDGLPEG ATANGMKTM
