S22AN_RAT
ID S22AN_RAT Reviewed; 689 AA.
AC Q9QZG1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Solute carrier family 22 member 23;
DE AltName: Full=Ion transporter protein;
GN Name=Slc22a23; Synonyms=Nritp;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 327-689.
RC STRAIN=Sprague-Dawley; TISSUE=Cochlea;
RX PubMed=10719212; DOI=10.1016/s0169-328x(99)00328-9;
RA Stoever T., Gong T.-W.L., Cho Y., Altschuler R.A., Lomax M.I.;
RT "Expression of the GDNF family members and their receptors in the mature
RT rat cochlea.";
RL Brain Res. Mol. Brain Res. 76:25-35(2000).
RN [3]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=17714910; DOI=10.1016/j.ygeno.2007.03.017;
RA Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.;
RT "Identification of six putative human transporters with structural
RT similarity to the drug transporter SLC22 family.";
RL Genomics 90:595-609(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in many tissues, including brain, spinal
CC cord, kidney, liver, eye, adipose tissue, lung, epididymis, adrenal
CC gland, pineal gland, skeletal muscle, heart, spleen, thymus, ovary,
CC uterus, testis and epididymis. {ECO:0000269|PubMed:17714910}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AABR03104826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03104847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03105090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03105777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03106468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF184921; AAF01243.1; -; mRNA.
DR RefSeq; NP_072146.1; NM_022624.1.
DR AlphaFoldDB; Q9QZG1; -.
DR SMR; Q9QZG1; -.
DR BioGRID; 249140; 1.
DR STRING; 10116.ENSRNOP00000023149; -.
DR GlyGen; Q9QZG1; 2 sites.
DR PaxDb; Q9QZG1; -.
DR Ensembl; ENSRNOT00000023149; ENSRNOP00000023149; ENSRNOG00000017210.
DR GeneID; 64559; -.
DR KEGG; rno:64559; -.
DR UCSC; RGD:620302; rat.
DR CTD; 63027; -.
DR RGD; 620302; Slc22a23.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000157354; -.
DR HOGENOM; CLU_001265_33_6_1; -.
DR InParanoid; Q9QZG1; -.
DR OMA; NCISPES; -.
DR OrthoDB; 292012at2759; -.
DR PhylomeDB; Q9QZG1; -.
DR TreeFam; TF335753; -.
DR PRO; PR:Q9QZG1; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000017210; Expressed in liver and 18 other tissues.
DR Genevisible; Q9QZG1; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..689
FT /note="Solute carrier family 22 member 23"
FT /id="PRO_0000308317"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..509
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 327..328
FT /note="MP -> AT (in Ref. 2; AAF01243)"
FT /evidence="ECO:0000305"
FT CONFLICT 388
FT /note="S -> G (in Ref. 2; AAF01243)"
FT /evidence="ECO:0000305"
FT CONFLICT 522..529
FT /note="Missing (in Ref. 2; AAF01243)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 689 AA; 74208 MW; 870316640E94B856 CRC64;
MAIDRRREAA GSGAGRQPAP AEENGSLPPG DAAASAPLGG RAGSGGSAEI QPLPALHPSG
GPHSSCCAAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV VLTWIPALFI GFSQFSDSFL
LDQPNFWCHG AGKGTELAGA TVTGRWGDMG NWTSPSATPF STASWGTTSN RSNSSDTPPL
PSPPGKGNND SNCECHAWDY GIRTGLVQNV VSKWDLVCDN AWKVHVAKFS LLVGLIFGYL
ITGCIADWVG RRPVLLFSVI FILIFGLTVA LSVNVTMFST LRFFEGFCLA GIILTLYALR
IELCPPGKRF IITMVASFVA MAGQFLMPGL AALCRDWQVL QALIICPFLL MLLYWSIFPE
SLRWLMATQQ FESAKKLILY LTQKNCVSPE SDIKGVMPEL EKELSRRPKK VCIVKVVGTR
NLWKNIVVLC VNSLTGYGIH HCFARSMMGH EVKVPLLENF YADYYTMASI ALASCLAMCL
VVRFLGRRGG LLLFMILTAL ASLLQLGLLN LIGKYSQHPD SELQLKLAVG MSDSVKDKFS
IAFSIVGMFA SHAVGSLSVF FCAEITPTVI RCGGLGLVLA SAGFGMLTAP IIELHNQKGY
FLHHIIFACC TLICIICILL LPESRDQNLP ENIANGEHYT RQPLLSHKKG EQPLLLTNAE
LKDYSGLHDV AAVGDGLSEG ATANGMKTM
