ID   S22AO_PONAB             Reviewed;         330 AA.
AC   Q5RC45;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Steroid transmembrane transporter SLC22A24 {ECO:0000305};
DE   AltName: Full=Solute carrier family 22 member 24;
GN   Name=SLC22A24;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Steroid transmembrane transporter that functions in the
CC       reabsorption of conjugated steroids in the kidney and is involved in
CC       steroid homeostasis. {ECO:0000250|UniProtKB:Q8N4F4}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC       Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR   EMBL; CR858436; CAH90665.1; -; mRNA.
DR   RefSeq; NP_001125361.1; NM_001131889.2.
DR   AlphaFoldDB; Q5RC45; -.
DR   SMR; Q5RC45; -.
DR   STRING; 9601.ENSPPYP00000003622; -.
DR   PRIDE; Q5RC45; -.
DR   GeneID; 100172263; -.
DR   KEGG; pon:100172263; -.
DR   CTD; 283238; -.
DR   eggNOG; KOG0255; Eukaryota.
DR   InParanoid; Q5RC45; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0008202; P:steroid metabolic process; ISS:UniProtKB.
DR   GO; GO:0035382; P:sterol transmembrane transport; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Lipid metabolism; Membrane; Reference proteome;
KW   Steroid metabolism; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..330
FT                   /note="Steroid transmembrane transporter SLC22A24"
FT                   /id="PRO_0000317527"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   330 AA;  37086 MW;  BAFA98BD3BBFBA4F CRC64;
     MGFDVLLDQV GGMGRFQICL IAFFCIANIL LFPNIVLENF TAFTPGHRCW VPLLDNDTVS
     DNDTGTLSKD DLLRISIPLD SNLRPQKCQR FIHPQWQLLH LKGTFPNTNE TDTEPCVDGW
     VYDRTSFLST IVTEWDLVCE SQSLKSMVQS LFMAGSLLGG LIYGHLSDRV GRKIICKLCF
     LQLAISNTCA AFAPTFLVYC ILRFLAGFST MTILGNTFIL SLEWTLPQSR SMAIMVLLCS
     YSVGQMLLGG LAFAIQDWRV LQLTVSTPII VLFLSSWKMV ESARWLIINN QLDEGLKELR
     RVAHTNGKKN TEETLTAEVI WKGEMIAVIK