S22AV_HUMAN
ID S22AV_HUMAN Reviewed; 556 AA.
AC A6NKX4; S4R3Q8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 4.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Putative solute carrier family 22 member 31 {ECO:0000305};
GN Name=SLC22A31 {ECO:0000312|HGNC:HGNC:27091};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- FUNCTION: Organic anion transporter that mediates the uptake of ions.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR EMBL; AC009113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A6NKX4; -.
DR SMR; A6NKX4; -.
DR STRING; 9606.ENSP00000481421; -.
DR TCDB; 2.A.1.19.23; the major facilitator superfamily (mfs).
DR iPTMnet; A6NKX4; -.
DR PhosphoSitePlus; A6NKX4; -.
DR BioMuta; SLC22A31; -.
DR MassIVE; A6NKX4; -.
DR PeptideAtlas; A6NKX4; -.
DR PRIDE; A6NKX4; -.
DR Ensembl; ENST00000562855.7; ENSP00000474621.2; ENSG00000259803.8.
DR GeneCards; SLC22A31; -.
DR HGNC; HGNC:27091; SLC22A31.
DR HPA; ENSG00000259803; Group enriched (brain, lung, pancreas).
DR neXtProt; NX_A6NKX4; -.
DR VEuPathDB; HostDB:ENSG00000259803; -.
DR eggNOG; KOG0255; Eukaryota.
DR InParanoid; A6NKX4; -.
DR PhylomeDB; A6NKX4; -.
DR Pharos; A6NKX4; Tdark.
DR PRO; PR:A6NKX4; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A6NKX4; protein.
DR Bgee; ENSG00000259803; Expressed in cerebellar hemisphere and 116 other tissues.
DR ExpressionAtlas; A6NKX4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..556
FT /note="Putative solute carrier family 22 member 31"
FT /id="PRO_0000333031"
FT TOPO_DOM 1..23
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..128
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..182
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..246
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 340..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 358..366
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 388..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 417..420
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 442..448
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 470..483
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 505..556
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 524..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 58815 MW; AAE24E82A711AD14 CRC64;
MEQEARVLRA AGGFGRARRL LASASWVPCI VLGLVLSSEE LLTAQPAPHC RPDPTLLPPA
LRALRGPALL DAAIPRLGPT RAPAEALGVL SPSYLAPLTR APRPSSWASC SGAAAGPTWN
LVCGDGWKVP LEQVSHLLGW LLGCVILGAG CDRFGRRAVF VASLVLTTGL GASEALAASF
PTLLVLRLLH GGTLAGALLA LYLARLELCD PPHRLAFSMG AGLFSVVGTL LLPGLAALVQ
DWRLLQGLGA LMSGLLLLFW GFPALFPESP CWLLATGQVA RARKILWRFA EASGVGPGDS
SLEENSLATE LTMLSARSPQ PRYHSPLGLL RTRVTWRNGL ILGFSSLVGG GIRASFRRSL
APQVPTFYLP YFLEAGLEAA ALVFLLLTAD CCGRRPVLLL GTMVTGLASL LLLAGAQYLP
GWTVLFLSVL GLLASRAVSA LSSLFAAEVF PTVIRGAGLG LVLGAGFLGQ AAGPLDTLHG
RQGFFLQQVV FASLAVLALL CVLLLPESRS RGLPQSLQDA DRLRRSPLLR GRPRQDHLPL
LPPSNSYWAG HTPEQH
