S22BB_DANRE
ID S22BB_DANRE Reviewed; 215 AA.
AC Q7SXP0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Vesicle-trafficking protein SEC22b-B;
DE AltName: Full=SEC22 vesicle-trafficking protein homolog B-B;
GN Name=sec22bb {ECO:0000312|EMBL:AAH55515.1};
GN Synonyms=sec22l1b {ECO:0000312|ZFIN:ZDB-GENE-030131-5488};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:AAH55515.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: SNARE involved in targeting and fusion of ER-derived
CC transport vesicles with the Golgi complex as well as Golgi-derived
CC retrograde transport vesicles with the ER.
CC {ECO:0000250|UniProtKB:O75396, ECO:0000250|UniProtKB:Q4KM74}.
CC -!- SUBUNIT: Component of 2 distinct SNARE complexes.
CC {ECO:0000250|UniProtKB:O75396}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q4KM74}; Single-pass type IV membrane protein
CC {ECO:0000250|UniProtKB:Q4KM74}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000250|UniProtKB:Q4KM74}. Golgi
CC apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q4KM74}.
CC Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250|UniProtKB:Q4KM74}. Melanosome
CC {ECO:0000250|UniProtKB:O75396}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000255}.
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DR EMBL; BC055515; AAH55515.1; -; mRNA.
DR RefSeq; NP_958459.1; NM_201302.2.
DR AlphaFoldDB; Q7SXP0; -.
DR SMR; Q7SXP0; -.
DR STRING; 7955.ENSDARP00000114891; -.
DR PaxDb; Q7SXP0; -.
DR Ensembl; ENSDART00000159044; ENSDARP00000136767; ENSDARG00000100435.
DR GeneID; 327277; -.
DR KEGG; dre:327277; -.
DR CTD; 327277; -.
DR ZFIN; ZDB-GENE-030131-5488; sec22bb.
DR eggNOG; KOG0862; Eukaryota.
DR GeneTree; ENSGT00940000156349; -.
DR HOGENOM; CLU_054453_4_1_1; -.
DR InParanoid; Q7SXP0; -.
DR PhylomeDB; Q7SXP0; -.
DR Reactome; R-DRE-1236974; ER-Phagosome pathway.
DR Reactome; R-DRE-204005; COPII-mediated vesicle transport.
DR Reactome; R-DRE-5694530; Cargo concentration in the ER.
DR Reactome; R-DRE-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:Q7SXP0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000100435; Expressed in brain and 27 other tissues.
DR ExpressionAtlas; Q7SXP0; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR044565; Sec22.
DR InterPro; IPR042855; V_SNARE_CC.
DR PANTHER; PTHR45837; PTHR45837; 1.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..215
FT /note="Vesicle-trafficking protein SEC22b-B"
FT /id="PRO_0000252244"
FT TOPO_DOM 1..190
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..215
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT DOMAIN 6..119
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT DOMAIN 134..194
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ SEQUENCE 215 AA; 24689 MW; 3C40B9DE9B87A8A5 CRC64;
MVLLTMIARL ADGLPLAASM QEDEQMGRDL QQYQSQAKQL FRKLNEQSPN RCTLEAGSMS
FHYVIEKGVC YLVLCEAGFP KKLAFAYLED LQAEFHEQHG KKVPTVSRPY SFIEFDTYIQ
KTKKSYIDSR ARRNLSNINT ELQDVQRIMV ANIEEVLQRG EALSALDSKA SNLSSLSKKY
RSDAKYLNTR STYAKLAAGG VFFIMLIVYI RFWWL
