ID   S22FL_XENLA             Reviewed;         487 AA.
AC   Q7ZX53;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Solute carrier family 22 member 15-like;
GN   Name=slc22a15b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably transports organic cations. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC       Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR   EMBL; BC045234; AAH45234.1; -; mRNA.
DR   RefSeq; NP_001079621.1; NM_001086152.1.
DR   AlphaFoldDB; Q7ZX53; -.
DR   SMR; Q7ZX53; -.
DR   DNASU; 379308; -.
DR   GeneID; 379308; -.
DR   KEGG; xla:379308; -.
DR   CTD; 379308; -.
DR   Xenbase; XB-GENE-5824727; slc22a15.2.S.
DR   OrthoDB; 464838at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 379308; Expressed in liver and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..487
FT                   /note="Solute carrier family 22 member 15-like"
FT                   /id="PRO_0000338623"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   487 AA;  53844 MW;  19B524C5F8A560BE CRC64;
     MDLDEAFLYV GEFGWCQKRL TGFLTLLQIY VACQSMLIVL VGAVPEYLID NEDISTSKED
     YIKHLHDANN FTSIVSEWHL IKHEAYKVNL ASSLFFAGLL IGNVFFGPLS DKLGRRPVYL
     SGLFFDIIFG YFTALAPSYE VFAVSRFFVG VMNGGMALVS FVLTQEYVGK SYWALTGSLT
     NLIFAVGIAF YALLGFYIRN WRTLAFVANS PGIFFLLLSF VLPESPRWLY SRGYTAEAEA
     VLESMAAGNG VERPVVRLKS CPGTTANSAH SVFDLVKYGV LRWRTILLMY IWYVCSLVYY
     GLTLNAGELK GNLYLNVALY GLVEVPAFPL CLYFIEKSWS GRRRATAGFL VFAGFACIFT
     IFVPETNGDF INPTVLALFG KLSVSAAFNV VYIYTSELYP TVVRNAGLGV CAMACRFGGI
     LSPFIPAMKS FNPSMPFVAF GISGISAGIL SLLLPETRNK PIAETIEDLQ SPAYQLLSRG
     NEVLAST