ID   S22FL_XENTR             Reviewed;         487 AA.
AC   Q28ES4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Solute carrier family 22 member 15-like;
GN   Name=slc22a15b; ORFNames=TGas054i12.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably transports organic cations. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC       Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
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DR   EMBL; CR848093; CAJ81539.1; -; mRNA.
DR   RefSeq; NP_001039179.1; NM_001045714.1.
DR   AlphaFoldDB; Q28ES4; -.
DR   SMR; Q28ES4; -.
DR   STRING; 8364.ENSXETP00000045314; -.
DR   PaxDb; Q28ES4; -.
DR   GeneID; 734018; -.
DR   KEGG; xtr:734018; -.
DR   CTD; 734018; -.
DR   Xenbase; XB-GENE-5824718; slc22a15.2.
DR   eggNOG; KOG0255; Eukaryota.
DR   InParanoid; Q28ES4; -.
DR   OrthoDB; 464838at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020972; Expressed in heart and 14 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..487
FT                   /note="Solute carrier family 22 member 15-like"
FT                   /id="PRO_0000338624"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   487 AA;  53644 MW;  A02C8BF66194441F CRC64;
     MDLDEAFLYI GEFGCCQKRL TAFLTLLQVY VACQSMLIVL VGAVPEYLID NEDISASKEE
     YTKHLHDTNN FTSIVSEWHL IKNEAYKVNL ASSLFFAGLL IGNILFGPLS DKLGRRPVYL
     SGLFFDITFG YCTALAPSYE VFAVSRFFVG IMNGGMALVS FVLTQEYVGK SYWALTGSLT
     NLIFAVGIAF YALLGFYIRN WRTLAFVANS PGIFFFLLSF LLPESPRWLY SHGYTTEAEG
     VLQSMAVGNG VERPVVKLKS CPGTSSKSAH SVFDLVKYGV LRWRTILLMY IWYVCSLVYY
     GLTLNAGELK GNLYLNVALY GLVEVPAFPL CLYFIEKSWS GRRKATAGFL GFAGFACIFT
     IFLPETNGDL LNPTVLALFG KLSVSAAFNV VYIYTSELYP TVVRNAGLGV CAMACRFGGI
     LSPFIPTMKS LNPSMPFVAF GISGISAGIL SLLLPETRNK PIAESIEDLQ SPAYQLLSRG
     NEVLAST