S23A2_XENTR
ID S23A2_XENTR Reviewed; 649 AA.
AC B0JZG0;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Solute carrier family 23 member 2 {ECO:0000250|UniProtKB:Q9UGH3};
DE AltName: Full=Na(+)/L-ascorbic acid transporter 2 {ECO:0000250|UniProtKB:Q9UGH3};
DE AltName: Full=Sodium-dependent vitamin C transporter 2 {ECO:0000250|UniProtKB:Q9UGH3};
GN Name=slc23a2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAI59164.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis {ECO:0000312|EMBL:AAI59164.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium/ascorbate cotransporter. Mediates electrogenic uptake
CC of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
CC {ECO:0000250|UniProtKB:Q9UGH3}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ascorbate(out) + 2 Na(+)(out) = L-ascorbate(in) + 2
CC Na(+)(in); Xref=Rhea:RHEA:69883, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:38290; Evidence={ECO:0000250|UniProtKB:Q9UGH3};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UGH3};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UGH3}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000305}.
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DR EMBL; BC159163; AAI59164.1; -; mRNA.
DR RefSeq; NP_001120161.1; NM_001126689.1.
DR RefSeq; XP_012821509.1; XM_012966055.2.
DR RefSeq; XP_012821510.1; XM_012966056.2.
DR RefSeq; XP_012821511.1; XM_012966057.2.
DR AlphaFoldDB; B0JZG0; -.
DR SMR; B0JZG0; -.
DR PaxDb; B0JZG0; -.
DR Ensembl; ENSXETT00000099885; ENSXETP00000089059; ENSXETG00000039709.
DR GeneID; 100145200; -.
DR KEGG; xtr:100145200; -.
DR CTD; 9962; -.
DR Xenbase; XB-GENE-966414; slc23a2.
DR eggNOG; KOG1292; Eukaryota.
DR HOGENOM; CLU_017959_5_4_1; -.
DR InParanoid; B0JZG0; -.
DR OrthoDB; 387031at2759; -.
DR PhylomeDB; B0JZG0; -.
DR Reactome; R-XTR-196836; Vitamin C (ascorbate) metabolism.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000039709; Expressed in neurula embryo and 20 other tissues.
DR ExpressionAtlas; B0JZG0; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0008520; F:L-ascorbate:sodium symporter activity; IEA:InterPro.
DR GO; GO:0015229; F:L-ascorbic acid transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0019852; P:L-ascorbic acid metabolic process; IBA:GO_Central.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR029956; SlC23A2.
DR InterPro; IPR006042; Xan_ur_permease.
DR PANTHER; PTHR11119:SF33; PTHR11119:SF33; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..649
FT /note="Solute carrier family 23 member 2"
FT /id="PRO_0000385450"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 649 AA; 70559 MW; 390120330303E86B CRC64;
MGIGRNPSSK AMESTNSTDG KYEEESKHTA FFTLPAVING GAASSGDQDT EDTELMAIYT
TESGIAEKSS LAETLDSTGS LDRQRLDMIY TVEDVPPWYL CIFLGLQHYL TCFSGTVAVP
FLLAEAMCVG FDQWATSQLI GTIFFCVGIT TLFQTTFGCR LPLFQASAFA FLAPARAILS
LEKWKCNTTD LSITNGTELL HTEHIWYPRI REIQGAIIMS SLIEVVIGFL GLPGALLKYI
GPLTITPTVS LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKL PLPIYKSKKG
WTAYKLQLFK MFPIIMAILV SWLLCFIFTV TDVFPPDSSK YGYYARTDAR QGVLTVAPWF
KVPYPFQWGL PTVSAAGVIG MLSAVVASII ESIGDYYACA RLSCAPPPPI HAINRGIFIE
GLSCVLDGVF GTGNGSTSSS PNIGVLGITK VASRRVIQYG AAFMLLLGMI GKFSALFASL
PDPVLGALFC TLFGMITAVG LSNLQFVDLN SSRNLFVLGF SIFFGLMLPS YLKQNPLVTG
IAEIDQVLNV LLTTAMFVGG CTAFILDNTI PGTPEERGIR KWKRGVGKGT SGIEGMESYD
LPFGMGFLRR YKCFSYLPIS PTFAGYQWKA LRKCGSCPRA AEEEPEPAV
