S23A3_MOUSE
ID S23A3_MOUSE Reviewed; 611 AA.
AC Q60850; Q149H3; Q4VBX5; Q60851; Q60852; Q60853; Q78E82; Q78E83; Q78E84;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Solute carrier family 23 member 3;
DE AltName: Full=Na(+)/L-ascorbic acid transporter 3;
DE AltName: Full=Sodium-dependent vitamin C transporter 3;
DE AltName: Full=Yolk sac permease-like molecule 1;
DE Short=YSPL-1;
GN Name=Slc23a3; Synonyms=Svct3, Yspl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), AND SUBCELLULAR
RP LOCATION.
RC STRAIN=BALB/cJ; TISSUE=Yolk sac;
RX PubMed=7588067; DOI=10.1242/dev.121.10.3335;
RA Guimaraes M.J., Bazan J.F., Zlotnik A., Wiles M.V., Grimaldi J.C., Lee F.,
RA McClanahan T.;
RT "A new approach to the study of haematopoietic development in the yolk sac
RT and embryoid bodies.";
RL Development 121:3335-3346(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=YSPL-1 form 1;
CC IsoId=Q60850-1; Sequence=Displayed;
CC Name=2; Synonyms=YSPL-1 form 2;
CC IsoId=Q60850-2; Sequence=VSP_033975;
CC Name=3; Synonyms=YSPL-1 form 3;
CC IsoId=Q60850-3; Sequence=VSP_033976;
CC Name=4; Synonyms=YSPL-1 form 4;
CC IsoId=Q60850-4; Sequence=VSP_033977;
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH94893.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U25739; AAA92292.1; -; mRNA.
DR EMBL; U25739; AAA92293.1; -; mRNA.
DR EMBL; U25739; AAA92294.1; -; mRNA.
DR EMBL; U25739; AAA92295.1; -; mRNA.
DR EMBL; BC094893; AAH94893.1; ALT_FRAME; mRNA.
DR EMBL; BC117790; AAI17791.1; -; mRNA.
DR EMBL; BC117791; AAI17792.1; -; mRNA.
DR CCDS; CCDS15062.1; -. [Q60850-1]
DR RefSeq; NP_919314.2; NM_194333.3.
DR AlphaFoldDB; Q60850; -.
DR SMR; Q60850; -.
DR BioGRID; 204618; 1.
DR IntAct; Q60850; 1.
DR STRING; 10090.ENSMUSP00000027405; -.
DR iPTMnet; Q60850; -.
DR PhosphoSitePlus; Q60850; -.
DR PaxDb; Q60850; -.
DR PRIDE; Q60850; -.
DR ProteomicsDB; 253368; -. [Q60850-1]
DR ProteomicsDB; 253369; -. [Q60850-2]
DR ProteomicsDB; 253370; -. [Q60850-3]
DR ProteomicsDB; 253371; -. [Q60850-4]
DR DNASU; 22626; -.
DR GeneID; 22626; -.
DR KEGG; mmu:22626; -.
DR UCSC; uc007bno.1; mouse. [Q60850-1]
DR CTD; 151295; -.
DR MGI; MGI:104516; Slc23a3.
DR eggNOG; KOG1292; Eukaryota.
DR InParanoid; Q60850; -.
DR OrthoDB; 387031at2759; -.
DR PhylomeDB; Q60850; -.
DR TreeFam; TF313272; -.
DR BioGRID-ORCS; 22626; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Slc23a3; mouse.
DR PRO; PR:Q60850; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q60850; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015229; F:L-ascorbic acid transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR029957; SLC23A3.
DR PANTHER; PTHR11119:SF57; PTHR11119:SF57; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..611
FT /note="Solute carrier family 23 member 3"
FT /id="PRO_0000337204"
FT TOPO_DOM 1..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 341..358
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 380..397
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..426
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..455
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 476..489
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 511..611
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 574..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..537
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:7588067"
FT /id="VSP_033977"
FT VAR_SEQ 1..489
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:7588067"
FT /id="VSP_033976"
FT VAR_SEQ 1..106
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7588067"
FT /id="VSP_033975"
FT CONFLICT 43
FT /note="F -> C (in Ref. 2; AAH94893/AAI17791/AAI17792)"
FT /evidence="ECO:0000305"
FT CONFLICT 557
FT /note="K -> R (in Ref. 2; AAH94893/AAI17791/AAI17792)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 611 AA; 64878 MW; B0313601BC5E6527 CRC64;
MSRSPLHPIP LLSEGYQDTP APLPPLLPPL QNPSSRSWAS RVFGPSTWGL SCLLALQHFL
VLASLLWASH LLLLHGLPPG GLSYPPAQLL ASSFFSCGLS TVLQTWMGSR LPLIQAPSLE
FLIPALVLTN QKLPLTTKTP GNASLSLPLC SLTRSCHGLE LWNTSLREVS GAVVVSGLLQ
GTIGLLGVPG RVFPYCGPLV LAPSLVVAGL SAHKEVAQFC SAHWGLALLL ILLMVVCSQH
LGSCQIPLCS WRPSSTSTHI CIPVFRLLSV LAPVACVWFI SAFVGTSVIP LQLSEPSDAP
WFWLPHPGEW EWPLLTPRAL AAGISMALAA STSSLGCYAL CGQLLRLSPP PPHACSRGLS
LEGLGSVLAG LLGSPLGTAS SFPNVGTVSL FQTGSRRVAH LVGLFCMGLG LSPRLAQLFT
SIPLPVLGGV LGVTQAVVLS AGFSSFHLAD IDSGRNVFIV GFSIFMALLL PRWLREAPVL
LNTGWSPLDM FLRSLLAEPI FLAGLLGFLL ENTISGTRAE RGLGQRLPTS FTAQEIQMLQ
QSRRKAAQEY GLPLPIKNLC SCIPQPLHCL CPMPEDSGDE GGSSKTGERA DLLPNSGESY
STASREGVRS Q
