S23IP_MOUSE
ID S23IP_MOUSE Reviewed; 998 AA.
AC Q6NZC7; Q8BXY6;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 09-NOV-2004, sequence version 2.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=SEC23-interacting protein;
GN Name=Sec23ip;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-73 AND 833-998.
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-918.
RC STRAIN=C57BL/6NCr; TISSUE=Hematopoietic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-600; SER-735 AND SER-748, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in the organization of endoplasmic reticulum
CC exit sites. Specifically binds to phosphatidylinositol 3-phosphate
CC (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and
CC phosphatidylinositol 5-phosphate (PI(5)P). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SEC23A. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC Cytoplasmic side {ECO:0000250}. Endoplasmic reticulum {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PA-PLA1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH66195.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; BY726433; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK042851; BAC31382.1; -; mRNA.
DR EMBL; BC066195; AAH66195.1; ALT_SEQ; mRNA.
DR CCDS; CCDS21900.1; -.
DR AlphaFoldDB; Q6NZC7; -.
DR SMR; Q6NZC7; -.
DR IntAct; Q6NZC7; 2.
DR STRING; 10090.ENSMUSP00000035610; -.
DR iPTMnet; Q6NZC7; -.
DR PhosphoSitePlus; Q6NZC7; -.
DR EPD; Q6NZC7; -.
DR jPOST; Q6NZC7; -.
DR MaxQB; Q6NZC7; -.
DR PaxDb; Q6NZC7; -.
DR PeptideAtlas; Q6NZC7; -.
DR PRIDE; Q6NZC7; -.
DR ProteomicsDB; 260892; -.
DR MGI; MGI:2450915; Sec23ip.
DR eggNOG; KOG2308; Eukaryota.
DR InParanoid; Q6NZC7; -.
DR PhylomeDB; Q6NZC7; -.
DR Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR ChiTaRS; Sec23ip; mouse.
DR PRO; PR:Q6NZC7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6NZC7; protein.
DR GO; GO:0005801; C:cis-Golgi network; IDA:MGI.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IDA:MGI.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IDA:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004620; F:phospholipase activity; IBA:GO_Central.
DR GO; GO:0001675; P:acrosome assembly; IMP:MGI.
DR GO; GO:0007338; P:single fertilization; IMP:MGI.
DR GO; GO:0007286; P:spermatid development; IMP:MGI.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR004177; DDHD_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR Pfam; PF02862; DDHD; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM01127; DDHD; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS51043; DDHD; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Membrane; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..998
FT /note="SEC23-interacting protein"
FT /id="PRO_0000097555"
FT DOMAIN 640..703
FT /note="SAM"
FT DOMAIN 777..987
FT /note="DDHD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00378"
FT REGION 1..363
FT /note="Interaction with SEC23A"
FT /evidence="ECO:0000250"
FT REGION 50..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..232
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 600
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 735
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 748
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 924
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6Y8"
SQ SEQUENCE 998 AA; 110780 MW; C8C61ED1E74E0060 CRC64;
MADRKANGGG ASASSSGTNL LFSSSATEFS FNVPFIPVTQ AAASPASLLL PGEDSTDVGE
EDSFLGQTST HTSTPQTFSY FSQVSSSSDP FGNIGQSPLT TSAMSAGQSA LPKPPATLAF
TTGSQDALSA FPPSVSKAPG ATPPSQMGTS TYSPSQPSSL PPNFGSPPQG IPQQGHNPYR
HTPVSSRANP YITPPQLQQC QMPGHSSYPP PSGPPVQTYQ MPPGPLPPLP TAMQSPAQQQ
VPARPAGPLV QGPSPFVLQN QYEPVQPHWF YCKEVEYKQL WMPFSVLDSL NLEEIYNSVQ
PDPESVVLGT DGGRYDVYLY DRMRKSVYWE EEPTEVRRCT WFYKGDTDSR FIPYTEEFSE
KLEAEYKKAV STNQWHRRLE FPSGETIVMH NPKVIVQFQP SSVPDEWGTT QDGQTRPRVV
KRGIDDSLDE IPDGEMPQVD HLVFMVHGIG PVCDLRFRSI IECVDDFRVV SLKLLQTHFK
KSVDEGKVSR VEFLPVHWHS ALGGHATGVD RNIKKITLPS IGRFRHFTNE TLLDVLFYNS
PTYCQAIVEK VEVEINRLHS LFMSRNPNFK GKVSVAGHSL GSLILFDILS NQRDMCVSKS
PGSVAVSNGV IKHSQFQEKL ISEESKLMSD ESCDLDVEDE EPLTLHGTLE ALSLFDYIST
FEKEKIDMES LLMCTVDDLK EMGIPLGPRK KIANFVKLKA AKLEQKKAAA EKKAALAALT
KGQDESAPKT KEMASPSSES NESKRKLSVG AYVSSVRVDY ESFEVGTGQV SVAYSSLDFE
PEIFFALGSP IGMLLTIRGV ARIDEKYRLP TCKGFFNIYH PLDPVAYRLE PMIAPDLDLK
AVLVPHHKGR KRLHLELKES LSRMGSDLKQ GFISSLKSAW QTLNEFARAH TSTTQLQEEL
EKVANQIKEE EEKQVVEAKK KKESPELSKD EDYLGKVGML NGGRRIDYVL QEKPIESFNE
YLFALQSHLC YWGSEDTALL LLKEIYRTMN ISPEQPQH
