ID   S246A_XENLA             Reviewed;         417 AA.
AC   Q6INQ6;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Solute carrier family 25 member 46-A;
GN   Name=slc25a46-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in mitochondrial dynamics by controlling
CC       mitochondrial membrane fission. {ECO:0000250|UniProtKB:Q96AG3}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q96AG3}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC072218; AAH72218.1; -; mRNA.
DR   RefSeq; NP_001085164.1; NM_001091695.1.
DR   AlphaFoldDB; Q6INQ6; -.
DR   DNASU; 432247; -.
DR   GeneID; 432247; -.
DR   KEGG; xla:432247; -.
DR   CTD; 432247; -.
DR   Xenbase; XB-GENE-6255737; slc25a46.S.
DR   OrthoDB; 937901at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 432247; Expressed in ovary and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090149; P:mitochondrial membrane fission; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR039158; SLC25A46.
DR   PANTHER; PTHR21252; PTHR21252; 1.
DR   Pfam; PF00153; Mito_carr; 2.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..417
FT                   /note="Solute carrier family 25 member 46-A"
FT                   /id="PRO_0000291833"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          95..186
FT                   /note="Solcar 1"
FT   REPEAT          310..415
FT                   /note="Solcar 2"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   417 AA;  46150 MW;  1DA1DD846299F1C9 CRC64;
     MQPRRPDRFD GLEYRGTSWG RGEGDPPPYQ SSFPARSFSS SGDLSQHWVT TPPDIPGSRN
     LHWGDKSPQY GGADSNAGPP AFGEENSNSA NSGEQLNRFA GFGIGLASLF TENVLAHPCI
     VLRRQCQVNY HARNYQLSPF NIVNIMYNFT KTQGLRALWK GMGSTFIVQG ISLGAEGILS
     EFTHLPRELN HKWNPKQIGG HLLLKGLVYV IVTPFYSASL IETVQSEIIH DNPGILDCLK
     EGMGRVLNLG VPYSKRLLPL LVLTFPTVLH GILHYIVSST VQKCVLFFIK KKSPPRLPAD
     GSNTVQNKLE DYFPELIANF AASLCADVLL YPLETVLHRL HIQGTRTIID NTDLGHEVVP
     INTQYEGLKD CINTIKREEG GLGFYKGFGA VVVQYTLHAI VLQITKIIYS SVVQTSS