ID   S246B_XENLA             Reviewed;         414 AA.
AC   Q63ZR7;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Solute carrier family 25 member 46-B;
GN   Name=slc25a46-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in mitochondrial dynamics by controlling
CC       mitochondrial membrane fission. {ECO:0000250|UniProtKB:Q96AG3}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q96AG3}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC082843; AAH82843.1; -; mRNA.
DR   RefSeq; NP_001088052.1; NM_001094583.1.
DR   AlphaFoldDB; Q63ZR7; -.
DR   DNASU; 494746; -.
DR   GeneID; 494746; -.
DR   KEGG; xla:494746; -.
DR   CTD; 494746; -.
DR   Xenbase; XB-GENE-5804011; slc25a46.L.
DR   OrthoDB; 937901at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 494746; Expressed in oocyte and 5 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
DR   GO; GO:0090149; P:mitochondrial membrane fission; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR039158; SLC25A46.
DR   PANTHER; PTHR21252; PTHR21252; 1.
DR   Pfam; PF00153; Mito_carr; 2.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..414
FT                   /note="Solute carrier family 25 member 46-B"
FT                   /id="PRO_0000291834"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          92..183
FT                   /note="Solcar 1"
FT   REPEAT          307..412
FT                   /note="Solcar 2"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  45782 MW;  DF2B5907AEA81894 CRC64;
     MQPRRPDRFD GLEYRGTSWG RGDGDVPPYQ SSFPARSLSS SGDLSQQWVT SPPDIPGSRN
     LHWGEKSPQY GADSNAGPPA FGEENSGSSG EQVNRFAGFG IGLASLFTEN VLAHPCIVLR
     RQCQVNYHAQ NYQLSPFSIV NIMYNFTKTQ GPRALWKGMG STFIVQGISL GAEGMLSEFT
     HLPRELSHKW NLKQLGGHLL LKGLVYVIVT PFYSASLIET VQSEIIHDNP GILDCLKEGI
     GRVLNLGVPY SKRLLPLLVL TFPTVLHGIL HYIISSTIQK CVLFFIKKRS PPQLPAEGSN
     AVQNKLEDYF PELLANFAAS LCADVLLYPL ETVMHRLHIQ GTRTIIDNTD LGHEVVPINT
     QYEGLKDCIN TIKREEGGLG FYKGFGAVVV QYTLHAIVLQ ITKIIYSSVV QTAR