BEND4_HUMAN
ID BEND4_HUMAN Reviewed; 534 AA.
AC Q6ZU67; A1A5D6; A1A5D7; C9JQZ5; Q58A26; Q58A27;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 3.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=BEN domain-containing protein 4;
DE AltName: Full=Coiled-coil domain-containing protein 4;
GN Name=BEND4; Synonyms=CCDC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Prostatic carcinoma;
RA Nakagawa H., Ashida S., Nakamura Y.;
RT "Overexpressing gene in prostate cancer.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q6ZU67-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZU67-2; Sequence=VSP_016490, VSP_016491;
CC Name=3;
CC IsoId=Q6ZU67-3; Sequence=VSP_016488, VSP_016489, VSP_016492,
CC VSP_016493;
CC Name=4;
CC IsoId=Q6ZU67-4; Sequence=VSP_036338;
CC Name=5;
CC IsoId=Q6ZU67-5; Sequence=VSP_036338, VSP_016490, VSP_016491;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI28593.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI28594.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD93191.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD93192.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB126828; BAD93191.1; ALT_INIT; mRNA.
DR EMBL; AB126829; BAD93192.1; ALT_INIT; mRNA.
DR EMBL; AK125953; BAC86359.1; -; mRNA.
DR EMBL; AC111006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128592; AAI28593.1; ALT_INIT; mRNA.
DR EMBL; BC128593; AAI28594.1; ALT_INIT; mRNA.
DR CCDS; CCDS47048.1; -. [Q6ZU67-1]
DR RefSeq; NP_001153019.1; NM_001159547.1. [Q6ZU67-2]
DR RefSeq; NP_997289.2; NM_207406.3. [Q6ZU67-1]
DR RefSeq; XP_016863674.1; XM_017008185.1. [Q6ZU67-1]
DR AlphaFoldDB; Q6ZU67; -.
DR SMR; Q6ZU67; -.
DR BioGRID; 133036; 1.
DR IntAct; Q6ZU67; 2.
DR MINT; Q6ZU67; -.
DR STRING; 9606.ENSP00000421169; -.
DR iPTMnet; Q6ZU67; -.
DR PhosphoSitePlus; Q6ZU67; -.
DR BioMuta; BEND4; -.
DR DMDM; 327478588; -.
DR EPD; Q6ZU67; -.
DR MassIVE; Q6ZU67; -.
DR PaxDb; Q6ZU67; -.
DR PeptideAtlas; Q6ZU67; -.
DR PRIDE; Q6ZU67; -.
DR ProteomicsDB; 68315; -. [Q6ZU67-1]
DR ProteomicsDB; 68316; -. [Q6ZU67-2]
DR ProteomicsDB; 68317; -. [Q6ZU67-3]
DR ProteomicsDB; 68318; -. [Q6ZU67-4]
DR ProteomicsDB; 68319; -. [Q6ZU67-5]
DR Antibodypedia; 23689; 127 antibodies from 26 providers.
DR DNASU; 389206; -.
DR Ensembl; ENST00000502486.6; ENSP00000421169.1; ENSG00000188848.17. [Q6ZU67-1]
DR GeneID; 389206; -.
DR KEGG; hsa:389206; -.
DR MANE-Select; ENST00000502486.6; ENSP00000421169.1; NM_207406.4; NP_997289.2.
DR UCSC; uc003gwn.4; human. [Q6ZU67-1]
DR CTD; 389206; -.
DR DisGeNET; 389206; -.
DR GeneCards; BEND4; -.
DR HGNC; HGNC:23815; BEND4.
DR HPA; ENSG00000188848; Tissue enhanced (brain, prostate, testis).
DR neXtProt; NX_Q6ZU67; -.
DR OpenTargets; ENSG00000188848; -.
DR PharmGKB; PA164716541; -.
DR VEuPathDB; HostDB:ENSG00000188848; -.
DR eggNOG; ENOG502QUMQ; Eukaryota.
DR GeneTree; ENSGT00390000014963; -.
DR InParanoid; Q6ZU67; -.
DR OMA; PCETRPS; -.
DR OrthoDB; 538137at2759; -.
DR PhylomeDB; Q6ZU67; -.
DR TreeFam; TF332060; -.
DR PathwayCommons; Q6ZU67; -.
DR SignaLink; Q6ZU67; -.
DR BioGRID-ORCS; 389206; 8 hits in 1062 CRISPR screens.
DR ChiTaRS; BEND4; human.
DR GenomeRNAi; 389206; -.
DR Pharos; Q6ZU67; Tdark.
DR PRO; PR:Q6ZU67; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q6ZU67; protein.
DR Bgee; ENSG00000188848; Expressed in ventricular zone and 64 other tissues.
DR ExpressionAtlas; Q6ZU67; baseline and differential.
DR Genevisible; Q6ZU67; HS.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR InterPro; IPR018379; BEN_domain.
DR InterPro; IPR038950; BEND4.
DR PANTHER; PTHR35082; PTHR35082; 1.
DR Pfam; PF10523; BEN; 1.
DR SMART; SM01025; BEN; 1.
DR PROSITE; PS51457; BEN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..534
FT /note="BEN domain-containing protein 4"
FT /id="PRO_0000076190"
FT DOMAIN 390..498
FT /note="BEN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 324..351
FT /evidence="ECO:0000255"
FT COMPBIAS 50..65
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..78
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016488"
FT VAR_SEQ 33..157
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_036338"
FT VAR_SEQ 79..93
FT /note="QFQAQSSYPPGPGRA -> MQGAPRARFGSRTPP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016489"
FT VAR_SEQ 440..441
FT /note="SV -> IH (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_016490"
FT VAR_SEQ 442..534
FT /note="Missing (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_016491"
FT VAR_SEQ 463..494
FT /note="EFIRMHCTSNPDWWMPSEEQINKVFSDAVGHA -> GTASFRSVSPSVISFH
FT RIGCGSPRTSVQPSVF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016492"
FT VAR_SEQ 495..534
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016493"
SQ SEQUENCE 534 AA; 58375 MW; 0D7D1869A0796B26 CRC64;
MEEEMQPAEE GPSVPKIYKQ RSPYSVLKTF PSKRPALAKR YERPTLVELP HVRAPPPPPP
PFAPHAAVSI SSSEPPPQQF QAQSSYPPGP GRAAAAASSS SPSCTPATSQ GHLRTPAQPP
PASPAASSSS SFAAVVRYGP GAAAAAGTGG TGSDSASLEL SAESRMILDA FAQQCSRVLS
LLNCGGKLLD SNHSQSMISC VKQEGSSYNE RQEHCHIGKG VHSQTSDNVD IEMQYMQRKQ
QTSAFLRVFT DSLQNYLLSG SFPTPNPSSA SEYGHLADVD PLSTSPVHTL GGWTSPATSE
SHGHPSSSTL PEEEEEEDEE GYCPRCQELE QEVISLQQEN EELRRKLESI PVPCQTVLDY
LKMVLQHHNQ LLIPQPADQP TEGSKQLLNN YPVYITSKQW DEAVNSSKKD GRRLLRYLIR
FVFTTDELKY SCGLGKRKRS VQSGETGPER RPLDPVKVTC LREFIRMHCT SNPDWWMPSE
EQINKVFSDA VGHARQGRAV GTFLHNGGSF YEGIDHQASQ DEVFNKSSQD GSGD
