S2533_BOVIN
ID S2533_BOVIN Reviewed; 321 AA.
AC Q1LZB3;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Solute carrier family 25 member 33;
GN Name=SLC25A33;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hippocampus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial transporter that imports/exports pyrimidine
CC nucleotides into and from mitochondria. Transports preferentially
CC uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates
CC by an antiport mechanism. Also transports guanine but not adenine
CC (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate,
CC 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury
CC dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in
CC mitochondrial genome maintenance, regulation of mitochondrial membrane
CC potential and mitochondrial respiration. Upon INS or IGF1 stimulation
CC regulates cell growth and proliferation by controlling mitochondrial
CC DNA replication and transcription, the ratio of mitochondria-to
CC nuclear-encoded components of the electron transport chain resulting in
CC control of mitochondrial ROS production. Participates in dendritic cell
CC endocytosis and may associate with mitochondrial oxidative
CC phosphorylation. {ECO:0000250|UniProtKB:Q9BSK2}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9BSK2}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC116108; AAI16109.1; -; mRNA.
DR RefSeq; XP_010811602.1; XM_010813300.1.
DR RefSeq; XP_010821400.1; XM_010823098.2.
DR AlphaFoldDB; Q1LZB3; -.
DR SMR; Q1LZB3; -.
DR STRING; 9913.ENSBTAP00000004127; -.
DR PaxDb; Q1LZB3; -.
DR PRIDE; Q1LZB3; -.
DR Ensembl; ENSBTAT00000004127; ENSBTAP00000004127; ENSBTAG00000003177.
DR GeneID; 533794; -.
DR KEGG; bta:533794; -.
DR CTD; 84275; -.
DR VEuPathDB; HostDB:ENSBTAG00000003177; -.
DR VGNC; VGNC:34759; SLC25A33.
DR eggNOG; KOG0757; Eukaryota.
DR GeneTree; ENSGT00940000158954; -.
DR HOGENOM; CLU_015166_6_0_1; -.
DR InParanoid; Q1LZB3; -.
DR OMA; PTWAVYM; -.
DR OrthoDB; 1372287at2759; -.
DR TreeFam; TF314220; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000003177; Expressed in retina and 104 other tissues.
DR ExpressionAtlas; Q1LZB3; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0015218; F:pyrimidine nucleotide transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB.
DR GO; GO:1990314; P:cellular response to insulin-like growth factor stimulus; ISS:UniProtKB.
DR GO; GO:0031930; P:mitochondria-nucleus signaling pathway; ISS:UniProtKB.
DR GO; GO:0000002; P:mitochondrial genome maintenance; ISS:UniProtKB.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR GO; GO:0006390; P:mitochondrial transcription; ISS:UniProtKB.
DR GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:1990519; P:pyrimidine nucleotide import into mitochondrion; ISS:UniProtKB.
DR GO; GO:0006864; P:pyrimidine nucleotide transport; ISS:UniProtKB.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; ISS:UniProtKB.
DR GO; GO:0002082; P:regulation of oxidative phosphorylation; ISS:UniProtKB.
DR GO; GO:1903426; P:regulation of reactive oxygen species biosynthetic process; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..321
FT /note="Solute carrier family 25 member 33"
FT /id="PRO_0000291784"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..65
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 9..118
FT /note="Solcar 1"
FT REPEAT 126..213
FT /note="Solcar 2"
FT REPEAT 231..315
FT /note="Solcar 3"
SQ SEQUENCE 321 AA; 35378 MW; 88FED5CFB45CE1EE CRC64;
MATGTQQKEN TLLHLFAGGC GGTVGAIFTC PLEVIKTRLQ SSRLALRTVY YPQVHLGTIS
GAGVVRQTSV TPGLLQVLKS ILEKEGPRSL FRGLGPNLVG VAPSRAVYFA CYSKAKEQFN
GVFVPNSNIV HVFSAGSAAF VTNSLMNPIW MVKTRMQLER KVRGSKQMNT LQCARYVYQT
EGIRGFYRGL TASYAGISET IICFAIYESL KKYLKEAPLA SSTNGTEKNS TNFFGLMAAA
ALSKGCASCV AYPHEVIRTR LREEGSKYKS FVQTARLVFR EEGYLAFYRG LFAQLIRQIP
NTAIVLSTYE LIVYLLEDHA Q
