ID   S2533_DANRE             Reviewed;         314 AA.
AC   Q6P036;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Solute carrier family 25 member 33;
GN   Name=slc25a33; ORFNames=zgc:65787;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial transporter that imports/exports pyrimidine
CC       nucleotides into and from mitochondria which participates in dendritic
CC       cell endocytosis. {ECO:0000250|UniProtKB:Q9BSK2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BSK2}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC065854; AAH65854.1; -; mRNA.
DR   EMBL; BC056716; AAH56716.1; -; mRNA.
DR   RefSeq; NP_998322.1; NM_213157.1.
DR   AlphaFoldDB; Q6P036; -.
DR   SMR; Q6P036; -.
DR   STRING; 7955.ENSDARP00000058406; -.
DR   PaxDb; Q6P036; -.
DR   Ensembl; ENSDART00000058407; ENSDARP00000058406; ENSDARG00000039931.
DR   GeneID; 406436; -.
DR   KEGG; dre:406436; -.
DR   CTD; 84275; -.
DR   ZFIN; ZDB-GENE-040426-2183; slc25a33.
DR   eggNOG; KOG0757; Eukaryota.
DR   GeneTree; ENSGT00940000158954; -.
DR   HOGENOM; CLU_015166_6_0_1; -.
DR   InParanoid; Q6P036; -.
DR   OMA; PTWAVYM; -.
DR   OrthoDB; 1372287at2759; -.
DR   PhylomeDB; Q6P036; -.
DR   TreeFam; TF314220; -.
DR   PRO; PR:Q6P036; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000039931; Expressed in cleaving embryo and 33 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0015218; F:pyrimidine nucleotide transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IBA:GO_Central.
DR   GO; GO:1990519; P:pyrimidine nucleotide import into mitochondrion; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..314
FT                   /note="Solute carrier family 25 member 33"
FT                   /id="PRO_0000291787"
FT   TRANSMEM        7..27
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..58
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          4..111
FT                   /note="Solcar 1"
FT   REPEAT          119..206
FT                   /note="Solcar 2"
FT   REPEAT          224..308
FT                   /note="Solcar 3"
SQ   SEQUENCE   314 AA;  34488 MW;  B17F45B8DC39FBA2 CRC64;
     MAQKDTLLHL FAGGCGGTVG AIMTCPLEVL KTRLQSSGLT LRPVFQVQLG TLNGAGVIRP
     GSVTPGLLQV LRSILEKEGP RSLFRGLGPN LVGVAPSRAI YFAAYSKSKE TFNGIFVPNS
     GVVHMSSAGF AAFITNSLMN PIWMVKTRMQ LEKKARGEKK MNALQCARYV YKTEGMRGFY
     RGLTASYAGI SETMICFLIY ETLKKYLAQS RFTTPDTDND KGASDFLGLM FAAAFAKGCA
     SCIAYPHEVI RTRLREEGSK YKYFFQTARL VAVEEGYAAF YRGLIPQLIR QIPNTAIVLS
     TYELIVHLLA EPSK