S2534_HUMAN
ID S2534_HUMAN Reviewed; 304 AA.
AC Q6PIV7; Q68DV0;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Solute carrier family 25 member 34;
GN Name=SLC25A34;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 198-304.
RC TISSUE=Brain cortex;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP IDENTIFICATION.
RX PubMed=16949250; DOI=10.1016/j.ygeno.2006.06.016;
RA Haitina T., Lindblom J., Renstroem T., Fredriksson R.;
RT "Fourteen novel human members of mitochondrial solute carrier family 25
RT (SLC25) widely expressed in the central nervous system.";
RL Genomics 88:779-790(2006).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AL450998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027998; AAH27998.1; -; mRNA.
DR EMBL; CR749264; CAH18120.1; -; mRNA.
DR CCDS; CCDS162.1; -.
DR RefSeq; NP_997231.1; NM_207348.2.
DR AlphaFoldDB; Q6PIV7; -.
DR SMR; Q6PIV7; -.
DR BioGRID; 129941; 3.
DR STRING; 9606.ENSP00000294454; -.
DR TCDB; 2.A.29.15.3; the mitochondrial carrier (mc) family.
DR BioMuta; SLC25A34; -.
DR DMDM; 74758372; -.
DR MassIVE; Q6PIV7; -.
DR PaxDb; Q6PIV7; -.
DR PeptideAtlas; Q6PIV7; -.
DR PRIDE; Q6PIV7; -.
DR ProteomicsDB; 67181; -.
DR Antibodypedia; 28971; 56 antibodies from 18 providers.
DR DNASU; 284723; -.
DR Ensembl; ENST00000294454.6; ENSP00000294454.5; ENSG00000162461.8.
DR GeneID; 284723; -.
DR KEGG; hsa:284723; -.
DR MANE-Select; ENST00000294454.6; ENSP00000294454.5; NM_207348.3; NP_997231.1.
DR UCSC; uc001axb.2; human.
DR CTD; 284723; -.
DR GeneCards; SLC25A34; -.
DR HGNC; HGNC:27653; SLC25A34.
DR HPA; ENSG00000162461; Tissue enhanced (skeletal muscle, tongue).
DR MIM; 610817; gene.
DR neXtProt; NX_Q6PIV7; -.
DR OpenTargets; ENSG00000162461; -.
DR PharmGKB; PA142670906; -.
DR VEuPathDB; HostDB:ENSG00000162461; -.
DR eggNOG; KOG0755; Eukaryota.
DR GeneTree; ENSGT00940000160016; -.
DR HOGENOM; CLU_015166_14_3_1; -.
DR InParanoid; Q6PIV7; -.
DR OMA; KANCEDH; -.
DR OrthoDB; 1013743at2759; -.
DR PhylomeDB; Q6PIV7; -.
DR TreeFam; TF324506; -.
DR PathwayCommons; Q6PIV7; -.
DR SignaLink; Q6PIV7; -.
DR BioGRID-ORCS; 284723; 12 hits in 1070 CRISPR screens.
DR GenomeRNAi; 284723; -.
DR Pharos; Q6PIV7; Tdark.
DR PRO; PR:Q6PIV7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6PIV7; protein.
DR Bgee; ENSG00000162461; Expressed in vastus lateralis and 120 other tissues.
DR Genevisible; Q6PIV7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..304
FT /note="Solute carrier family 25 member 34"
FT /id="PRO_0000291789"
FT TRANSMEM 7..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..191
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..301
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 4..97
FT /note="Solcar 1"
FT REPEAT 101..194
FT /note="Solcar 2"
FT REPEAT 204..295
FT /note="Solcar 3"
FT CONFLICT 198
FT /note="Q -> P (in Ref. 3; CAH18120)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 304 AA; 32224 MW; 1C35741714D219ED CRC64;
METVPPAVDL VLGASACCLA CVFTNPLEVV KTRLQLQGEL QARGTYPRPY HGFIASVAAV
ARADGLWGLQ KGLAAGLLYQ GLMNGVRFYC YSLACQAGLT QQPGGTVVAG AVAGALGAFV
GSPAYLIKTQ LQAQTVAAVA VGHQHNHQTV LGALETIWRQ QGLLGLWQGV GGAVPRVMVG
SAAQLATFAS AKAWVQKQQW LPEDSWLVAL AGGMISSIAV VVVMTPFDVV STRLYNQPVD
TAGRGQLYGG LTDCMVKIWR QEGPLALYKG LGPAYLRLGP HTILSMLFWD ELRKLAGRAQ
HKGT
