S2534_MOUSE
ID S2534_MOUSE Reviewed; 318 AA.
AC A2ADF7; Q5FW51;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Solute carrier family 25 member 34;
GN Name=Slc25a34; Synonyms=Gm1369;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2ADF7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2ADF7-2; Sequence=VSP_026235, VSP_026236;
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AL670446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC089627; AAH89627.2; -; mRNA.
DR CCDS; CCDS18878.1; -. [A2ADF7-1]
DR RefSeq; NP_001013802.1; NM_001013780.1. [A2ADF7-1]
DR AlphaFoldDB; A2ADF7; -.
DR SMR; A2ADF7; -.
DR STRING; 10090.ENSMUSP00000039188; -.
DR PaxDb; A2ADF7; -.
DR PRIDE; A2ADF7; -.
DR ProteomicsDB; 253372; -. [A2ADF7-1]
DR ProteomicsDB; 253373; -. [A2ADF7-2]
DR Antibodypedia; 28971; 56 antibodies from 18 providers.
DR Ensembl; ENSMUST00000038661; ENSMUSP00000039188; ENSMUSG00000040740. [A2ADF7-1]
DR GeneID; 384071; -.
DR KEGG; mmu:384071; -.
DR UCSC; uc008vox.1; mouse. [A2ADF7-1]
DR UCSC; uc008voy.1; mouse. [A2ADF7-2]
DR CTD; 284723; -.
DR MGI; MGI:2686215; Slc25a34.
DR VEuPathDB; HostDB:ENSMUSG00000040740; -.
DR eggNOG; KOG0755; Eukaryota.
DR GeneTree; ENSGT00940000160016; -.
DR HOGENOM; CLU_015166_14_3_1; -.
DR InParanoid; A2ADF7; -.
DR OMA; KANCEDH; -.
DR OrthoDB; 1013743at2759; -.
DR PhylomeDB; A2ADF7; -.
DR TreeFam; TF324506; -.
DR BioGRID-ORCS; 384071; 3 hits in 72 CRISPR screens.
DR PRO; PR:A2ADF7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2ADF7; protein.
DR Bgee; ENSMUSG00000040740; Expressed in hindlimb stylopod muscle and 39 other tissues.
DR Genevisible; A2ADF7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0001835; P:blastocyst hatching; IMP:MGI.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..318
FT /note="Solute carrier family 25 member 34"
FT /id="PRO_0000291790"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..205
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..315
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 18..111
FT /note="Solcar 1"
FT REPEAT 115..208
FT /note="Solcar 2"
FT REPEAT 218..309
FT /note="Solcar 3"
FT VAR_SEQ 214..219
FT /note="WFLEDS -> VRSWEH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026235"
FT VAR_SEQ 220..318
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026236"
SQ SEQUENCE 318 AA; 33778 MW; 0FC61CE7065CE4D6 CRC64;
MKPTQAQMAP AMDSREMVSP AVDLVLGASA CCLACVFTNP LEVVKTRLQL QGELQAPGTY
PRPYRGFVSS VAAVARADGL WGLQKGLAAG LLYQGLMNGV RFYCYSLACQ AGLTQQPGGT
VVAGAAAGAL GAFVGSPAYL VKTQLQAQTV ATMAVGHQHQ HQGVLSALET IWRQQGMLGL
WRGVGGAVPR VTVGSAAQLA TFTSAKAWVQ DRQWFLEDSW LVTLAGGMIS SIAVVAVMTP
LDVVSTRLYN QPVDRAGRGQ LYGGLADCLV KTCQQEGPLA LYKGLGPAYL RLGPHTILSM
FFWDELRKLV ARAQHQGT
