S2535_HUMAN
ID S2535_HUMAN Reviewed; 300 AA.
AC Q3KQZ1; Q494X5; Q6RGS3; Q8N7Y5;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Solute carrier family 25 member 35;
GN Name=SLC25A35;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RA Zhou G., Zhong G., Ke R., Li H., Shen C., Lin L., Yang S.;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=16949250; DOI=10.1016/j.ygeno.2006.06.016;
RA Haitina T., Lindblom J., Renstroem T., Fredriksson R.;
RT "Fourteen novel human members of mitochondrial solute carrier family 25
RT (SLC25) widely expressed in the central nervous system.";
RL Genomics 88:779-790(2006).
CC -!- INTERACTION:
CC Q3KQZ1-4; P0DI81-3: TRAPPC2; NbExp=3; IntAct=EBI-13054652, EBI-11961968;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q3KQZ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3KQZ1-2; Sequence=VSP_026239;
CC Name=3;
CC IsoId=Q3KQZ1-3; Sequence=VSP_026238, VSP_026239;
CC Name=4;
CC IsoId=Q3KQZ1-4; Sequence=VSP_026237;
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY498866; AAR92153.1; -; mRNA.
DR EMBL; AK097536; BAC05091.1; -; mRNA.
DR EMBL; BC101329; AAI01330.2; -; mRNA.
DR EMBL; BC101330; AAI01331.1; -; mRNA.
DR EMBL; BC105995; AAI05996.1; -; mRNA.
DR CCDS; CCDS11138.1; -. [Q3KQZ1-4]
DR CCDS; CCDS82067.1; -. [Q3KQZ1-1]
DR RefSeq; NP_001307799.1; NM_001320870.1. [Q3KQZ1-1]
DR RefSeq; NP_001307800.1; NM_001320871.1. [Q3KQZ1-4]
DR RefSeq; NP_001307801.1; NM_001320872.1. [Q3KQZ1-4]
DR RefSeq; NP_958928.1; NM_201520.2. [Q3KQZ1-4]
DR RefSeq; XP_011522148.1; XM_011523846.1. [Q3KQZ1-2]
DR AlphaFoldDB; Q3KQZ1; -.
DR SMR; Q3KQZ1; -.
DR BioGRID; 134361; 16.
DR IntAct; Q3KQZ1; 6.
DR STRING; 9606.ENSP00000369407; -.
DR TCDB; 2.A.29.15.2; the mitochondrial carrier (mc) family.
DR iPTMnet; Q3KQZ1; -.
DR PhosphoSitePlus; Q3KQZ1; -.
DR BioMuta; SLC25A35; -.
DR DMDM; 121942600; -.
DR EPD; Q3KQZ1; -.
DR jPOST; Q3KQZ1; -.
DR MassIVE; Q3KQZ1; -.
DR MaxQB; Q3KQZ1; -.
DR PaxDb; Q3KQZ1; -.
DR PeptideAtlas; Q3KQZ1; -.
DR PRIDE; Q3KQZ1; -.
DR ProteomicsDB; 61730; -. [Q3KQZ1-1]
DR ProteomicsDB; 61731; -. [Q3KQZ1-2]
DR ProteomicsDB; 61732; -. [Q3KQZ1-3]
DR ProteomicsDB; 61733; -. [Q3KQZ1-4]
DR Antibodypedia; 24621; 68 antibodies from 15 providers.
DR DNASU; 399512; -.
DR Ensembl; ENST00000380067.6; ENSP00000369407.2; ENSG00000125434.11. [Q3KQZ1-4]
DR Ensembl; ENST00000577745.2; ENSP00000464231.1; ENSG00000125434.11. [Q3KQZ1-1]
DR Ensembl; ENST00000579192.5; ENSP00000462395.1; ENSG00000125434.11. [Q3KQZ1-4]
DR Ensembl; ENST00000579681.5; ENSP00000464307.1; ENSG00000125434.11. [Q3KQZ1-3]
DR Ensembl; ENST00000580340.5; ENSP00000464071.1; ENSG00000125434.11. [Q3KQZ1-4]
DR Ensembl; ENST00000585311.5; ENSP00000464191.1; ENSG00000125434.11. [Q3KQZ1-2]
DR GeneID; 399512; -.
DR KEGG; hsa:399512; -.
DR MANE-Select; ENST00000577745.2; ENSP00000464231.1; NM_001320870.2; NP_001307799.1.
DR UCSC; uc002gkt.4; human. [Q3KQZ1-1]
DR CTD; 399512; -.
DR DisGeNET; 399512; -.
DR GeneCards; SLC25A35; -.
DR HGNC; HGNC:31921; SLC25A35.
DR HPA; ENSG00000125434; Low tissue specificity.
DR MIM; 610818; gene.
DR neXtProt; NX_Q3KQZ1; -.
DR OpenTargets; ENSG00000125434; -.
DR PharmGKB; PA142670907; -.
DR VEuPathDB; HostDB:ENSG00000125434; -.
DR eggNOG; KOG0755; Eukaryota.
DR GeneTree; ENSGT00940000160771; -.
DR HOGENOM; CLU_015166_14_3_1; -.
DR InParanoid; Q3KQZ1; -.
DR OMA; VMSRMYN; -.
DR OrthoDB; 1013743at2759; -.
DR PhylomeDB; Q3KQZ1; -.
DR TreeFam; TF324506; -.
DR PathwayCommons; Q3KQZ1; -.
DR SignaLink; Q3KQZ1; -.
DR BioGRID-ORCS; 399512; 10 hits in 1081 CRISPR screens.
DR ChiTaRS; SLC25A35; human.
DR GenomeRNAi; 399512; -.
DR Pharos; Q3KQZ1; Tdark.
DR PRO; PR:Q3KQZ1; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q3KQZ1; protein.
DR Bgee; ENSG00000125434; Expressed in left testis and 129 other tissues.
DR Genevisible; Q3KQZ1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..300
FT /note="Solute carrier family 25 member 35"
FT /id="PRO_0000291794"
FT TRANSMEM 38..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..300
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 1..90
FT /note="Solcar 1"
FT REPEAT 100..193
FT /note="Solcar 2"
FT REPEAT 203..294
FT /note="Solcar 3"
FT VAR_SEQ 244..300
FT /note="GLMYRGILDALLQTARTEGIFGMYKGIGASYFRLGPHTILSLFFWDQLRSLY
FT YTDTK -> NRVPKFSATSCSASAPLLGTKDVRIVKGQTGHQLFKVTQAPGCSPILLGT
FT QS (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_026237"
FT VAR_SEQ 265..268
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_026238"
FT VAR_SEQ 269..300
FT /note="GIGASYFRLGPHTILSLFFWDQLRSLYYTDTK -> EPSPQVLSNIMQCFSA
FT FTGDQRC (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_026239"
FT CONFLICT 79
FT /note="I -> V (in Ref. 1; AAR92153)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 32438 MW; 21F86F522C831A4D CRC64;
MDFLMSGLAA CGACVFTNPL EVVKTRMQLQ GELQAPGTYQ RHYRNVFHAF ITIGKVDGLA
ALQKGLAPAL LYQFLMNGIR LGTYGLAEAG GYLHTAEGTH SPARSAAAGA MAGVMGAYLG
SPIYMVKTHL QAQAASEIAV GHQYKHQGMF QALTEIGQKH GLVGLWRGAL GGLPRVIVGS
STQLCTFSST KDLLSQWEIF PPQSWKLALV AAMMSGIAVV LAMAPFDVAC TRLYNQPTDA
QGKGLMYRGI LDALLQTART EGIFGMYKGI GASYFRLGPH TILSLFFWDQ LRSLYYTDTK
