S2535_MOUSE
ID S2535_MOUSE Reviewed; 300 AA.
AC Q5SWT3; Q3TBP2; Q99KM5; Q9D913;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Solute carrier family 25 member 35;
GN Name=Slc25a35;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH04569.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAI25535.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK007453; BAB25048.1; -; mRNA.
DR EMBL; AK171131; BAE42267.1; -; mRNA.
DR EMBL; AL603662; CAI25535.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL603662; CAI25536.1; -; Genomic_DNA.
DR EMBL; BC004569; AAH04569.1; ALT_INIT; mRNA.
DR EMBL; BC019996; AAH19996.1; -; mRNA.
DR CCDS; CCDS24874.1; -.
DR RefSeq; NP_082324.1; NM_028048.2.
DR RefSeq; XP_006534336.1; XM_006534273.2.
DR AlphaFoldDB; Q5SWT3; -.
DR SMR; Q5SWT3; -.
DR IntAct; Q5SWT3; 1.
DR STRING; 10090.ENSMUSP00000099666; -.
DR iPTMnet; Q5SWT3; -.
DR PhosphoSitePlus; Q5SWT3; -.
DR EPD; Q5SWT3; -.
DR jPOST; Q5SWT3; -.
DR MaxQB; Q5SWT3; -.
DR PaxDb; Q5SWT3; -.
DR PeptideAtlas; Q5SWT3; -.
DR PRIDE; Q5SWT3; -.
DR ProteomicsDB; 256862; -.
DR Antibodypedia; 24621; 68 antibodies from 15 providers.
DR DNASU; 71998; -.
DR Ensembl; ENSMUST00000102606; ENSMUSP00000099666; ENSMUSG00000018740.
DR GeneID; 71998; -.
DR KEGG; mmu:71998; -.
DR UCSC; uc007jop.1; mouse.
DR CTD; 399512; -.
DR MGI; MGI:1919248; Slc25a35.
DR VEuPathDB; HostDB:ENSMUSG00000018740; -.
DR eggNOG; KOG0755; Eukaryota.
DR GeneTree; ENSGT00940000160771; -.
DR InParanoid; Q5SWT3; -.
DR OMA; VMSRMYN; -.
DR OrthoDB; 1013743at2759; -.
DR PhylomeDB; Q5SWT3; -.
DR TreeFam; TF324506; -.
DR BioGRID-ORCS; 71998; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Slc25a35; mouse.
DR PRO; PR:Q5SWT3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5SWT3; protein.
DR Bgee; ENSMUSG00000018740; Expressed in olfactory epithelium and 141 other tissues.
DR ExpressionAtlas; Q5SWT3; baseline and differential.
DR Genevisible; Q5SWT3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..300
FT /note="Solute carrier family 25 member 35"
FT /id="PRO_0000291795"
FT TRANSMEM 38..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..300
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 1..90
FT /note="Solcar 1"
FT REPEAT 100..193
FT /note="Solcar 2"
FT REPEAT 203..294
FT /note="Solcar 3"
SQ SEQUENCE 300 AA; 32631 MW; D7D6C151D7ED4AA3 CRC64;
MDFLMSGVAA CGACVFTNPL EVVKTRMQLQ GELQAPGTYQ RHYRNVFHAF FTIGKVDGLA
ALQKGLGPAL LYQFLMNGIR LGTYGLAESR GYLHTNEGTH SPVRSAAAGA LAGVMGAYLG
SPIYMVKTHL QAQAASEIAV GHQYKHQGMF QALTEIGQKH GLVGLWRGAV GGLPRVVIGS
STQLCTFSSI KDLLSQWEIF PPQSWKVALA AAMVSGVAIV VAMTPFDVAS TRLYNQPTDT
RGKGLMYRGI LDALLQTART EGFFGMYKGI GASYFRLGPH TILSLFFWDQ LRSFYNTYAK
