S2536_MOUSE
ID S2536_MOUSE Reviewed; 311 AA.
AC Q922G0;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Solute carrier family 25 member 36;
GN Name=Slc25a36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mitochondrial transporter that imports/exports pyrimidine
CC nucleotides into and from mitochondria. Transports preferentially
CC cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by
CC uniport and antiport mechanism. Also transports guanine but not adenine
CC (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate,
CC 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury
CC dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in
CC mitochondrial genome maintenance, regulation of mitochondrial membrane
CC potential and mitochondrial respiration.
CC {ECO:0000250|UniProtKB:Q96CQ1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q96CQ1}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AK042075; BAE20619.1; -; mRNA.
DR EMBL; AK053646; BAC35461.1; -; mRNA.
DR EMBL; AK078779; BAC37391.1; -; mRNA.
DR EMBL; BC008171; AAH08171.1; -; mRNA.
DR CCDS; CCDS23420.1; -.
DR RefSeq; NP_620095.1; NM_138756.4.
DR AlphaFoldDB; Q922G0; -.
DR SMR; Q922G0; -.
DR BioGRID; 228686; 2.
DR STRING; 10090.ENSMUSP00000082302; -.
DR iPTMnet; Q922G0; -.
DR PhosphoSitePlus; Q922G0; -.
DR SwissPalm; Q922G0; -.
DR EPD; Q922G0; -.
DR MaxQB; Q922G0; -.
DR PaxDb; Q922G0; -.
DR PeptideAtlas; Q922G0; -.
DR PRIDE; Q922G0; -.
DR ProteomicsDB; 253374; -.
DR Antibodypedia; 18006; 75 antibodies from 16 providers.
DR DNASU; 192287; -.
DR Ensembl; ENSMUST00000085206; ENSMUSP00000082302; ENSMUSG00000032449.
DR GeneID; 192287; -.
DR KEGG; mmu:192287; -.
DR UCSC; uc009rdb.1; mouse.
DR CTD; 55186; -.
DR MGI; MGI:1924909; Slc25a36.
DR VEuPathDB; HostDB:ENSMUSG00000032449; -.
DR eggNOG; KOG0757; Eukaryota.
DR GeneTree; ENSGT00940000154369; -.
DR HOGENOM; CLU_015166_6_0_1; -.
DR InParanoid; Q922G0; -.
DR OMA; HVHEGWR; -.
DR OrthoDB; 1372287at2759; -.
DR PhylomeDB; Q922G0; -.
DR TreeFam; TF314220; -.
DR BioGRID-ORCS; 192287; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Slc25a36; mouse.
DR PRO; PR:Q922G0; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q922G0; protein.
DR Bgee; ENSMUSG00000032449; Expressed in metanephric cortical collecting duct and 254 other tissues.
DR ExpressionAtlas; Q922G0; baseline and differential.
DR Genevisible; Q922G0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0015218; F:pyrimidine nucleotide transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0000002; P:mitochondrial genome maintenance; ISS:UniProtKB.
DR GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR GO; GO:1990519; P:pyrimidine nucleotide import into mitochondrion; IBA:GO_Central.
DR GO; GO:0006864; P:pyrimidine nucleotide transport; ISS:UniProtKB.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..311
FT /note="Solute carrier family 25 member 36"
FT /id="PRO_0000291798"
FT TRANSMEM 7..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..57
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 4..108
FT /note="Solcar 1"
FT REPEAT 116..203
FT /note="Solcar 2"
FT REPEAT 224..308
FT /note="Solcar 3"
SQ SEQUENCE 311 AA; 34170 MW; 955FFBD45BA78F48 CRC64;
MSQRDTLVHL FAGGCGGTVG AILTCPLEVV KTRLQSSSVT LYISEVQLNT MAGASVNRVV
SPGPLHCLKA ILEKEGPRSL FRGLGPNLVG VAPSRAIYFA AYSNCKEKLN GVFDPDSTQV
HMASAAMAGF TAITATNPIW LIKTRLQLDA RTRGEKQMGA FECVRKVYQT DGLRGFYRGM
SASYAGISET VIHFVIYESI KQKLLECKTA SMMETDEESV KEASDFVRMM LAAATSKTCA
TTIAYPHEVV RTRLREEGTK YRSFFQTLSL IVQEEGYGSL YRGLTTHLVR QIPNTAIMMA
TYELVVYLLN G
