BEND5_MOUSE
ID BEND5_MOUSE Reviewed; 421 AA.
AC Q8C6D4; Q3TJI2; Q80V74; Q80WB6; Q9CRW0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=BEN domain-containing protein 5;
GN Name=Bend5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Head, Placenta, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-421 (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a transcriptional repressor.
CC {ECO:0000250|UniProtKB:Q7L4P6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C6D4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C6D4-2; Sequence=VSP_022696;
CC -!- DOMAIN: The BEN domain mediates DNA-binding.
CC {ECO:0000250|UniProtKB:Q7L4P6}.
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DR EMBL; AK014057; BAB29136.1; -; mRNA.
DR EMBL; AK075885; BAC36030.1; -; mRNA.
DR EMBL; AK156708; BAE33814.1; -; mRNA.
DR EMBL; AK167425; BAE39513.1; -; mRNA.
DR EMBL; BC037633; AAH37633.1; -; mRNA.
DR EMBL; BC051512; AAH51512.1; -; mRNA.
DR CCDS; CCDS18472.1; -. [Q8C6D4-1]
DR RefSeq; NP_080555.1; NM_026279.3. [Q8C6D4-1]
DR RefSeq; XP_011238896.1; XM_011240594.2. [Q8C6D4-2]
DR RefSeq; XP_017175855.1; XM_017320366.1. [Q8C6D4-2]
DR AlphaFoldDB; Q8C6D4; -.
DR SMR; Q8C6D4; -.
DR STRING; 10090.ENSMUSP00000030274; -.
DR iPTMnet; Q8C6D4; -.
DR PhosphoSitePlus; Q8C6D4; -.
DR MaxQB; Q8C6D4; -.
DR PaxDb; Q8C6D4; -.
DR PRIDE; Q8C6D4; -.
DR ProteomicsDB; 273481; -. [Q8C6D4-1]
DR ProteomicsDB; 273482; -. [Q8C6D4-2]
DR Antibodypedia; 53655; 69 antibodies from 24 providers.
DR DNASU; 67621; -.
DR Ensembl; ENSMUST00000030274; ENSMUSP00000030274; ENSMUSG00000028545. [Q8C6D4-1]
DR GeneID; 67621; -.
DR KEGG; mmu:67621; -.
DR UCSC; uc008ude.2; mouse. [Q8C6D4-1]
DR CTD; 79656; -.
DR MGI; MGI:1914871; Bend5.
DR VEuPathDB; HostDB:ENSMUSG00000028545; -.
DR eggNOG; ENOG502QTVS; Eukaryota.
DR GeneTree; ENSGT00390000001724; -.
DR HOGENOM; CLU_739568_0_0_1; -.
DR InParanoid; Q8C6D4; -.
DR OMA; HNTCPEE; -.
DR OrthoDB; 727836at2759; -.
DR PhylomeDB; Q8C6D4; -.
DR TreeFam; TF331898; -.
DR BioGRID-ORCS; 67621; 1 hit in 69 CRISPR screens.
DR PRO; PR:Q8C6D4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8C6D4; protein.
DR Bgee; ENSMUSG00000028545; Expressed in manus and 204 other tissues.
DR ExpressionAtlas; Q8C6D4; baseline and differential.
DR Genevisible; Q8C6D4; MM.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR InterPro; IPR018379; BEN_domain.
DR InterPro; IPR040391; BEND5.
DR PANTHER; PTHR14628; PTHR14628; 1.
DR Pfam; PF10523; BEN; 1.
DR SMART; SM01025; BEN; 1.
DR PROSITE; PS51457; BEN; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Coiled coil; DNA-binding;
KW Isopeptide bond; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..421
FT /note="BEN domain-containing protein 5"
FT /id="PRO_0000274280"
FT DOMAIN 302..408
FT /note="BEN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
FT COILED 180..243
FT /evidence="ECO:0000255"
FT MOD_RES 133
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q7L4P6"
FT CROSSLNK 258
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7L4P6"
FT VAR_SEQ 1..169
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022696"
SQ SEQUENCE 421 AA; 48227 MW; E693CF12282CD693 CRC64;
MYAFVRFLED NVCYALPVSC VRDFSPRSRL DFDNQKVYAV YRGPEELGAE PESPPRAPRD
WGALLLHKAQ ILALAEDKSD LENSVMQKKI KIPKLSLSHV EDDGEVKDYG EEDLQLRHIK
RPEGRKPSEA AHKSIEAVVA RLERQNGLSL GHSTCPEEVF VEASPGTEDM DSLEDAVVPR
ALYEELLRNY QQQQEEMRHL QQELERTRRQ LVQQAKKLKE YGALVSEMKE LRDLNRRLQD
VLLLRLGSGP AIDLEKVKSE CLEPEPELRS TFSEEANTSS YYPAPAPVMD KYILDNGKVH
LGSGIWVDEE KWHQLQVTQG DSKYTKNLAV MIWGTDVLKN RSVTGVATKK KKDAIPKPPL
SPHKLSIVRE CLYDRIAQET VDETEIAQRL SKVNKYICEK IMDINKSCKN EERREAKYNL
Q
