S2538_BOVIN
ID S2538_BOVIN Reviewed; 306 AA.
AC Q5EAC0; A6QLQ9; Q58CZ6; Q5E9P0; Q5E9V7; Q5EAB7;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Mitochondrial glycine transporter {ECO:0000255|HAMAP-Rule:MF_03064};
DE AltName: Full=Solute carrier family 25 member 38 {ECO:0000255|HAMAP-Rule:MF_03064};
GN Name=SLC25A38 {ECO:0000255|HAMAP-Rule:MF_03064};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC the mitochondrial matrix. Plays an important role in providing glycine
CC for the first enzymatic step in heme biosynthesis, the condensation of
CC glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC mitochondrial matrix. Required during erythropoiesis.
CC {ECO:0000255|HAMAP-Rule:MF_03064}.
CC -!- FUNCTION: Plays a role as pro-apoptotic protein that induces caspase-
CC dependent apoptosis. {ECO:0000250|UniProtKB:Q91XD8}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715,
CC ChEBI:CHEBI:57305; Evidence={ECO:0000250|UniProtKB:Q96DW6};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03064}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03064}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC SLC25A38 subfamily. {ECO:0000255|HAMAP-Rule:MF_03064}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX46648.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BT020649; AAX08666.1; -; mRNA.
DR EMBL; BT020652; AAX08669.1; -; mRNA.
DR EMBL; BT020813; AAX08830.1; -; mRNA.
DR EMBL; BT020880; AAX08897.1; -; mRNA.
DR EMBL; BT021801; AAX46648.1; ALT_FRAME; mRNA.
DR EMBL; BT026157; ABG66996.1; -; mRNA.
DR EMBL; BC148053; AAI48054.1; -; mRNA.
DR RefSeq; NP_001014905.2; NM_001014905.2.
DR AlphaFoldDB; Q5EAC0; -.
DR SMR; Q5EAC0; -.
DR STRING; 9913.ENSBTAP00000045521; -.
DR PaxDb; Q5EAC0; -.
DR Ensembl; ENSBTAT00000020606; ENSBTAP00000020606; ENSBTAG00000022721.
DR GeneID; 512325; -.
DR KEGG; bta:512325; -.
DR CTD; 54977; -.
DR VEuPathDB; HostDB:ENSBTAG00000022721; -.
DR VGNC; VGNC:34763; SLC25A38.
DR eggNOG; KOG0766; Eukaryota.
DR GeneTree; ENSGT00550000075117; -.
DR HOGENOM; CLU_015166_0_3_1; -.
DR InParanoid; Q5EAC0; -.
DR OMA; IRDAPYA; -.
DR OrthoDB; 1531343at2759; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000022721; Expressed in retina and 105 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0015187; F:glycine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR GO; GO:1904983; P:glycine import into mitochondrion; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR HAMAP; MF_03064; SLC25A38; 1.
DR InterPro; IPR030847; Hem25/SLC25A38.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..306
FT /note="Mitochondrial glycine transporter"
FT /id="PRO_0000291801"
FT TRANSMEM 31..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 89..115
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 127..152
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 180..203
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 221..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 276..294
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 25..114
FT /note="Solcar 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 121..205
FT /note="Solcar 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 217..301
FT /note="Solcar 3"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT CONFLICT 63
FT /note="H -> R (in Ref. 1; AAX08897)"
FT /evidence="ECO:0000305"
FT CONFLICT 65..66
FT /note="Missing (in Ref. 1; AAX08897)"
FT /evidence="ECO:0000305"
FT CONFLICT 144..145
FT /note="IT -> SA (in Ref. 1; AAX08830)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="E -> K (in Ref. 1; AAX08669)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="V -> L (in Ref. 1; AAX46648/AAX08669/AAX08666/
FT ABG66996/AAX08897)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 306 AA; 33798 MW; 604E4B6090B5B1EA CRC64;
MIQKSRPALL QHQDVGDRVE TLMLQPVIKA FLCGSISGTC STLLFQPLDL LKTRLQTLQP
SAHGSRRVGM LALLLNVVRT ESPLGLWKGM SPSIVRCVPG VGIYFGTLYS LKQYFLRGHP
PTALESIILG AGSRSVAGVC MSPITVIKTR YESGRYGYES VYAALRSICH SEGFRGLFSG
LTATLLRDAP FSGIYLMFYS QTKNVVLHRT DQLDAVLVPV VNFSCGIFAG ILASLVTQPA
DVIKTHMQLF PMKFRWIGQS VTLIFKDYGL RGFFQGSVPR ALRRTLMAAM AWTVYEEMMA
KMGLKS
