ID   S2538_MAGO7             Reviewed;         334 AA.
AC   A4RPU0; G4MNJ1;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Mitochondrial glycine transporter {ECO:0000255|HAMAP-Rule:MF_03064};
DE   AltName: Full=Solute carrier family 25 member 38 homolog {ECO:0000255|HAMAP-Rule:MF_03064};
GN   ORFNames=MGG_05623;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC       the mitochondrial matrix. Plays an important role in providing glycine
CC       for the first enzymatic step in heme biosynthesis, the condensation of
CC       glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC       mitochondrial matrix. {ECO:0000255|HAMAP-Rule:MF_03064}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715,
CC         ChEBI:CHEBI:57305; Evidence={ECO:0000250|UniProtKB:Q96DW6};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03064}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03064}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       SLC25A38 subfamily. {ECO:0000255|HAMAP-Rule:MF_03064}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM001231; EHA57897.1; -; Genomic_DNA.
DR   RefSeq; XP_003710509.1; XM_003710461.1.
DR   AlphaFoldDB; A4RPU0; -.
DR   SMR; A4RPU0; -.
DR   STRING; 318829.MGG_05623T0; -.
DR   EnsemblFungi; MGG_05623T0; MGG_05623T0; MGG_05623.
DR   GeneID; 2676214; -.
DR   KEGG; mgr:MGG_05623; -.
DR   VEuPathDB; FungiDB:MGG_05623; -.
DR   eggNOG; KOG0766; Eukaryota.
DR   HOGENOM; CLU_015166_0_3_1; -.
DR   InParanoid; A4RPU0; -.
DR   OMA; IRDAPYA; -.
DR   OrthoDB; 1531343at2759; -.
DR   Proteomes; UP000009058; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015187; F:glycine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:1904983; P:glycine import into mitochondrion; IEA:UniProtKB-UniRule.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:EnsemblFungi.
DR   Gene3D; 1.50.40.10; -; 2.
DR   HAMAP; MF_03064; SLC25A38; 1.
DR   InterPro; IPR030847; Hem25/SLC25A38.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..334
FT                   /note="Mitochondrial glycine transporter"
FT                   /id="PRO_0000378938"
FT   TRANSMEM        16..41
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        69..95
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        133..158
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        186..209
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        238..264
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        293..311
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   REPEAT          10..94
FT                   /note="Solcar 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   REPEAT          127..211
FT                   /note="Solcar 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   REPEAT          234..318
FT                   /note="Solcar 3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
SQ   SEQUENCE   334 AA;  35586 MW;  FB42FD894835F341 CRC64;
     MSDGTSKSGS KSSFHFVAGL GSGVLSAALL QPIDLLKTRV QQSPHQNILR TVSEIRHTSP
     AGLRGLWRGT VPSALRTGFG SALYFSTLNA IRQAAVPLFA HDAAVTTSPN GGNFANNKNN
     SSRLVKLSNT GNLLAGGVAR GFAGFVLMPL TVIKVRYESS LYSYRSIAGA AGDILRTEGP
     RGFFAGFGAT ALRDAPYAGL YVLLYEQFKR RLGGVVSSSA APETNEDNRM GVSRAAAVNF
     SSGVLAAVAC SVVSNPFDAV KTRIQLRPGR YRNMVVAART MMAEEGARSF FSGLGLRMSR
     KALSSALAWT LYEELIMRAE VGWSLSSSRT ERAM