S2538_MOUSE
ID S2538_MOUSE Reviewed; 326 AA.
AC Q91XD8;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Mitochondrial glycine transporter {ECO:0000255|HAMAP-Rule:MF_03064};
DE AltName: Full=Appoptosin {ECO:0000303|PubMed:23115192};
DE AltName: Full=Solute carrier family 25 member 38 {ECO:0000255|HAMAP-Rule:MF_03064};
GN Name=Slc25a38 {ECO:0000255|HAMAP-Rule:MF_03064};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=23115192; DOI=10.1523/jneurosci.3668-12.2012;
RA Zhang H., Zhang Y.W., Chen Y., Huang X., Zhou F., Wang W., Xian B.,
RA Zhang X., Masliah E., Chen Q., Han J.D., Bu G., Reed J.C., Liao F.F.,
RA Chen Y.G., Xu H.;
RT "Appoptosin is a novel pro-apoptotic protein and mediates cell death in
RT neurodegeneration.";
RL J. Neurosci. 32:15565-15576(2012).
CC -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC the mitochondrial matrix. Plays an important role in providing glycine
CC for the first enzymatic step in heme biosynthesis, the condensation of
CC glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC mitochondrial matrix. Required during erythropoiesis.
CC {ECO:0000255|HAMAP-Rule:MF_03064}.
CC -!- FUNCTION: Plays a role as pro-apoptotic protein that induces caspase-
CC dependent apoptosis. {ECO:0000269|PubMed:23115192}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715,
CC ChEBI:CHEBI:57305; Evidence={ECO:0000250|UniProtKB:Q96DW6};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:23115192}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_03064}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC SLC25A38 subfamily. {ECO:0000255|HAMAP-Rule:MF_03064}.
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DR EMBL; AK078385; BAC37246.1; -; mRNA.
DR EMBL; BC010801; AAH10801.1; -; mRNA.
DR CCDS; CCDS23622.1; -.
DR RefSeq; NP_659042.1; NM_144793.1.
DR AlphaFoldDB; Q91XD8; -.
DR SMR; Q91XD8; -.
DR STRING; 10090.ENSMUSP00000035106; -.
DR iPTMnet; Q91XD8; -.
DR PhosphoSitePlus; Q91XD8; -.
DR MaxQB; Q91XD8; -.
DR PaxDb; Q91XD8; -.
DR PRIDE; Q91XD8; -.
DR ProteomicsDB; 256863; -.
DR Antibodypedia; 12178; 128 antibodies from 26 providers.
DR Ensembl; ENSMUST00000035106; ENSMUSP00000035106; ENSMUSG00000032519.
DR GeneID; 208638; -.
DR KEGG; mmu:208638; -.
DR UCSC; uc009scc.1; mouse.
DR CTD; 54977; -.
DR MGI; MGI:2384782; Slc25a38.
DR VEuPathDB; HostDB:ENSMUSG00000032519; -.
DR eggNOG; KOG0766; Eukaryota.
DR GeneTree; ENSGT00550000075117; -.
DR InParanoid; Q91XD8; -.
DR OMA; IRDAPYA; -.
DR OrthoDB; 1531343at2759; -.
DR PhylomeDB; Q91XD8; -.
DR TreeFam; TF332793; -.
DR BioGRID-ORCS; 208638; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q91XD8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q91XD8; protein.
DR Bgee; ENSMUSG00000032519; Expressed in fetal liver hematopoietic progenitor cell and 186 other tissues.
DR ExpressionAtlas; Q91XD8; baseline and differential.
DR Genevisible; Q91XD8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0015187; F:glycine transmembrane transporter activity; ISO:MGI.
DR GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR GO; GO:1904983; P:glycine import into mitochondrion; ISO:MGI.
DR Gene3D; 1.50.40.10; -; 1.
DR HAMAP; MF_03064; SLC25A38; 1.
DR InterPro; IPR030847; Hem25/SLC25A38.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..326
FT /note="Mitochondrial glycine transporter"
FT /id="PRO_0000291803"
FT TRANSMEM 51..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 109..135
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 147..172
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 200..223
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 241..267
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT TRANSMEM 296..314
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 45..134
FT /note="Solcar 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 141..225
FT /note="Solcar 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT REPEAT 237..321
FT /note="Solcar 3"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
SQ SEQUENCE 326 AA; 35390 MW; 9C895EBD7A87A9F2 CRC64;
MGVSAEPRSL SVAGAGLASP VIEKARSALL QSQDVEDTVE TLMLHPVIKA FLCGSISGTC
STLLFQPLDL LKTRLQALQP SDLGPRRVGM LAVFLKVVRT ESLLGLWKGM SPSIVRCVPG
VGIYFGTLYS SKQYFLRGHP PTALESVILG MGSRSVAGVC MSPITVIKTR YESGTYSYES
IYAALRSIYC SEGHRGLFRG LTATLLRDAP FSGLYLMFYS QTRTAVLHGT AQLDAALIPL
INFSCGIFAG VLASLVTQPA DVIKTHMQLS PVKFQWIGQA ATLIFKNHGL RGFFHGSVPR
ALRRTLMAAM AWTVYEEMMA RMGLKS
