ID   S2538_SHEEP             Reviewed;         306 AA.
AC   B2MVX9;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Mitochondrial glycine transporter {ECO:0000255|HAMAP-Rule:MF_03064};
DE   AltName: Full=Solute carrier family 25 member 38 {ECO:0000255|HAMAP-Rule:MF_03064};
GN   Name=SLC25A38 {ECO:0000255|HAMAP-Rule:MF_03064};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Deng W.;
RT   "Molecular clone and sequence analysis of SLC25A38 from black-boned sheep
RT   (Ovis aries).";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC       the mitochondrial matrix. Plays an important role in providing glycine
CC       for the first enzymatic step in heme biosynthesis, the condensation of
CC       glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC       mitochondrial matrix. Required during erythropoiesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03064}.
CC   -!- FUNCTION: Plays a role as pro-apoptotic protein that induces caspase-
CC       dependent apoptosis. {ECO:0000250|UniProtKB:Q91XD8}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715,
CC         ChEBI:CHEBI:57305; Evidence={ECO:0000250|UniProtKB:Q96DW6};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03064}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03064}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       SLC25A38 subfamily. {ECO:0000255|HAMAP-Rule:MF_03064}.
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DR   EMBL; EU626218; ACC93613.1; -; mRNA.
DR   RefSeq; NP_001120747.1; NM_001127275.1.
DR   AlphaFoldDB; B2MVX9; -.
DR   SMR; B2MVX9; -.
DR   STRING; 9940.ENSOARP00000002484; -.
DR   Ensembl; ENSOART00020027739; ENSOARP00020023006; ENSOARG00020017915.
DR   GeneID; 100147784; -.
DR   KEGG; oas:100147784; -.
DR   CTD; 54977; -.
DR   eggNOG; KOG0766; Eukaryota.
DR   OrthoDB; 1531343at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0015187; F:glycine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:1904983; P:glycine import into mitochondrion; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.50.40.10; -; 1.
DR   HAMAP; MF_03064; SLC25A38; 1.
DR   InterPro; IPR030847; Hem25/SLC25A38.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..306
FT                   /note="Mitochondrial glycine transporter"
FT                   /id="PRO_0000378920"
FT   TRANSMEM        31..56
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        89..115
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        127..152
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        180..203
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        221..247
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        276..294
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   REPEAT          25..114
FT                   /note="Solcar 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   REPEAT          121..205
FT                   /note="Solcar 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   REPEAT          217..301
FT                   /note="Solcar 3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
SQ   SEQUENCE   306 AA;  33593 MW;  6B5405C8FD54114C CRC64;
     MIQKSRPALL QHQDVGDRVE TLMLQPVIKA FLCGSISGTC STVLFQPLDL LKTRLQTLQP
     SAHGSRRVGM LALLLTVVRT ESLLGLWKGM SPSIVRCVPG VGIYFGTLYS LKQYFLRGHP
     PTALESVILG AGSRSVAGVC MSPITVIKTR YESGRYGYQS IYAALRSICH SEGFRGLFSG
     LTATLLRDAP FSGIYLMFYS QTKNVVLHST DQLDAVLVPV VNFSCGIFAG ILASLVTQPA
     DVIKTHMQLS PVKFRWIGQS VTLIFKDYGL RGFFQGSVPR ALRRTLVAAM AWTVYEEMMA
     KMGLKS