ID   S2538_XENTR             Reviewed;         302 AA.
AC   Q6DJ08;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Mitochondrial glycine transporter {ECO:0000255|HAMAP-Rule:MF_03064};
DE   AltName: Full=Solute carrier family 25 member 38 {ECO:0000255|HAMAP-Rule:MF_03064};
GN   Name=slc25a38 {ECO:0000255|HAMAP-Rule:MF_03064};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial glycine transporter that imports glycine into
CC       the mitochondrial matrix. Plays an important role in providing glycine
CC       for the first enzymatic step in heme biosynthesis, the condensation of
CC       glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the
CC       mitochondrial matrix. Required during erythropoiesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03064}.
CC   -!- FUNCTION: May play a role as pro-apoptotic protein that induces
CC       caspase-dependent apoptosis. {ECO:0000250|UniProtKB:Q91XD8}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine(in) = glycine(out); Xref=Rhea:RHEA:70715,
CC         ChEBI:CHEBI:57305; Evidence={ECO:0000250|UniProtKB:Q96DW6};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03064}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03064}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       SLC25A38 subfamily. {ECO:0000255|HAMAP-Rule:MF_03064}.
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DR   EMBL; BC075377; AAH75377.1; -; mRNA.
DR   RefSeq; NP_001004921.1; NM_001004921.1.
DR   AlphaFoldDB; Q6DJ08; -.
DR   SMR; Q6DJ08; -.
DR   STRING; 8364.ENSXETP00000000481; -.
DR   PaxDb; Q6DJ08; -.
DR   DNASU; 448302; -.
DR   Ensembl; ENSXETT00000000481; ENSXETP00000000481; ENSXETG00000000232.
DR   GeneID; 448302; -.
DR   KEGG; xtr:448302; -.
DR   CTD; 54977; -.
DR   Xenbase; XB-GENE-5814283; slc25a38.
DR   eggNOG; KOG0766; Eukaryota.
DR   HOGENOM; CLU_015166_0_3_1; -.
DR   InParanoid; Q6DJ08; -.
DR   OMA; IRDAPYA; -.
DR   OrthoDB; 1531343at2759; -.
DR   PhylomeDB; Q6DJ08; -.
DR   TreeFam; TF332793; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000232; Expressed in egg cell and 12 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0015187; F:glycine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:1904983; P:glycine import into mitochondrion; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 2.
DR   HAMAP; MF_03064; SLC25A38; 1.
DR   InterPro; IPR030847; Hem25/SLC25A38.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..302
FT                   /note="Mitochondrial glycine transporter"
FT                   /id="PRO_0000291807"
FT   TRANSMEM        28..53
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        87..113
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        125..150
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        178..201
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        217..243
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   TRANSMEM        272..290
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   REPEAT          22..112
FT                   /note="Solcar 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   REPEAT          119..203
FT                   /note="Solcar 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
FT   REPEAT          213..297
FT                   /note="Solcar 3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03064"
SQ   SEQUENCE   302 AA;  33335 MW;  6F141EF4F6AD01AD CRC64;
     MSDALVMAGE PLMSGNCFSQ MHPVFKAFVC GSLSGTCSTL LFQPLDLVKT RLQAHQLSAS
     AAGSRPRMLN LFIKVIRNEN ILGLWRGVSP SFLRCIPGVG LYFSTLYTLK HHFFSERDPK
     PLESVMLGAG SRTVAAVCML PFTVVKTRYE SGKYGYKSVY GALKNIYKTE GPRGLFSGLT
     ATLMRDAPFS GIYLMFYTRA KKLVPQDQID PLFSPVLNFG CGIVAGILAS VATQPADVIK
     THIQLSHEKC HWTGQVALNI YQNHGLTGFF RGGLPRALRR TLMAAMAWTV YEQMMEKMGL
     KS