ID   S2539_BOVIN             Reviewed;         359 AA.
AC   Q17QI7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Probable mitochondrial glutathione transporter SLC25A39 {ECO:0000305};
DE   AltName: Full=Solute carrier family 25 member 39 {ECO:0000305};
GN   Name=SLC25A39;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial transporter required for glutathione import
CC       into mitochondria. Glutathione, which plays key roles in oxidative
CC       metabolism, is produced exclusively in the cytosol and is imported in
CC       many organelles. Mitochondrial glutathione is required for the activity
CC       and stability of proteins containing iron-sulfur clusters, as well as
CC       erythropoiesis. {ECO:0000250|UniProtKB:Q9BZJ4}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q17QI7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q17QI7-2; Sequence=VSP_026022;
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC118337; AAI18338.1; -; mRNA.
DR   RefSeq; NP_001068883.1; NM_001075415.1. [Q17QI7-2]
DR   RefSeq; XP_005220900.1; XM_005220843.3. [Q17QI7-1]
DR   AlphaFoldDB; Q17QI7; -.
DR   SMR; Q17QI7; -.
DR   STRING; 9913.ENSBTAP00000025926; -.
DR   PaxDb; Q17QI7; -.
DR   PRIDE; Q17QI7; -.
DR   Ensembl; ENSBTAT00000025926; ENSBTAP00000025926; ENSBTAG00000019463. [Q17QI7-1]
DR   GeneID; 509684; -.
DR   KEGG; bta:509684; -.
DR   CTD; 51629; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019463; -.
DR   eggNOG; KOG0761; Eukaryota.
DR   GeneTree; ENSGT00940000156382; -.
DR   HOGENOM; CLU_015166_0_0_1; -.
DR   InParanoid; Q17QI7; -.
DR   OMA; DQTSVGA; -.
DR   OrthoDB; 1007936at2759; -.
DR   TreeFam; TF314720; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000019463; Expressed in diaphragm and 105 other tissues.
DR   ExpressionAtlas; Q17QI7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0160007; P:glutathione import into mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR045315; Mtm1-like.
DR   PANTHER; PTHR45760; PTHR45760; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Heme biosynthesis; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..359
FT                   /note="Probable mitochondrial glutathione transporter
FT                   SLC25A39"
FT                   /id="PRO_0000289721"
FT   TRANSMEM        15..35
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          9..151
FT                   /note="Solcar 1"
FT   REPEAT          159..243
FT                   /note="Solcar 2"
FT   REPEAT          253..347
FT                   /note="Solcar 3"
FT   VAR_SEQ         64..72
FT                   /note="LPSSLRSTG -> W (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_026022"
SQ   SEQUENCE   359 AA;  39148 MW;  BD024EB3EFA5354A CRC64;
     MADQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPSVASEL MPPSRLWSLS
     YAKLPSSLRS TGKCLLYCNG VLEPLYLCPN GARCATWFQD PTRFTGTMDA FVKIVRHEGT
     RTLWSGLPAT LVMTVPATAA YFTAYDQLKA FLCGRALTSD LYAPMVAGAL ARLGTVTVIS
     PLELVRTKLQ AQHLSYRELG TCVRAAVAQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV
     KSWLSGLRPK DQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQVALGAV EALRVMPLNT
     DSTWLLLRRI LAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKNFFQR LNREQLLSP