ID   S2539_DANRE             Reviewed;         359 AA.
AC   Q7SXW0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Probable mitochondrial glutathione transporter SLC25A39 {ECO:0000305};
DE   AltName: Full=Solute carrier family 25 member 39 {ECO:0000305};
GN   Name=slc25a39; ORFNames=zgc:63736;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19656490; DOI=10.1016/j.cmet.2009.06.012;
RA   Nilsson R., Schultz I.J., Pierce E.L., Soltis K.A., Naranuntarat A.,
RA   Ward D.M., Baughman J.M., Paradkar P.N., Kingsley P.D., Culotta V.C.,
RA   Kaplan J., Palis J., Paw B.H., Mootha V.K.;
RT   "Discovery of genes essential for heme biosynthesis through large-scale
RT   gene expression analysis.";
RL   Cell Metab. 10:119-130(2009).
CC   -!- FUNCTION: Mitochondrial transporter required for glutathione import
CC       into mitochondria. Glutathione, which plays key roles in oxidative
CC       metabolism, is produced exclusively in the cytosol and is imported in
CC       many organelles. Mitochondrial glutathione is required for the activity
CC       and stability of proteins containing iron-sulfur clusters, as well as
CC       erythropoiesis (By similarity). Involved in the early steps of heme
CC       biosynthesis (PubMed:19656490). {ECO:0000250|UniProtKB:Q9BZJ4,
CC       ECO:0000269|PubMed:19656490}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results in
CC       profound anemia without affecting erythroid specification. No porphyric
CC       phenotype detected. {ECO:0000269|PubMed:19656490}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC055226; AAH55226.1; -; mRNA.
DR   RefSeq; NP_956780.1; NM_200486.1.
DR   AlphaFoldDB; Q7SXW0; -.
DR   SMR; Q7SXW0; -.
DR   STRING; 7955.ENSDARP00000005911; -.
DR   PaxDb; Q7SXW0; -.
DR   PRIDE; Q7SXW0; -.
DR   GeneID; 393458; -.
DR   KEGG; dre:393458; -.
DR   CTD; 51629; -.
DR   ZFIN; ZDB-GENE-040426-1250; slc25a39.
DR   eggNOG; KOG0761; Eukaryota.
DR   InParanoid; Q7SXW0; -.
DR   PhylomeDB; Q7SXW0; -.
DR   PRO; PR:Q7SXW0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:ZFIN.
DR   GO; GO:0016530; F:metallochaperone activity; ISS:ZFIN.
DR   GO; GO:0160007; P:glutathione import into mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006783; P:heme biosynthetic process; IMP:ZFIN.
DR   GO; GO:0006828; P:manganese ion transport; ISS:ZFIN.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR045315; Mtm1-like.
DR   PANTHER; PTHR45760; PTHR45760; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Heme biosynthesis; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..359
FT                   /note="Probable mitochondrial glutathione transporter
FT                   SLC25A39"
FT                   /id="PRO_0000386652"
FT   TRANSMEM        19..39
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          13..149
FT                   /note="Solcar 1"
FT   REPEAT          157..241
FT                   /note="Solcar 2"
FT   REPEAT          251..346
FT                   /note="Solcar 3"
SQ   SEQUENCE   359 AA;  40113 MW;  A052E9F544B6D1E9 CRC64;
     MGDRPAVRIS AAITPVQQML ASGTGAVLTS LFVTPLDVVK IRLQAQQTPL FQAIAAESRP
     WFRVTRPSKW KCFLYCNGLM DHVYVCQNMS SCSNLYKTST HFSGTLDAFV KITHNEGLRS
     LWSGLPPTLV MAVPATVIYF TCYDQLRDFL CYSMGYHGDH IPLIAGGLAR LGAVSVISPL
     ELVRTKMQSR RLQYSELMVC IRSSVAQDGW LSLWRGWGPT VLRDVPFSAL YWFNYELVKA
     QLCEHYRTPQ ASFTISFTAG AVSGAIAAVL TLPFDVVKTR RQIQLGEMEA LGAVSMKKPS
     STWNMMRNIW IDMGYKGLFA GFLPRVIKVA PACAVMISTY EFGKTFFQER NLHQARCGL