ID   S2539_RAT               Reviewed;         359 AA.
AC   Q4V8K4;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Probable mitochondrial glutathione transporter SLC25A39 {ECO:0000305};
DE   AltName: Full=Solute carrier family 25 member 39 {ECO:0000305};
GN   Name=Slc25a39;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Mitochondrial transporter required for glutathione import
CC       into mitochondria. Glutathione, which plays key roles in oxidative
CC       metabolism, is produced exclusively in the cytosol and is imported in
CC       many organelles. Mitochondrial glutathione is required for the activity
CC       and stability of proteins containing iron-sulfur clusters, as well as
CC       erythropoiesis. {ECO:0000250|UniProtKB:Q9BZJ4}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC097349; AAH97349.1; -; mRNA.
DR   RefSeq; NP_001019963.1; NM_001024792.1.
DR   RefSeq; XP_006247436.1; XM_006247374.3.
DR   RefSeq; XP_006247438.1; XM_006247376.2.
DR   AlphaFoldDB; Q4V8K4; -.
DR   SMR; Q4V8K4; -.
DR   STRING; 10116.ENSRNOP00000028496; -.
DR   iPTMnet; Q4V8K4; -.
DR   PhosphoSitePlus; Q4V8K4; -.
DR   PaxDb; Q4V8K4; -.
DR   Ensembl; ENSRNOT00000096475; ENSRNOP00000090708; ENSRNOG00000020994.
DR   GeneID; 360636; -.
DR   KEGG; rno:360636; -.
DR   UCSC; RGD:1306193; rat.
DR   CTD; 51629; -.
DR   RGD; 1306193; Slc25a39.
DR   eggNOG; KOG0761; Eukaryota.
DR   GeneTree; ENSGT00940000156382; -.
DR   HOGENOM; CLU_015166_0_0_1; -.
DR   InParanoid; Q4V8K4; -.
DR   OMA; DQTSVGA; -.
DR   OrthoDB; 1007936at2759; -.
DR   PhylomeDB; Q4V8K4; -.
DR   TreeFam; TF314720; -.
DR   PRO; PR:Q4V8K4; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000020994; Expressed in testis and 19 other tissues.
DR   Genevisible; Q4V8K4; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0160007; P:glutathione import into mitochondrion; ISS:UniProtKB.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR045315; Mtm1-like.
DR   PANTHER; PTHR45760; PTHR45760; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Heme biosynthesis; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..359
FT                   /note="Probable mitochondrial glutathione transporter
FT                   SLC25A39"
FT                   /id="PRO_0000289722"
FT   TRANSMEM        15..35
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          9..151
FT                   /note="Solcar 1"
FT   REPEAT          159..243
FT                   /note="Solcar 2"
FT   REPEAT          253..347
FT                   /note="Solcar 3"
SQ   SEQUENCE   359 AA;  39235 MW;  FD0948440E00195E CRC64;
     MDDQDPGGIS PLQQMVASGA GAVVTSLFMT PLDVVKVRLQ SQRPTVASEL TTPSRFWSLS
     YTKSPSTLQS PGKCLLYCNG VLEPLYLCPN GTRCATWFQD PTRFTGTLDA FVKIVRHEGT
     RTLWSGLPAT LVMTVPATAI YFTAYDQLKA FLCGQSLTSD LYAPMVAGAL ARMGTVTVVS
     PLELVRTKLQ AQHVSYRELA ACVQAAVAQG GWRSLWLGWG PTALRDVPFS ALYWFNYELV
     KSQLNGPRQK EQTSVGISFV AGGISGMVAA TLTLPFDVVK TQRQMSLGAV EAMRVKPPRV
     DSTWLLLRRI QAESGTRGLF AGFLPRIIKA APSCAIMIST YEFGKSFFHR LNQEQPLGH