ID   S2540_BOVIN             Reviewed;         338 AA.
AC   Q0VCH6;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Probable mitochondrial glutathione transporter SLC25A40 {ECO:0000305};
DE   AltName: Full=Solute carrier family 25 member 40 {ECO:0000305};
GN   Name=SLC25A40 {ECO:0000250|UniProtKB:Q8TBP6};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable mitochondrial transporter required for glutathione
CC       import into mitochondria. Glutathione, which plays key roles in
CC       oxidative metabolism, is produced exclusively in the cytosol and is
CC       imported in many organelles (By similarity). Mitochondrial glutathione
CC       is required for the activity and stability of proteins containing iron-
CC       sulfur clusters, as well as erythropoiesis (By similarity).
CC       {ECO:0000250|UniProtKB:Q8BGP6, ECO:0000250|UniProtKB:Q8TBP6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC120163; AAI20164.1; -; mRNA.
DR   RefSeq; NP_001069767.1; NM_001076299.3.
DR   AlphaFoldDB; Q0VCH6; -.
DR   SMR; Q0VCH6; -.
DR   Ensembl; ENSBTAT00000047578; ENSBTAP00000044773; ENSBTAG00000054987.
DR   Ensembl; ENSBTAT00000079624; ENSBTAP00000073043; ENSBTAG00000054987.
DR   GeneID; 613948; -.
DR   KEGG; bta:613948; -.
DR   CTD; 55972; -.
DR   VEuPathDB; HostDB:ENSBTAG00000054987; -.
DR   GeneTree; ENSGT00940000160249; -.
DR   InParanoid; Q0VCH6; -.
DR   OMA; YWWGYES; -.
DR   OrthoDB; 1007936at2759; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000054987; Expressed in uterine horn and 107 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR045315; Mtm1-like.
DR   PANTHER; PTHR45760; PTHR45760; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..338
FT                   /note="Probable mitochondrial glutathione transporter
FT                   SLC25A40"
FT                   /id="PRO_0000291808"
FT   TRANSMEM        19..39
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..220
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          13..131
FT                   /note="Solcar 1"
FT   REPEAT          139..223
FT                   /note="Solcar 2"
FT   REPEAT          233..327
FT                   /note="Solcar 3"
SQ   SEQUENCE   338 AA;  38110 MW;  B71E440EBA181D40 CRC64;
     MDPESEGPAV ITVTPLQQMF ASCTGAILTS LMVTPFDVVK IRLQAQNNPF PKGKCFLYSN
     GLMDHLCVCE EEGNKAWYKK PGHFQGTLDA FLKIIRNEGI KSLWSGLPPT LVMAVPATVI
     YFTCYDQLTA LLRSKLGENE SRIPIVAGIV ARLGAVTVIS PLELIRTKMQ SKKFSYEELH
     RFVSKKVSED GWISLWRGWA PTILRDVPFS AMYWYNYEVL KKWLCAKSGL YEPTFMINFT
     SGALSGSFAA VVTLPFDVVK TQKQTQLWIY ESQKISMPLQ MSTWTIMKNI VAKNGFSGLF
     TGLIPRLIKI APACAVMIST YEFGKSFFQK QNAQRQRY