ID   S2540_DANRE             Reviewed;         353 AA.
AC   Q6DHC3;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Probable mitochondrial glutathione transporter SLC25A40 {ECO:0000305};
DE   AltName: Full=Solute carrier family 25 member 40 {ECO:0000305};
GN   Name=slc25a40 {ECO:0000250|UniProtKB:Q8TBP6};
GN   ORFNames=zgc:92520 {ECO:0000303|Ref.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable mitochondrial transporter required for glutathione
CC       import into mitochondria. Glutathione, which plays key roles in
CC       oxidative metabolism, is produced exclusively in the cytosol and is
CC       imported in many organelles (By similarity). Mitochondrial glutathione
CC       is required for the activity and stability of proteins containing iron-
CC       sulfur clusters (By similarity). {ECO:0000250|UniProtKB:Q8BGP6,
CC       ECO:0000250|UniProtKB:Q8TBP6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC076052; AAH76052.1; -; mRNA.
DR   RefSeq; NP_001002360.1; NM_001002360.1.
DR   RefSeq; XP_005158327.1; XM_005158270.3.
DR   AlphaFoldDB; Q6DHC3; -.
DR   SMR; Q6DHC3; -.
DR   STRING; 7955.ENSDARP00000011600; -.
DR   PaxDb; Q6DHC3; -.
DR   PRIDE; Q6DHC3; -.
DR   Ensembl; ENSDART00000021145; ENSDARP00000011600; ENSDARG00000015856.
DR   GeneID; 436633; -.
DR   KEGG; dre:436633; -.
DR   CTD; 55972; -.
DR   ZFIN; ZDB-GENE-040718-52; slc25a40.
DR   eggNOG; KOG0761; Eukaryota.
DR   GeneTree; ENSGT00940000165993; -.
DR   HOGENOM; CLU_015166_0_0_1; -.
DR   InParanoid; Q6DHC3; -.
DR   OMA; YWWGYES; -.
DR   OrthoDB; 1007936at2759; -.
DR   PhylomeDB; Q6DHC3; -.
DR   TreeFam; TF314720; -.
DR   PRO; PR:Q6DHC3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000015856; Expressed in mature ovarian follicle and 20 other tissues.
DR   ExpressionAtlas; Q6DHC3; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR045315; Mtm1-like.
DR   PANTHER; PTHR45760; PTHR45760; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..353
FT                   /note="Probable mitochondrial glutathione transporter
FT                   SLC25A40"
FT                   /id="PRO_0000291812"
FT   TRANSMEM        20..40
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..221
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          14..132
FT                   /note="Solcar 1"
FT   REPEAT          140..224
FT                   /note="Solcar 2"
FT   REPEAT          234..328
FT                   /note="Solcar 3"
SQ   SEQUENCE   353 AA;  39100 MW;  DFB1DC68A378B10C CRC64;
     MSCQESSPGP PGDITPFQQM MASCSGAIIT SLLVTPLDVV KIRLQAQKNP FPKGKCFVYC
     NGLMDHICVC ENGNTKVWYK APGHFSGTLD AFLKIIRMEG IRSLWSGLPP TLIMAVPATV
     IYFTCYDQLF ALLKLKMGDR SDLAPLFAGA IARVGSATVI SPLELIRTKM QSEKQSYREM
     SAVIRSALKN EGLRSLWRGW GPTLLRDVPF SAMYWFNYEK GKWWLCKRYS CSEPTVAITF
     TAGALSGSIA SIITLPFDVV KTKRQVEMGE LQTMKLSTQV SSSTCSVMKR IVAENGVSGL
     FAGFMPRLIK VAPACAIMIS TYEFGKAFFR KYNHQKEGQA TASQHIISHT EKH