ABCGH_DICDI
ID ABCGH_DICDI Reviewed; 1476 AA.
AC Q556W2; Q8T676;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=ABC transporter G family member 17;
DE AltName: Full=ABC transporter ABCG.17;
GN Name=abcG17-1; ORFNames=DDB_G0273073;
GN and
GN Name=abcG17-2; ORFNames=DDB_G0273781;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AF482395; AAL91502.1; -; Genomic_DNA.
DR EMBL; AAFI02000011; EAL70581.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70754.1; -; Genomic_DNA.
DR RefSeq; XP_644507.1; XM_639415.1.
DR RefSeq; XP_644743.1; XM_639651.1.
DR AlphaFoldDB; Q556W2; -.
DR SMR; Q556W2; -.
DR PaxDb; Q556W2; -.
DR EnsemblProtists; EAL70581; EAL70581; DDB_G0273781.
DR EnsemblProtists; EAL70754; EAL70754; DDB_G0273073.
DR GeneID; 8618843; -.
DR GeneID; 8619133; -.
DR KEGG; ddi:DDB_G0273073; -.
DR KEGG; ddi:DDB_G0273781; -.
DR dictyBase; DDB_G0273073; abcG17-1.
DR dictyBase; DDB_G0273781; abcG17-2.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_0_1; -.
DR InParanoid; Q556W2; -.
DR OMA; IAEATLC; -.
DR PhylomeDB; Q556W2; -.
DR PRO; PR:Q556W2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IGC:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Membrane; Nucleotide-binding; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1476
FT /note="ABC transporter G family member 17"
FT /id="PRO_0000391402"
FT TRANSMEM 517..537
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 547..567
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 592..612
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 623..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 764..784
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1182..1202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1219..1239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1260..1280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1298..1318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1322..1342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1450..1470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 151..402
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 507..751
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 838..1082
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1182..1405
FT /note="ABC transmembrane type-2 2"
FT REGION 13..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 14..67
FT /evidence="ECO:0000255"
FT COMPBIAS 13..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 874..881
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 2
FT /note="E -> G (in Ref. 1; AAL91502)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1476 AA; 167864 MW; A21F402F23C13892 CRC64;
MEEDKTFQSI RISENNNNNN NNNNNNNNNN NNNLNNNNDN DYDYDSINNI EEKFENVSKE
LEGQSIKFRE IDGGKNNNNH DIELGERKPE NEEDFKLRQY FEDSQRQKML INHKPKKMGV
SIKNLTVVGQ GADNSVIVDN STPFKALGKL LNPFNYFKKD KNKINTFNIL NDINAFIEDG
KMLLVLGRPG AGCSTLLRVI ANQRESYISV DGDVTYGNIA ASDWSKYRGE TLYTGEEDIH
HPTLTVRETL DFTLKLKTPG NRLPEESKRN FRTKIYELLV SMYGLVNQGD TMVGNEFVRG
LSGGERKRIT ITEAMVSGSS ITCWDCSTRG LDAASAYDYA KSLRIMSDTL DKTTIASFYQ
ASDSIYNLFD KVIVLDKGRC IYFGPIGLAK QYFLDLGFDC EPRKSTPDFL TGITNPQERI
VKVGFEGRVP ETSVDLEDAW KKSQLFQSMK HAQLEYEKQV EQQKPSVDFK EQVLNEKSRT
TSKNSEYSSS FYAQTIALTQ RQLSLTWGDK FTLTSRFLTI LVLSFIFGGI YFQQPLTTDG
LFTRGGAIFT SIIFNCILTQ GELHGALSGR RILQKHKSYA LYRPSAYFVS QILIDIPFIL
VQVFLHSFIV YFMYGFEYRA DKFFIFCFTL VGVSLSSASL FRGFANFTPS LFTAQNLMNF
VFIFEVNYFG YSQTPDKMHS WFKWTYYINP LAYAFKSLMI NEFKGLDFSC LDSAIPFDHF
NNSTYSDMSH RICAVPGSIE GSLSVKGENY LWDALQINSD HRALNVVVIF LFWLFYIGLN
LFAVEYFDWT SGGYTHKVYK RGKAPKLNDV EEERNQNQIV KKATDNMKDT LKMRGGLFSW
KSISYTVPVA GTNKLLLDDI MGWIKPGQMT ALMGSSGAGK TTLLDVLAKR KTMGTVTGES
LLNGKQLEID FERITGYVEQ MDVHNPGLTV REALRFSAKL RQEPWVPLKD KYQYVEHVLE
MMEMKHLGDA LIGTLETGVG ISVEERKRLT IGVELVAKPQ ILFLDEPTSG LDAQSSYNII
KFIRKLADAG MPLVCTIHQP SSVLFEHFDR ILLLARGGKT VYFGDIGDKS KTLTSYFERH
GVRPCTESEN PAEYILEATG AGIHGKTDVN WPEAWKQSSE YQNVVNELDL LRTKEELGKY
ILDSDLQVDG KQAPPREFAN GFLTQFIEVY KRLNIIYYRD VFYTMGSFAQ SAVSGLVIGF
TFYDLKNSSS DQQQRIFMSW EAMILGVLLI YLVLPMFFIQ KEYFKRDTAS KYYSWHAFSL
SMIAVEIPYV VLSSTLFFIA TYWTSGIDST ASANFYYWLM HTMFSVYIVS FAQALGAACV
NIAISIAALP IVLFYLFLLC GVQIPPPAMS SFYQDWLYHL NPAKYFLEGL ITTVLKPIEV
LCTDVDLIKF TAPSGTDCQT YSAPFLQQAT GYVVPLSNTT NECGYCIYSS GSDYFETSLG
WDYGHRWRNF GIIVAYWGSS ILAVLFFVYL TQKPRR
