BEND7_HUMAN
ID BEND7_HUMAN Reviewed; 519 AA.
AC Q8N7W2; Q5SYY7; Q5SYY8; Q5SYY9; Q8N5T7;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=BEN domain-containing protein 7;
GN Name=BEND7; Synonyms=C10orf30;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-324 AND SER-328, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-16; LYS-56; LYS-85 AND LYS-243,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [7]
RP VARIANT [LARGE SCALE ANALYSIS] THR-313.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- INTERACTION:
CC Q8N7W2; Q9GZT8: NIF3L1; NbExp=3; IntAct=EBI-743382, EBI-740897;
CC Q8N7W2-2; Q92688: ANP32B; NbExp=3; IntAct=EBI-10181188, EBI-762428;
CC Q8N7W2-2; Q9H503-2: BANF2; NbExp=3; IntAct=EBI-10181188, EBI-11977289;
CC Q8N7W2-2; Q13895: BYSL; NbExp=8; IntAct=EBI-10181188, EBI-358049;
CC Q8N7W2-2; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-10181188, EBI-725606;
CC Q8N7W2-2; Q16543: CDC37; NbExp=3; IntAct=EBI-10181188, EBI-295634;
CC Q8N7W2-2; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-10181188, EBI-5278764;
CC Q8N7W2-2; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-10181188, EBI-744115;
CC Q8N7W2-2; O14647: CHD2; NbExp=3; IntAct=EBI-10181188, EBI-1210503;
CC Q8N7W2-2; Q96Q77: CIB3; NbExp=3; IntAct=EBI-10181188, EBI-10292696;
CC Q8N7W2-2; P68400: CSNK2A1; NbExp=3; IntAct=EBI-10181188, EBI-347804;
CC Q8N7W2-2; P26196: DDX6; NbExp=3; IntAct=EBI-10181188, EBI-351257;
CC Q8N7W2-2; Q92997: DVL3; NbExp=5; IntAct=EBI-10181188, EBI-739789;
CC Q8N7W2-2; Q96JC9: EAF1; NbExp=3; IntAct=EBI-10181188, EBI-769261;
CC Q8N7W2-2; Q96CJ1: EAF2; NbExp=5; IntAct=EBI-10181188, EBI-1245604;
CC Q8N7W2-2; Q8N9N8: EIF1AD; NbExp=6; IntAct=EBI-10181188, EBI-750700;
CC Q8N7W2-2; P50402: EMD; NbExp=9; IntAct=EBI-10181188, EBI-489887;
CC Q8N7W2-2; Q8N9E0: FAM133A; NbExp=3; IntAct=EBI-10181188, EBI-10268158;
CC Q8N7W2-2; O95257: GADD45G; NbExp=3; IntAct=EBI-10181188, EBI-448202;
CC Q8N7W2-2; O14893: GEMIN2; NbExp=3; IntAct=EBI-10181188, EBI-443648;
CC Q8N7W2-2; Q969Y2: GTPBP3; NbExp=3; IntAct=EBI-10181188, EBI-740290;
CC Q8N7W2-2; P13807: GYS1; NbExp=3; IntAct=EBI-10181188, EBI-740553;
CC Q8N7W2-2; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-10181188, EBI-2549423;
CC Q8N7W2-2; O75031: HSF2BP; NbExp=5; IntAct=EBI-10181188, EBI-7116203;
CC Q8N7W2-2; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-10181188, EBI-2556193;
CC Q8N7W2-2; Q969R5: L3MBTL2; NbExp=8; IntAct=EBI-10181188, EBI-739909;
CC Q8N7W2-2; Q8TAP4-4: LMO3; NbExp=7; IntAct=EBI-10181188, EBI-11742507;
CC Q8N7W2-2; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-10181188, EBI-739832;
CC Q8N7W2-2; Q9NX58: LYAR; NbExp=3; IntAct=EBI-10181188, EBI-713507;
CC Q8N7W2-2; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-10181188, EBI-746778;
CC Q8N7W2-2; P55081: MFAP1; NbExp=6; IntAct=EBI-10181188, EBI-1048159;
CC Q8N7W2-2; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-10181188, EBI-8852072;
CC Q8N7W2-2; Q9UBU8: MORF4L1; NbExp=3; IntAct=EBI-10181188, EBI-399246;
CC Q8N7W2-2; Q15014: MORF4L2; NbExp=3; IntAct=EBI-10181188, EBI-399257;
CC Q8N7W2-2; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-10181188, EBI-11750983;
CC Q8N7W2-2; Q6ZUT1: NKAPD1; NbExp=6; IntAct=EBI-10181188, EBI-3920396;
CC Q8N7W2-2; Q6ZUT1-2: NKAPD1; NbExp=3; IntAct=EBI-10181188, EBI-10180231;
CC Q8N7W2-2; Q9UGY1: NOL12; NbExp=3; IntAct=EBI-10181188, EBI-716098;
CC Q8N7W2-2; P61970: NUTF2; NbExp=3; IntAct=EBI-10181188, EBI-591778;
CC Q8N7W2-2; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-10181188, EBI-9057006;
CC Q8N7W2-2; P30039: PBLD; NbExp=3; IntAct=EBI-10181188, EBI-750589;
CC Q8N7W2-2; P11309: PIM1; NbExp=3; IntAct=EBI-10181188, EBI-696621;
CC Q8N7W2-2; Q9BT43: POLR3GL; NbExp=3; IntAct=EBI-10181188, EBI-2855862;
CC Q8N7W2-2; Q13427: PPIG; NbExp=3; IntAct=EBI-10181188, EBI-396072;
CC Q8N7W2-2; O75864: PPP1R37; NbExp=3; IntAct=EBI-10181188, EBI-5235692;
CC Q8N7W2-2; O60678: PRMT3; NbExp=3; IntAct=EBI-10181188, EBI-2809009;
CC Q8N7W2-2; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-10181188, EBI-5280197;
CC Q8N7W2-2; P20618: PSMB1; NbExp=3; IntAct=EBI-10181188, EBI-372273;
CC Q8N7W2-2; Q6FGU7: RAB7L1; NbExp=3; IntAct=EBI-10181188, EBI-10249635;
CC Q8N7W2-2; P98175: RBM10; NbExp=3; IntAct=EBI-10181188, EBI-721525;
CC Q8N7W2-2; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-10181188, EBI-10226430;
CC Q8N7W2-2; P35268: RPL22; NbExp=5; IntAct=EBI-10181188, EBI-354533;
CC Q8N7W2-2; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10181188, EBI-748391;
CC Q8N7W2-2; O00560: SDCBP; NbExp=3; IntAct=EBI-10181188, EBI-727004;
CC Q8N7W2-2; P51531-2: SMARCA2; NbExp=3; IntAct=EBI-10181188, EBI-10212306;
CC Q8N7W2-2; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-10181188, EBI-12023934;
CC Q8N7W2-2; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-10181188, EBI-741515;
CC Q8N7W2-2; Q9UKI8: TLK1; NbExp=3; IntAct=EBI-10181188, EBI-740492;
CC Q8N7W2-2; O14787-2: TNPO2; NbExp=3; IntAct=EBI-10181188, EBI-12076664;
CC Q8N7W2-2; Q12899: TRIM26; NbExp=3; IntAct=EBI-10181188, EBI-2341136;
CC Q8N7W2-2; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-10181188, EBI-607755;
CC Q8N7W2-2; A0A024R8A9: USP20; NbExp=5; IntAct=EBI-10181188, EBI-14096082;
CC Q8N7W2-2; Q9Y2K6: USP20; NbExp=3; IntAct=EBI-10181188, EBI-2511991;
CC Q8N7W2-2; Q3SXR9: VCX2; NbExp=5; IntAct=EBI-10181188, EBI-11983741;
CC Q8N7W2-2; Q9P202: WHRN; NbExp=3; IntAct=EBI-10181188, EBI-310886;
CC Q8N7W2-2; Q8TBK6: ZCCHC10; NbExp=3; IntAct=EBI-10181188, EBI-597063;
CC Q8N7W2-2; Q969S3: ZNF622; NbExp=3; IntAct=EBI-10181188, EBI-2687480;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N7W2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N7W2-2; Sequence=VSP_039846, VSP_019506, VSP_019507,
CC VSP_019508;
CC Name=3;
CC IsoId=Q8N7W2-3; Sequence=VSP_039846, VSP_039847;
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DR EMBL; AK097602; BAC05114.1; -; mRNA.
DR EMBL; AL359172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031618; AAH31618.1; -; mRNA.
DR EMBL; CD300572; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS41490.1; -. [Q8N7W2-2]
DR CCDS; CCDS7099.1; -. [Q8N7W2-3]
DR RefSeq; NP_001094382.1; NM_001100912.1. [Q8N7W2-2]
DR RefSeq; NP_689964.2; NM_152751.2. [Q8N7W2-3]
DR RefSeq; XP_011517694.1; XM_011519392.2. [Q8N7W2-1]
DR RefSeq; XP_011517713.1; XM_011519411.2. [Q8N7W2-2]
DR AlphaFoldDB; Q8N7W2; -.
DR SMR; Q8N7W2; -.
DR BioGRID; 128797; 115.
DR IntAct; Q8N7W2; 87.
DR MINT; Q8N7W2; -.
DR STRING; 9606.ENSP00000345773; -.
DR iPTMnet; Q8N7W2; -.
DR PhosphoSitePlus; Q8N7W2; -.
DR BioMuta; BEND7; -.
DR DMDM; 109820782; -.
DR EPD; Q8N7W2; -.
DR jPOST; Q8N7W2; -.
DR MassIVE; Q8N7W2; -.
DR PaxDb; Q8N7W2; -.
DR PeptideAtlas; Q8N7W2; -.
DR PRIDE; Q8N7W2; -.
DR ProteomicsDB; 72335; -. [Q8N7W2-1]
DR ProteomicsDB; 72336; -. [Q8N7W2-2]
DR ProteomicsDB; 72337; -. [Q8N7W2-3]
DR Antibodypedia; 44073; 132 antibodies from 19 providers.
DR DNASU; 222389; -.
DR Ensembl; ENST00000341083.7; ENSP00000345773.3; ENSG00000165626.19. [Q8N7W2-3]
DR Ensembl; ENST00000378605.3; ENSP00000367868.3; ENSG00000165626.19. [Q8N7W2-2]
DR GeneID; 222389; -.
DR KEGG; hsa:222389; -.
DR UCSC; uc001imm.3; human. [Q8N7W2-1]
DR CTD; 222389; -.
DR DisGeNET; 222389; -.
DR GeneCards; BEND7; -.
DR HGNC; HGNC:23514; BEND7.
DR HPA; ENSG00000165626; Low tissue specificity.
DR neXtProt; NX_Q8N7W2; -.
DR OpenTargets; ENSG00000165626; -.
DR PharmGKB; PA164716578; -.
DR VEuPathDB; HostDB:ENSG00000165626; -.
DR eggNOG; ENOG502QQVD; Eukaryota.
DR GeneTree; ENSGT00940000163804; -.
DR HOGENOM; CLU_043816_1_0_1; -.
DR InParanoid; Q8N7W2; -.
DR OMA; ERYCTAN; -.
DR OrthoDB; 652532at2759; -.
DR PhylomeDB; Q8N7W2; -.
DR TreeFam; TF332993; -.
DR PathwayCommons; Q8N7W2; -.
DR SignaLink; Q8N7W2; -.
DR BioGRID-ORCS; 222389; 11 hits in 1074 CRISPR screens.
DR ChiTaRS; BEND7; human.
DR GenomeRNAi; 222389; -.
DR Pharos; Q8N7W2; Tdark.
DR PRO; PR:Q8N7W2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8N7W2; protein.
DR Bgee; ENSG00000165626; Expressed in kidney epithelium and 171 other tissues.
DR ExpressionAtlas; Q8N7W2; baseline and differential.
DR Genevisible; Q8N7W2; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR InterPro; IPR018379; BEN_domain.
DR Pfam; PF10523; BEN; 1.
DR SMART; SM01025; BEN; 1.
DR PROSITE; PS51457; BEN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..519
FT /note="BEN domain-containing protein 7"
FT /id="PRO_0000244080"
FT DOMAIN 287..392
FT /note="BEN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
FT REGION 78..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 324
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 328
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT CROSSLNK 16
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 56
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 85
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 243
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..52
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_039846"
FT VAR_SEQ 149
FT /note="N -> NGMVVNKHSEGSHG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019506"
FT VAR_SEQ 394
FT /note="S -> SA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039847"
FT VAR_SEQ 412..413
FT /note="GA -> VV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019507"
FT VAR_SEQ 414..519
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019508"
FT VARIANT 313
FT /note="R -> T (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035501"
FT VARIANT 341
FT /note="N -> S (in dbSNP:rs12247033)"
FT /id="VAR_057830"
FT CONFLICT 503
FT /note="T -> A (in Ref. 1; BAC05114)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 519 AA; 57549 MW; 28DCC0E7A21FADA8 CRC64;
MEFSERKRSR KSQSFKLVSR DYHHEVYKIP EFSNDVNGEA KETQPIFLGD ESMEIKKQIT
GMRRLLNDST GRIYQRVGKE GEKLKEEPQD LDLVWPPRLN SSAEAPQSLH PSSRGVWNEL
PPQSGQFSGQ YGTRSRTFQS QPHPTTSSNG ELPVVNSSAG SNCCTCNCQS TLQAILQELK
TMRKLMQIQA VGTQNRQQPP ISLICSQRTA VSRKRNKKKK VPPKTVEPLT VKQKPSGSEM
EKKSVVASEL SALQAAEHTS PEESRVLGFG IVLESPSSDP EVQLAEGFDV FMPKSQLDSI
LSNYTRSGSL LFRKLVCAFF DDKTLANSLP NGKRKRGLND NRKGLDQNIV GAIKVFTEKY
CTANHVDKLP GPRDWVQILQ DQIKLARRRL KRGSEIADSD ERLDGIALPP TGACGGPCTV
LPGGSAAVTL VLQSSPQTMS QEKGQMAEPW EEQHLVLLNN LTRDRAETGA LSQTSQDFKH
HSFLITQVSA TLHHQRGIRN FPTPGSAKSL TLHISCLSL
