S2540_DICDI
ID S2540_DICDI Reviewed; 366 AA.
AC Q552L9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Mitochondrial substrate carrier family protein H {ECO:0000303|PubMed:17442478};
DE AltName: Full=Solute carrier family 25 member 40 homolog {ECO:0000305};
GN Name=mcfH {ECO:0000303|PubMed:17442478}; Synonyms=slc25a40;
GN ORFNames=DDB_G0275985;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial transporter required for glutathione import
CC into mitochondria. {ECO:0000250|UniProtKB:Q9BZJ4}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69449.1; -; Genomic_DNA.
DR RefSeq; XP_643363.1; XM_638271.1.
DR AlphaFoldDB; Q552L9; -.
DR SMR; Q552L9; -.
DR STRING; 44689.DDB0237608; -.
DR PaxDb; Q552L9; -.
DR EnsemblProtists; EAL69449; EAL69449; DDB_G0275985.
DR GeneID; 8620246; -.
DR KEGG; ddi:DDB_G0275985; -.
DR dictyBase; DDB_G0275985; mcfH.
DR eggNOG; KOG0761; Eukaryota.
DR HOGENOM; CLU_015166_0_0_1; -.
DR InParanoid; Q552L9; -.
DR OMA; YVMCRIV; -.
DR PhylomeDB; Q552L9; -.
DR PRO; PR:Q552L9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR045315; Mtm1-like.
DR PANTHER; PTHR45760; PTHR45760; 2.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..366
FT /note="Mitochondrial substrate carrier family protein H"
FT /id="PRO_0000329412"
FT TRANSMEM 35..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..112
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..151
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..192
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..357
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 29..121
FT /note="Solcar 1"
FT REPEAT 132..243
FT /note="Solcar 2"
FT REPEAT 259..360
FT /note="Solcar 3"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 40633 MW; 2479A3C22ED8EE84 CRC64;
MLSNSVNNNN NNNNINNSNS NNNDSNIHKN VKKLMVASIF GGIMSSLIVT PLDVVKTRLQ
TQNTGSHINQ KHVFKGTLDA FKKIYKNEGP LTFWRGVTPS LLMTIPSATI YFTSYEYLKE
YLYQFNDTEA YNIYTVPLVA GTLARIFSAS VTSPFELLRT NSQGIVLQNA YKNTVAMAAS
SSTATIGTIP LSSEQRFNSF KLYRDIVNNV GIKGLWRGLG PTLVRDVPFS AIYWAGYEVL
KNKLMKSQID PNFSRNSKSP FFINFIAGAT SGTLAAVLTT PIDVIKTRIQ MSAQQTLSPS
LTPQQQLDFI KKNNSSIYHL KQILSQEGWK GLTKGLVPRV AKVSPACAIM ISTFEYIKQS
HIADDN
