S2540_RAT
ID S2540_RAT Reviewed; 337 AA.
AC Q498U3;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Probable mitochondrial glutathione transporter SLC25A40 {ECO:0000305};
DE AltName: Full=Solute carrier family 25 member 40 {ECO:0000305};
GN Name=Slc25a40 {ECO:0000312|RGD:1308774};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=16949250; DOI=10.1016/j.ygeno.2006.06.016;
RA Haitina T., Lindblom J., Renstroem T., Fredriksson R.;
RT "Fourteen novel human members of mitochondrial solute carrier family 25
RT (SLC25) widely expressed in the central nervous system.";
RL Genomics 88:779-790(2006).
CC -!- FUNCTION: Probable mitochondrial transporter required for glutathione
CC import into mitochondria. Glutathione, which plays key roles in
CC oxidative metabolism, is produced exclusively in the cytosol and is
CC imported in many organelles (By similarity). Mitochondrial glutathione
CC is required for the activity and stability of proteins containing iron-
CC sulfur clusters, as well as erythropoiesis (By similarity).
CC {ECO:0000250|UniProtKB:Q8BGP6, ECO:0000250|UniProtKB:Q8TBP6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q498U3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q498U3-2; Sequence=VSP_026244;
CC -!- TISSUE SPECIFICITY: Widely expressed at low level.
CC {ECO:0000269|PubMed:16949250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AABR03033761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100071; AAI00072.1; -; mRNA.
DR RefSeq; NP_001032263.1; NM_001037186.1. [Q498U3-2]
DR AlphaFoldDB; Q498U3; -.
DR SMR; Q498U3; -.
DR STRING; 10116.ENSRNOP00000058058; -.
DR PaxDb; Q498U3; -.
DR Ensembl; ENSRNOT00000061342; ENSRNOP00000058058; ENSRNOG00000022837. [Q498U3-2]
DR GeneID; 296813; -.
DR KEGG; rno:296813; -.
DR CTD; 55972; -.
DR RGD; 1308774; Slc25a40.
DR VEuPathDB; HostDB:ENSRNOG00000022837; -.
DR eggNOG; KOG0761; Eukaryota.
DR GeneTree; ENSGT00940000160249; -.
DR HOGENOM; CLU_015166_0_0_1; -.
DR InParanoid; Q498U3; -.
DR OMA; YWWGYES; -.
DR OrthoDB; 1007936at2759; -.
DR PhylomeDB; Q498U3; -.
DR PRO; PR:Q498U3; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000022837; Expressed in duodenum and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0048821; P:erythrocyte development; ISO:RGD.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR045315; Mtm1-like.
DR PANTHER; PTHR45760; PTHR45760; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..337
FT /note="Probable mitochondrial glutathione transporter
FT SLC25A40"
FT /id="PRO_0000291811"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..221
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 14..132
FT /note="Solcar 1"
FT REPEAT 140..224
FT /note="Solcar 2"
FT REPEAT 234..328
FT /note="Solcar 3"
FT VAR_SEQ 304..337
FT /note="LIPRLVKIVPACAIMISSYELGKGFFQQQNVESR -> ICLIKLSRLERCSA
FT AKSIGCSSRGSRLISQHPPGNLDLSITPVPGNLAPSPRHTCTQCAQNIVK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026244"
SQ SEQUENCE 337 AA; 38061 MW; 18DE77DB66F661ED CRC64;
MEPETEGPPP TIQVTPLQQM MASCAGAVVT SLMVTPLDVV KIRLQAQNNP FPKGKCFLYS
NGLMDHICIC EEESKKAWYK KPGNFHGTLD AFLKIVRNEG IKSLWSGLPP TLVMAVPATV
IYFTCYEQLS TFLKTKLGEN ETRIPIVAGI VARFGAVTMI SPLELIRTKM QSKTFSYKEL
YQIVSMKVSE DGWISLWKGW APTILRDVPF SAMYWYNYEN LRRWLCEKSD LYESTFMINF
TAGALSGSFA AVATLPFDVV KTQKQTQLWT HEYCKFPEPL DMSTWSIMKN IVADRGFSGL
FTGLIPRLVK IVPACAIMIS SYELGKGFFQ QQNVESR
