ID   S2540_XENLA             Reviewed;         341 AA.
AC   Q6DFK2;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Probable mitochondrial glutathione transporter SLC25A40 {ECO:0000305};
DE   AltName: Full=Solute carrier family 25 member 40 {ECO:0000305};
GN   Name=slc25a40 {ECO:0000250|UniProtKB:Q8TBP6};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable mitochondrial transporter required for glutathione
CC       import into mitochondria. Glutathione, which plays key roles in
CC       oxidative metabolism, is produced exclusively in the cytosol and is
CC       imported in many organelles (By similarity). Mitochondrial glutathione
CC       is required for the activity and stability of proteins containing iron-
CC       sulfur clusters (By similarity). {ECO:0000250|UniProtKB:Q8BGP6,
CC       ECO:0000250|UniProtKB:Q8TBP6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC076734; AAH76734.1; -; mRNA.
DR   RefSeq; NP_001086510.1; NM_001093041.1.
DR   RefSeq; XP_018122024.1; XM_018266535.1.
DR   RefSeq; XP_018122025.1; XM_018266536.1.
DR   RefSeq; XP_018122026.1; XM_018266537.1.
DR   RefSeq; XP_018122027.1; XM_018266538.1.
DR   AlphaFoldDB; Q6DFK2; -.
DR   SMR; Q6DFK2; -.
DR   DNASU; 446345; -.
DR   GeneID; 446345; -.
DR   KEGG; xla:446345; -.
DR   CTD; 446345; -.
DR   Xenbase; XB-GENE-6251490; slc25a40.L.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 446345; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR045315; Mtm1-like.
DR   PANTHER; PTHR45760; PTHR45760; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..341
FT                   /note="Probable mitochondrial glutathione transporter
FT                   SLC25A40"
FT                   /id="PRO_0000291813"
FT   TRANSMEM        20..40
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..221
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          14..132
FT                   /note="Solcar 1"
FT   REPEAT          140..224
FT                   /note="Solcar 2"
FT   REPEAT          234..328
FT                   /note="Solcar 3"
SQ   SEQUENCE   341 AA;  37977 MW;  E81B125387B1B1BF CRC64;
     MQKNTEPAQE AVHITPSQQM IASSVGALLT SFLVTPLDVV KIRLQAQSKP FIKGKCFVYC
     NGLMDHLCMC TNGNGKAWYK APGHFRGTMD AFVQIIRSEG IKSLWSGLPP TLVMAVPATV
     IYFTFYDQLR VILIRRMPER AEIASLVAGA TARLGSATLI SPLELIRTKM QYRPLSYKEL
     MICIQSSLAK DGWLSLWKGW GPTVLRDVPF SALYWHNYEL VKQSLCQRYN TLQPTFAISF
     TAGAVSGSIA AIVTLPFDVV KTRRQVEVGE LEVFTYSHKR SSSTWKLMSA IVAENGFGGL
     FAGLVPRLIK VAPACAIMIS TYEFGKSFFR KLNNERQLKS L