ID   S2540_XENTR             Reviewed;         341 AA.
AC   Q6P316;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Probable mitochondrial glutathione transporter SLC25A40 {ECO:0000305};
DE   AltName: Full=Solute carrier family 25 member 40 {ECO:0000305};
GN   Name=slc25a40 {ECO:0000250|UniProtKB:Q8TBP6};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable mitochondrial transporter required for glutathione
CC       import into mitochondria. Glutathione, which plays key roles in
CC       oxidative metabolism, is produced exclusively in the cytosol and is
CC       imported in many organelles (By similarity). Mitochondrial glutathione
CC       is required for the activity and stability of proteins containing iron-
CC       sulfur clusters (By similarity). {ECO:0000250|UniProtKB:Q8BGP6,
CC       ECO:0000250|UniProtKB:Q8TBP6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC064218; AAH64218.1; -; mRNA.
DR   EMBL; BC075453; AAH75453.1; -; mRNA.
DR   RefSeq; NP_989316.1; NM_203985.1.
DR   RefSeq; XP_012819921.1; XM_012964467.2.
DR   RefSeq; XP_017950087.1; XM_018094598.1.
DR   AlphaFoldDB; Q6P316; -.
DR   SMR; Q6P316; -.
DR   STRING; 8364.ENSXETP00000063269; -.
DR   PaxDb; Q6P316; -.
DR   DNASU; 394941; -.
DR   Ensembl; ENSXETT00000057574; ENSXETP00000057574; ENSXETG00000027655.
DR   GeneID; 394941; -.
DR   KEGG; xtr:394941; -.
DR   CTD; 55972; -.
DR   Xenbase; XB-GENE-1003942; slc25a40.
DR   eggNOG; KOG0761; Eukaryota.
DR   HOGENOM; CLU_015166_0_0_1; -.
DR   InParanoid; Q6P316; -.
DR   OrthoDB; 1007936at2759; -.
DR   PhylomeDB; Q6P316; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027655; Expressed in skeletal muscle tissue and 13 other tissues.
DR   ExpressionAtlas; Q6P316; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR045315; Mtm1-like.
DR   PANTHER; PTHR45760; PTHR45760; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..341
FT                   /note="Probable mitochondrial glutathione transporter
FT                   SLC25A40"
FT                   /id="PRO_0000291814"
FT   TRANSMEM        20..40
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..221
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          14..132
FT                   /note="Solcar 1"
FT   REPEAT          140..224
FT                   /note="Solcar 2"
FT   REPEAT          234..328
FT                   /note="Solcar 3"
SQ   SEQUENCE   341 AA;  38259 MW;  85920139D4E78C35 CRC64;
     MQKNTEPVQE AINITPSQQM IASSMGALLT SFFVTPLDVV KIRLQAQSKP FIKGKCFVYC
     NGLMDHLCLC TNGNGKAWYR APGHFRGTTD AFVQIIRNEG IKSLWSGLPP TLVMAVPATV
     IYFTCYDQLR DILIRSMPER AEIASLVAGA TARLWSATLI SPLELIRTKM QYRPLSYKEL
     RQCIQSSVAK DGWLALWKGW GPTVLRDVPF SALYWHNYEL VKQSLCQRYN TLQPTFAISF
     TAGAVSGSIA AIVTLPFDVV KTRRQVEVGE LEMFTYSQKR SSSTWKLMRA IVIENGFGGL
     FAGLIPRLIK VAPACAIMIS TYEFGKSFFR KLNNERQLKS L