ID   S2541_BOVIN             Reviewed;         349 AA.
AC   Q0II44;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Mitochondrial carrier protein SCaMC-3L {ECO:0000250|UniProtKB:Q8N5S1};
DE   AltName: Full=Mitochondrial ATP-Mg/Pi carrier protein SLC25A41 {ECO:0000305};
DE   AltName: Full=Small calcium-binding mitochondrial carrier protein 3-like;
DE            Short=SCaMC-3-like {ECO:0000250|UniProtKB:Q8BVN7};
DE            Short=SCaMC-3L {ECO:0000250|UniProtKB:Q8BVN7};
DE   AltName: Full=Solute carrier family 25 member 41;
GN   Name=SLC25A41 {ECO:0000250|UniProtKB:Q8N5S1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI22816.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus {ECO:0000312|EMBL:AAI22816.1};
RC   TISSUE=Liver {ECO:0000312|EMBL:AAI22816.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Calcium-independent ATP-Mg/Pi exchanger that catalyzes the
CC       electroneutral exchange of Mg-ATP or free ADP against an
CC       hydrogenphosphate and participates in the net transport of adenine
CC       nucleotides across the mitochondria inner membrane.
CC       {ECO:0000250|UniProtKB:Q8BVN7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in)
CC         + phosphate(out); Xref=Rhea:RHEA:65840, ChEBI:CHEBI:18420,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474;
CC         Evidence={ECO:0000250|UniProtKB:Q8BVN7};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ADP(out) + phosphate(in) = ADP(in) + phosphate(out);
CC         Xref=Rhea:RHEA:65844, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000250|UniProtKB:Q8BVN7};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q8BVN7}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O94502}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC122815; AAI22816.1; -; mRNA.
DR   RefSeq; NP_001069309.1; NM_001075841.2.
DR   AlphaFoldDB; Q0II44; -.
DR   SMR; Q0II44; -.
DR   STRING; 9913.ENSBTAP00000035802; -.
DR   PaxDb; Q0II44; -.
DR   Ensembl; ENSBTAT00000035936; ENSBTAP00000035802; ENSBTAG00000020017.
DR   GeneID; 523430; -.
DR   KEGG; bta:523430; -.
DR   CTD; 284427; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020017; -.
DR   VGNC; VGNC:34766; SLC25A41.
DR   eggNOG; KOG0036; Eukaryota.
DR   GeneTree; ENSGT00940000162419; -.
DR   HOGENOM; CLU_015166_10_2_1; -.
DR   InParanoid; Q0II44; -.
DR   OMA; VHESPPF; -.
DR   OrthoDB; 442523at2759; -.
DR   TreeFam; TF313492; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000020017; Expressed in semen and 101 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0015217; F:ADP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0005347; F:ATP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015866; P:ADP transport; ISS:UniProtKB.
DR   GO; GO:0015867; P:ATP transport; ISS:UniProtKB.
DR   GO; GO:0140021; P:mitochondrial ADP transmembrane transport; ISS:UniProtKB.
DR   GO; GO:1990544; P:mitochondrial ATP transmembrane transport; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 2.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..349
FT                   /note="Mitochondrial carrier protein SCaMC-3L"
FT                   /id="PRO_0000319989"
FT   TRANSMEM        88..104
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..168
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..205
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..261
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          88..174
FT                   /note="Solcar 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          182..267
FT                   /note="Solcar 2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   349 AA;  38571 MW;  50CF85902FA2B7C1 CRC64;
     MGAQPEQTQK PSSRVQTLFK RVKAFFTKTG PPPPPPAPSR NLGCTHVYGY VFGHLGEREP
     EHSPSQQVLD TGEQLMVPVD VLEVDNEGAL WKFLLSGAMA GAVSRTGTAP LDRAKVYMQV
     YSSKKNFMNL LGGLRSLIQE GGIRSLWRGN GINVLKIAPE YAIKFSVFEQ CKNYFCGVHE
     SPPFQERLLA GSLAVATSQT LINPMEVLKT RLTLRRTGQY KGLLDCARQI LEQEGTRALY
     RGYLPNMLGI IPYACTDLAV YEMLNCLWLK SGRDMKDPSG LVSLSSVTLS TTCGQMASYP
     LTLVRTRMQA QGQLGPFSNL AYHDPLPLLS ELSHDPPKHT QTDSQTLHI