BEND7_MOUSE
ID BEND7_MOUSE Reviewed; 434 AA.
AC Q8BSV3; Q4VAD9; Q6PHN3; Q8BPJ4; Q8C973;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=BEN domain-containing protein 7;
GN Name=Bend7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Eye, and Pituitary anterior lobe;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=FVB/N; TISSUE=Brain, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BSV3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BSV3-2; Sequence=VSP_019509;
CC Name=3;
CC IsoId=Q8BSV3-3; Sequence=VSP_019510;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH56476.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK030428; BAC26959.1; -; mRNA.
DR EMBL; AK042822; BAC31373.1; -; mRNA.
DR EMBL; AK053896; BAC35579.1; -; mRNA.
DR EMBL; BC056476; AAH56476.1; ALT_FRAME; mRNA.
DR EMBL; BC096430; AAH96430.1; -; mRNA.
DR CCDS; CCDS15658.1; -. [Q8BSV3-1]
DR CCDS; CCDS70974.1; -. [Q8BSV3-3]
DR RefSeq; NP_001177329.1; NM_001190400.1. [Q8BSV3-3]
DR RefSeq; NP_848778.1; NM_178663.4. [Q8BSV3-1]
DR AlphaFoldDB; Q8BSV3; -.
DR SMR; Q8BSV3; -.
DR STRING; 10090.ENSMUSP00000052458; -.
DR iPTMnet; Q8BSV3; -.
DR PhosphoSitePlus; Q8BSV3; -.
DR MaxQB; Q8BSV3; -.
DR PaxDb; Q8BSV3; -.
DR PRIDE; Q8BSV3; -.
DR ProteomicsDB; 273668; -. [Q8BSV3-1]
DR ProteomicsDB; 273669; -. [Q8BSV3-2]
DR ProteomicsDB; 273670; -. [Q8BSV3-3]
DR Ensembl; ENSMUST00000056914; ENSMUSP00000052458; ENSMUSG00000048186. [Q8BSV3-1]
DR Ensembl; ENSMUST00000184139; ENSMUSP00000139220; ENSMUSG00000048186. [Q8BSV3-3]
DR GeneID; 209645; -.
DR KEGG; mmu:209645; -.
DR UCSC; uc008iez.2; mouse. [Q8BSV3-1]
DR UCSC; uc008ifa.2; mouse. [Q8BSV3-3]
DR CTD; 222389; -.
DR MGI; MGI:2443100; Bend7.
DR VEuPathDB; HostDB:ENSMUSG00000048186; -.
DR eggNOG; ENOG502QQVD; Eukaryota.
DR GeneTree; ENSGT00940000163804; -.
DR InParanoid; Q8BSV3; -.
DR OMA; ERYCTAN; -.
DR PhylomeDB; Q8BSV3; -.
DR TreeFam; TF332993; -.
DR BioGRID-ORCS; 209645; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Bend7; mouse.
DR PRO; PR:Q8BSV3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BSV3; protein.
DR Bgee; ENSMUSG00000048186; Expressed in lumbar subsegment of spinal cord and 66 other tissues.
DR ExpressionAtlas; Q8BSV3; baseline and differential.
DR Genevisible; Q8BSV3; MM.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR InterPro; IPR018379; BEN_domain.
DR Pfam; PF10523; BEN; 1.
DR SMART; SM01025; BEN; 1.
DR PROSITE; PS51457; BEN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..434
FT /note="BEN domain-containing protein 7"
FT /id="PRO_0000244081"
FT DOMAIN 289..399
FT /note="BEN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
FT REGION 96..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 326
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N7W2"
FT MOD_RES 330
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N7W2"
FT CROSSLNK 16
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N7W2"
FT CROSSLNK 56
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N7W2"
FT CROSSLNK 85
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N7W2"
FT CROSSLNK 244
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N7W2"
FT VAR_SEQ 397..434
FT /note="AEVADGDERLDRISLPPTGHTFVIKRETPEDPEPGSVA -> GMNK (in
FT isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_019509"
FT VAR_SEQ 397
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_019510"
FT CONFLICT 50
FT /note="D -> H (in Ref. 1; BAC35579)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 434 AA; 48451 MW; E8FD88368BBAD642 CRC64;
MEFSERKRSR KSQSFKLVSR DYHHEVYKIS EFSNDVNGET KETQPIYLGD ESMEIKKQIT
GMRRLLNDST GRIYQRVGKE GEKLKQEPQV VDLVWPQRSN SSTEASQGLH SNSRGAWNEL
PTQSGQFSGQ SGPRSRTFQT QPHISASSNG ELPGVNSIVG SNCCTCNCQS TLQAILQELK
TMRKLMQFQA VGTQNRQQPP ISLMCSQRTA VSRKRNKKKK VLPKTVQPVT AVEPKPSPLE
TEKKPAASAT RPPGLQAAER TSTEENHVLG FGIVLESPSS DPEVQLAEGF DVFMPKSQLD
SILSNYTRSG SLLFRKLVCA FFDDKTLANS LPNGKRKRGF NDNRKGLDQN IVGAIKVFTE
NYCTANHVDK LPGPRDWVQI LQDQIKLARR RLKRGSAEVA DGDERLDRIS LPPTGHTFVI
KRETPEDPEP GSVA
