ID   S2542_DANRE             Reviewed;         321 AA.
AC   Q0P483;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Mitochondrial coenzyme A transporter SLC25A42;
DE   AltName: Full=Solute carrier family 25 member 42;
GN   Name=slc25a42; ORFNames=zgc:153304;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=26541337; DOI=10.1007/s00439-015-1608-8;
RA   Shamseldin H.E., Smith L.L., Kentab A., Alkhalidi H., Summers B.,
RA   Alsedairy H., Xiong Y., Gupta V.A., Alkuraya F.S.;
RT   "Mutation of the mitochondrial carrier SLC25A42 causes a novel form of
RT   mitochondrial myopathy in humans.";
RL   Hum. Genet. 135:21-30(2016).
CC   -!- FUNCTION: Mitochondrial carrier mediating the transport of coenzyme A
CC       (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine
CC       nucleotides and adenosine 3',5'-diphosphate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Morphant embryos show morphological anomalies
CC       including dorsal curvature and bent tails, severe muscle
CC       disorganization, early motor defects, and mitochondrial abnormalities.
CC       {ECO:0000269|PubMed:26541337}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC122225; AAI22226.1; -; mRNA.
DR   RefSeq; NP_001038918.1; NM_001045453.1.
DR   AlphaFoldDB; Q0P483; -.
DR   SMR; Q0P483; -.
DR   STRING; 7955.ENSDARP00000112426; -.
DR   PaxDb; Q0P483; -.
DR   GeneID; 751743; -.
DR   KEGG; dre:751743; -.
DR   CTD; 284439; -.
DR   ZFIN; ZDB-GENE-060825-313; slc25a42.
DR   eggNOG; KOG0752; Eukaryota.
DR   InParanoid; Q0P483; -.
DR   PhylomeDB; Q0P483; -.
DR   PRO; PR:Q0P483; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0043262; F:adenosine-diphosphatase activity; ISS:UniProtKB.
DR   GO; GO:0015217; F:ADP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0080122; F:AMP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0005347; F:ATP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015228; F:coenzyme A transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015866; P:ADP transport; ISS:UniProtKB.
DR   GO; GO:0080121; P:AMP transport; ISS:UniProtKB.
DR   GO; GO:0015867; P:ATP transport; ISS:UniProtKB.
DR   GO; GO:0035349; P:coenzyme A transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0007006; P:mitochondrial membrane organization; IMP:ZFIN.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002167; Graves_DC.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00928; GRAVESDC.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..321
FT                   /note="Mitochondrial coenzyme A transporter SLC25A42"
FT                   /id="PRO_0000291820"
FT   TRANSMEM        35..55
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..154
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..208
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          33..119
FT                   /note="Solcar 1"
FT   REPEAT          131..216
FT                   /note="Solcar 2"
FT   REPEAT          226..314
FT                   /note="Solcar 3"
SQ   SEQUENCE   321 AA;  35336 MW;  16285B1BADDB42C8 CRC64;
     MGNVVQERQG ALAQGEVLPR PAASQSEGFK QGRSVLNSLV SGAFAGAVAK TAVAPLDRTK
     IIFQVSSNRF SAKEAYRLIY RTYLKDGFFS LWRGNSATMV RVIPYAAIQF CAHEQYKGIL
     GKYYGFQGKA LPPVPRLLAG SLAGTTAAII TYPLDMVRAR MAVTPKEMYS NIMDVFVRIS
     REEGLKTLYR GFTPTILGVV PYAGLSFFTY ETLKKTHAEK TGRAHPFPYE RLVFGACAGL
     IGQSASYPLD VVRRRMQTAG VTGHTYSTVL GTMREIVAEE GIVRGLYKGL SMNWVKGPIA
     VGISFMTFDL TQILLRKFQL L