S2542_MOUSE
ID S2542_MOUSE Reviewed; 318 AA.
AC Q8R0Y8;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Mitochondrial coenzyme A transporter SLC25A42;
DE AltName: Full=Solute carrier family 25 member 42;
GN Name=Slc25a42;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Mitochondrial carrier mediating the transport of coenzyme A
CC (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine
CC nucleotides and adenosine 3',5'-diphosphate. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC025937; AAH25937.1; -; mRNA.
DR EMBL; BC036140; AAH36140.1; -; mRNA.
DR CCDS; CCDS40370.1; -.
DR RefSeq; NP_001007571.1; NM_001007570.2.
DR AlphaFoldDB; Q8R0Y8; -.
DR SMR; Q8R0Y8; -.
DR BioGRID; 215767; 2.
DR IntAct; Q8R0Y8; 1.
DR STRING; 10090.ENSMUSP00000105754; -.
DR iPTMnet; Q8R0Y8; -.
DR PhosphoSitePlus; Q8R0Y8; -.
DR SwissPalm; Q8R0Y8; -.
DR EPD; Q8R0Y8; -.
DR jPOST; Q8R0Y8; -.
DR MaxQB; Q8R0Y8; -.
DR PaxDb; Q8R0Y8; -.
DR PeptideAtlas; Q8R0Y8; -.
DR PRIDE; Q8R0Y8; -.
DR ProteomicsDB; 256866; -.
DR Antibodypedia; 28336; 41 antibodies from 15 providers.
DR DNASU; 73095; -.
DR Ensembl; ENSMUST00000063788; ENSMUSP00000065903; ENSMUSG00000002346.
DR Ensembl; ENSMUST00000110127; ENSMUSP00000105754; ENSMUSG00000002346.
DR GeneID; 73095; -.
DR KEGG; mmu:73095; -.
DR UCSC; uc009lzg.2; mouse.
DR CTD; 284439; -.
DR MGI; MGI:1920345; Slc25a42.
DR VEuPathDB; HostDB:ENSMUSG00000002346; -.
DR eggNOG; KOG0752; Eukaryota.
DR GeneTree; ENSGT00940000158163; -.
DR HOGENOM; CLU_015166_10_1_1; -.
DR InParanoid; Q8R0Y8; -.
DR OMA; VYERMKW; -.
DR OrthoDB; 1253450at2759; -.
DR PhylomeDB; Q8R0Y8; -.
DR TreeFam; TF314806; -.
DR BioGRID-ORCS; 73095; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Slc25a42; mouse.
DR PRO; PR:Q8R0Y8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R0Y8; protein.
DR Bgee; ENSMUSG00000002346; Expressed in interventricular septum and 175 other tissues.
DR Genevisible; Q8R0Y8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; HDA:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0043262; F:adenosine-diphosphatase activity; ISS:UniProtKB.
DR GO; GO:0015217; F:ADP transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0080122; F:AMP transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015228; F:coenzyme A transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015866; P:ADP transport; ISS:UniProtKB.
DR GO; GO:0080121; P:AMP transport; ISS:UniProtKB.
DR GO; GO:0015867; P:ATP transport; ISS:UniProtKB.
DR GO; GO:0035349; P:coenzyme A transmembrane transport; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..318
FT /note="Mitochondrial coenzyme A transporter SLC25A42"
FT /id="PRO_0000291818"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 31..117
FT /note="Solcar 1"
FT REPEAT 129..214
FT /note="Solcar 2"
FT REPEAT 224..312
FT /note="Solcar 3"
SQ SEQUENCE 318 AA; 35241 MW; 283500D1C41199BD CRC64;
MGNGVQEGSV RLREDAEAVL AGAVSSKRDH RQVLSSLLSG ALAGALAKTA VAPLDRTKII
FQVSSKRFSA KEAFRLLYFT YLNEGFLSLW RGNSATMVRV IPYAAIQFSA HEEYKRILGH
YYGFRGEALP PWPRLLAGAL AGTTAASLTY PLDLVRARMA VTPKEMYSNI FHVFIRISRE
EGLKTLYFGF TPTVLGVIPY AGLSFFTYES LKSLHREYSG RPQPYPFERM VFGACAGLIG
QSASYPLDVV RRRMQTAGVT GHQHGSILST LRSIVREEGA VRGLYKGLSM NWLKGPIAVG
ISFTTFDLMQ ILLRRLQS
