ID   S2542_XENLA             Reviewed;         327 AA.
AC   Q5PQ27;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Mitochondrial coenzyme A transporter SLC25A42;
DE   AltName: Full=Solute carrier family 25 member 42;
GN   Name=slc25a42;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial carrier mediating the transport of coenzyme A
CC       (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine
CC       nucleotides and adenosine 3',5'-diphosphate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC087392; AAH87392.1; -; mRNA.
DR   RefSeq; NP_001088738.1; NM_001095269.1.
DR   AlphaFoldDB; Q5PQ27; -.
DR   SMR; Q5PQ27; -.
DR   DNASU; 496002; -.
DR   GeneID; 496002; -.
DR   KEGG; xla:496002; -.
DR   CTD; 496002; -.
DR   Xenbase; XB-GENE-5933612; slc25a42.S.
DR   OrthoDB; 1253450at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 496002; Expressed in muscle tissue and 13 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0043262; F:adenosine-diphosphatase activity; ISS:UniProtKB.
DR   GO; GO:0015217; F:ADP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0080122; F:AMP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0005347; F:ATP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015228; F:coenzyme A transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015866; P:ADP transport; ISS:UniProtKB.
DR   GO; GO:0080121; P:AMP transport; ISS:UniProtKB.
DR   GO; GO:0015867; P:ATP transport; ISS:UniProtKB.
DR   GO; GO:0035349; P:coenzyme A transmembrane transport; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002167; Graves_DC.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00928; GRAVESDC.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..327
FT                   /note="Mitochondrial coenzyme A transporter SLC25A42"
FT                   /id="PRO_0000291821"
FT   TRANSMEM        36..56
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..209
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          34..120
FT                   /note="Solcar 1"
FT   REPEAT          132..217
FT                   /note="Solcar 2"
FT   REPEAT          227..315
FT                   /note="Solcar 3"
SQ   SEQUENCE   327 AA;  36062 MW;  23D93F4FA802A3B8 CRC64;
     MENGIKESPV GLNKNGALAI LPTPLVSEGH KNHKSVLNSL TSGALAGAVA KTAVAPLDRT
     KIIFQVSSNR FSAKEAYRLI YRTYMNDGFL SLWRGNSATM VRVIPYAAIQ FCAHEQYKKL
     LGSYYGFQGS ALTPIPRLLA GALAGTTATL LTYPLDLVRA RMAVTQKEMY SNIIHVFMRM
     SREEGLKSLY RGFTPTVLGV IPYAGISFFT YETLKKLHAE HSGRTQPYTF ERLLFGACAG
     LFGQSSSYPL DVVRRRMQTA GVTGHTYGSI IGTMQEIVAE EGFIRGLYKG LSMNWVKGPV
     AVGISFTTFD LTQILLKKLQ QISHIQR