ID   S2542_XENTR             Reviewed;         327 AA.
AC   Q05AQ3;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Mitochondrial coenzyme A transporter SLC25A42;
DE   AltName: Full=Solute carrier family 25 member 42;
GN   Name=slc25a42;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Skin;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial carrier mediating the transport of coenzyme A
CC       (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine
CC       nucleotides and adenosine 3',5'-diphosphate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC124065; AAI24066.1; -; mRNA.
DR   RefSeq; NP_001072712.1; NM_001079244.1.
DR   RefSeq; XP_012821282.1; XM_012965828.2.
DR   AlphaFoldDB; Q05AQ3; -.
DR   SMR; Q05AQ3; -.
DR   STRING; 8364.ENSXETP00000031355; -.
DR   PaxDb; Q05AQ3; -.
DR   GeneID; 780169; -.
DR   KEGG; xtr:780169; -.
DR   CTD; 284439; -.
DR   Xenbase; XB-GENE-5933592; slc25a42.
DR   eggNOG; KOG0752; Eukaryota.
DR   HOGENOM; CLU_015166_10_1_1; -.
DR   InParanoid; Q05AQ3; -.
DR   OrthoDB; 1253450at2759; -.
DR   PhylomeDB; Q05AQ3; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014336; Expressed in skeletal muscle tissue and 12 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0043262; F:adenosine-diphosphatase activity; ISS:UniProtKB.
DR   GO; GO:0015217; F:ADP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0080122; F:AMP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0005347; F:ATP transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015228; F:coenzyme A transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015866; P:ADP transport; ISS:UniProtKB.
DR   GO; GO:0080121; P:AMP transport; ISS:UniProtKB.
DR   GO; GO:0015867; P:ATP transport; ISS:UniProtKB.
DR   GO; GO:0035349; P:coenzyme A transmembrane transport; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002167; Graves_DC.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00928; GRAVESDC.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..327
FT                   /note="Mitochondrial coenzyme A transporter SLC25A42"
FT                   /id="PRO_0000291822"
FT   TRANSMEM        36..56
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          34..120
FT                   /note="Solcar 1"
FT   REPEAT          132..217
FT                   /note="Solcar 2"
FT   REPEAT          227..315
FT                   /note="Solcar 3"
SQ   SEQUENCE   327 AA;  36036 MW;  9B7B39C597B9B208 CRC64;
     MENGIKESQV GLNKNGTHAI LPSPVVSEGH KNHKSILNSL MSGALAGAVA KTAVAPLDRT
     KIIFQVSSNR FSAKEAYRLI YRTYLNEGFL SLWRGNSATM VRVIPYAAIQ FCAHEQYKKL
     LGSYYGFQGS ALTPIPRLLA GALAGTTATI ITYPLDLVRA RMAVTPKEMY SNIIHVFMRM
     SREEGLKSLY RGFTPTVLGV IPYAGISFFT YETLKKLHAE HSGRTQPYPF ERLLFGACAG
     LFGQSASYPL DVVRRRMQTA GVTGHAYGSI IGTMQEIVAE EGVIRGLYKG LSMNWVKGPV
     AVGISFTTFD LTQILLKKLQ RLSDIQR