ID   S2543_MOUSE             Reviewed;         341 AA.
AC   A2A3V2; B2RWC0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Solute carrier family 25 member 43;
GN   Name=Slc25a43; Synonyms=Gm8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AL450397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC147709; AAI47710.1; -; mRNA.
DR   EMBL; BC147717; AAI47718.1; -; mRNA.
DR   CCDS; CCDS40925.1; -.
DR   RefSeq; NP_001078966.1; NM_001085497.2.
DR   AlphaFoldDB; A2A3V2; -.
DR   SMR; A2A3V2; -.
DR   STRING; 10090.ENSMUSP00000035392; -.
DR   iPTMnet; A2A3V2; -.
DR   PhosphoSitePlus; A2A3V2; -.
DR   PaxDb; A2A3V2; -.
DR   PRIDE; A2A3V2; -.
DR   ProteomicsDB; 260764; -.
DR   Antibodypedia; 29773; 19 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000047655; ENSMUSP00000035392; ENSMUSG00000037636.
DR   GeneID; 194744; -.
DR   KEGG; mmu:194744; -.
DR   UCSC; uc009sxr.2; mouse.
DR   CTD; 203427; -.
DR   MGI; MGI:2684854; Slc25a43.
DR   VEuPathDB; HostDB:ENSMUSG00000037636; -.
DR   eggNOG; KOG0752; Eukaryota.
DR   GeneTree; ENSGT00940000160686; -.
DR   HOGENOM; CLU_015166_10_3_1; -.
DR   InParanoid; A2A3V2; -.
DR   OMA; YPTDMVK; -.
DR   OrthoDB; 1253450at2759; -.
DR   PhylomeDB; A2A3V2; -.
DR   TreeFam; TF354298; -.
DR   BioGRID-ORCS; 194744; 2 hits in 71 CRISPR screens.
DR   PRO; PR:A2A3V2; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; A2A3V2; protein.
DR   Bgee; ENSMUSG00000037636; Expressed in yolk sac and 54 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..341
FT                   /note="Solute carrier family 25 member 43"
FT                   /id="PRO_0000291824"
FT   TRANSMEM        16..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          11..101
FT                   /note="Solcar 1"
FT   REPEAT          105..185
FT                   /note="Solcar 2"
FT   REPEAT          200..298
FT                   /note="Solcar 3"
SQ   SEQUENCE   341 AA;  38064 MW;  FA60DED0FAD3439F CRC64;
     MATWRRDGRL TGSQRLLCAG LAGAFSLSLT APLELATVLA QVGKVQSHSL GLWATGRRVW
     LSEGPRALWK GNGVACLRLF PCSMVQLAAY RKFVVLFMDD LGRISQWSSI VTGSLAGMVS
     TIVTYPTDLI KTRLMVQNVL EPSYRGLIHA FSTIYQQEGF LALYRGVSLT VLGAVPFSAG
     SLLVYMNLEK VWNGPRDRFS HLQNFANVCV AAAVSQTLSF PFDTVKRKMQ AQSPYLPHYG
     GVDVHFSGAA DCFRQIVKTQ GVLGLWNGLT ANLLKVVPYF GVMFSMFEFC KRIFLYQNGY
     TLSPLTYKLT PGVDQSLKPQ ELRELKKFFK RRKLHSKTPP W