ID   S2544_PONAB             Reviewed;         314 AA.
AC   Q5RD67; Q5R7X7;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Solute carrier family 25 member 44;
GN   Name=SLC25A44 {ECO:0000250|UniProtKB:Q8BGF9};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial solute transporter which transports branched-
CC       chain amino acid (BCAA; valine, leucine and isoleucine) into
CC       mitochondria in brown adipose tissue (BAT). BAT is involved in BCAA
CC       catabolism and actively utilizes BCAA in the mitochondria for
CC       thermogenesis. {ECO:0000250|UniProtKB:Q8BGF9}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q8BGF9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000255}.
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DR   EMBL; CR858050; CAH90290.1; -; mRNA.
DR   EMBL; CR859982; CAH92133.1; -; mRNA.
DR   RefSeq; NP_001125132.1; NM_001131660.1.
DR   AlphaFoldDB; Q5RD67; -.
DR   SMR; Q5RD67; -.
DR   Ensembl; ENSPPYT00000000873; ENSPPYP00000000842; ENSPPYG00000000726.
DR   GeneID; 100172017; -.
DR   KEGG; pon:100172017; -.
DR   CTD; 9673; -.
DR   GeneTree; ENSGT00940000155399; -.
DR   InParanoid; Q5RD67; -.
DR   OrthoDB; 1102784at2759; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0015658; F:branched-chain amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0009083; P:branched-chain amino acid catabolic process; ISS:UniProtKB.
DR   GO; GO:0015803; P:branched-chain amino acid transport; ISS:UniProtKB.
DR   GO; GO:0120161; P:regulation of cold-induced thermogenesis; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   InterPro; IPR042164; SLC25A44.
DR   PANTHER; PTHR46314; PTHR46314; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Membrane; Mitochondrion; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..314
FT                   /note="Solute carrier family 25 member 44"
FT                   /id="PRO_0000253066"
FT   TRANSMEM        20..42
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..90
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..201
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..239
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..296
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          18..100
FT                   /note="Solcar 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT   REPEAT          107..210
FT                   /note="Solcar 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT   REPEAT          220..302
FT                   /note="Solcar 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT   CONFLICT        142
FT                   /note="K -> R (in Ref. 1; CAH90290)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        209
FT                   /note="E -> G (in Ref. 1; CAH92133)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   314 AA;  35420 MW;  978889AD1F6334DF CRC64;
     MEDKRNIQII EWEHLDKKKF YVFGVAMTMM IRVSVYPFTL IRTRLQVQKG KSLYHGTFDA
     FIKILRADGI TGLYRGFLVN TFTLISGQCY VTTYELTRKF VADYSQSNTV KSLVAGGSAS
     LVAQSITVPI DVVSQHLMMQ RKGEKMGRFQ VRGNPEGQGV VAFGQTKDII RQILRADGLR
     GFYRGYVASL LTYIPNSAVW WPFYHFYAEQ LSYLCPKECP HIVFQAVSGP LAAATASILT
     NPMDVIRTRV QVEGKNSIIL TFRQLMAEEG PWGLMKGLSA RIISATPSTI VIVVGYESLK
     KLSLRPELVD SRHW