S2545_HUMAN
ID S2545_HUMAN Reviewed; 288 AA.
AC Q8N413; Q6PL49; Q8IW29;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Solute carrier family 25 member 45;
GN Name=SLC25A45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND VARIANT VAL-224.
RA Lin L., Zhong G., Ke R., Li H., Zhou G., Shen C., Yang S.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND VARIANT
RP VAL-224.
RC TISSUE=Pancreas, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=16949250; DOI=10.1016/j.ygeno.2006.06.016;
RA Haitina T., Lindblom J., Renstroem T., Fredriksson R.;
RT "Fourteen novel human members of mitochondrial solute carrier family 25
RT (SLC25) widely expressed in the central nervous system.";
RL Genomics 88:779-790(2006).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N413-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N413-2; Sequence=VSP_026246;
CC Name=3;
CC IsoId=Q8N413-3; Sequence=VSP_026246, VSP_026248;
CC Name=4;
CC IsoId=Q8N413-4; Sequence=VSP_026247;
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION: [Isoform 4]:
CC Sequence=BC041100; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY597807; AAT09000.1; -; mRNA.
DR EMBL; AP000944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036869; AAH36869.1; -; mRNA.
DR EMBL; BC041100; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS41670.1; -. [Q8N413-1]
DR CCDS; CCDS41671.1; -. [Q8N413-2]
DR CCDS; CCDS60850.1; -. [Q8N413-4]
DR RefSeq; NP_001070709.2; NM_001077241.2. [Q8N413-2]
DR RefSeq; NP_001265179.2; NM_001278250.2. [Q8N413-4]
DR RefSeq; NP_001265180.2; NM_001278251.2. [Q8N413-2]
DR RefSeq; NP_001287749.1; NM_001300820.1.
DR RefSeq; NP_872362.3; NM_182556.3. [Q8N413-1]
DR RefSeq; XP_006718572.1; XM_006718509.3.
DR RefSeq; XP_006718573.1; XM_006718510.3.
DR RefSeq; XP_011543245.1; XM_011544943.2.
DR RefSeq; XP_011543246.1; XM_011544944.2.
DR RefSeq; XP_011543251.1; XM_011544949.2.
DR RefSeq; XP_016873052.1; XM_017017563.1.
DR RefSeq; XP_016873053.1; XM_017017564.1.
DR RefSeq; XP_016873054.1; XM_017017565.1.
DR RefSeq; XP_016873055.1; XM_017017566.1.
DR RefSeq; XP_016873056.1; XM_017017567.1.
DR RefSeq; XP_016873057.1; XM_017017568.1.
DR RefSeq; XP_016873058.1; XM_017017569.1.
DR RefSeq; XP_016873059.1; XM_017017570.1.
DR RefSeq; XP_016873060.1; XM_017017571.1.
DR AlphaFoldDB; Q8N413; -.
DR SMR; Q8N413; -.
DR BioGRID; 129470; 1.
DR STRING; 9606.ENSP00000381782; -.
DR TCDB; 2.A.29.8.7; the mitochondrial carrier (mc) family.
DR BioMuta; SLC25A45; -.
DR DMDM; 150416125; -.
DR MassIVE; Q8N413; -.
DR PaxDb; Q8N413; -.
DR PeptideAtlas; Q8N413; -.
DR PRIDE; Q8N413; -.
DR ProteomicsDB; 71861; -. [Q8N413-1]
DR ProteomicsDB; 71862; -. [Q8N413-2]
DR Antibodypedia; 7360; 39 antibodies from 19 providers.
DR DNASU; 283130; -.
DR Ensembl; ENST00000294187.10; ENSP00000294187.6; ENSG00000162241.13. [Q8N413-2]
DR Ensembl; ENST00000398802.6; ENSP00000381782.1; ENSG00000162241.13. [Q8N413-1]
DR Ensembl; ENST00000527174.5; ENSP00000435489.1; ENSG00000162241.13. [Q8N413-1]
DR Ensembl; ENST00000534028.5; ENSP00000431769.1; ENSG00000162241.13. [Q8N413-4]
DR GeneID; 283130; -.
DR KEGG; hsa:283130; -.
DR MANE-Select; ENST00000398802.6; ENSP00000381782.1; NM_182556.4; NP_872362.4.
DR UCSC; uc001odq.3; human. [Q8N413-1]
DR CTD; 283130; -.
DR DisGeNET; 283130; -.
DR GeneCards; SLC25A45; -.
DR HGNC; HGNC:27442; SLC25A45.
DR HPA; ENSG00000162241; Tissue enhanced (pancreas).
DR MIM; 610825; gene.
DR neXtProt; NX_Q8N413; -.
DR OpenTargets; ENSG00000162241; -.
DR PharmGKB; PA162403718; -.
DR VEuPathDB; HostDB:ENSG00000162241; -.
DR eggNOG; KOG0758; Eukaryota.
DR GeneTree; ENSGT00940000161002; -.
DR InParanoid; Q8N413; -.
DR OMA; MQTAPKG; -.
DR OrthoDB; 1072378at2759; -.
DR PhylomeDB; Q8N413; -.
DR TreeFam; TF351739; -.
DR PathwayCommons; Q8N413; -.
DR BioGRID-ORCS; 283130; 17 hits in 1070 CRISPR screens.
DR ChiTaRS; SLC25A45; human.
DR GenomeRNAi; 283130; -.
DR Pharos; Q8N413; Tdark.
DR PRO; PR:Q8N413; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8N413; protein.
DR Bgee; ENSG00000162241; Expressed in body of pancreas and 135 other tissues.
DR ExpressionAtlas; Q8N413; baseline and differential.
DR Genevisible; Q8N413; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..288
FT /note="Solute carrier family 25 member 45"
FT /id="PRO_0000291826"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 1..83
FT /note="Solcar 1"
FT REPEAT 97..191
FT /note="Solcar 2"
FT REPEAT 199..286
FT /note="Solcar 3"
FT VAR_SEQ 1..42
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_026246"
FT VAR_SEQ 28..51
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026247"
FT VAR_SEQ 52..113
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_026248"
FT VARIANT 224
FT /note="M -> V (in dbSNP:rs624307)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_032866"
FT VARIANT 251
FT /note="R -> Q (in dbSNP:rs7108281)"
FT /id="VAR_050135"
FT CONFLICT 153
FT /note="S -> P (in Ref. 1; AAT09000)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 288 AA; 31906 MW; BD8EF1D8A2BFB296 CRC64;
MPVEEFVAGW ISGALGLVLG HPFDTVKVRL QTQTTYRGIV DCMVKIYRHE SLLGFFKGMS
FPIASIAVVN SVLFGVYSNT LLVLTATSHQ ERRAQPPSYM HIFLAGCTGG FLQAYCLAPF
DLIKVRLQNQ TEPRAQPGSP PPRYQGPVHC AASIFREEGP RGLFRGAWAL TLRDTPTVGI
YFITYEGLCR QYTPEGQNPS SATVLVAGGF AGIASWVAAT PLDMIKSRMQ MDGLRRRVYQ
GMLDCMVSSI RQEGLGVFFR GVTINSARAF PVNAVTFLSY EYLLRWWG
