S2545_MOUSE
ID S2545_MOUSE Reviewed; 288 AA.
AC Q8CFJ7; Q3TC75; Q3UZE9; Q8VBZ7;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Solute carrier family 25 member 45;
GN Name=Slc25a45;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Liver, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=19287344; DOI=10.1203/pdr.0b013e3181a283c1;
RA Camacho J.A., Rioseco-Camacho N.;
RT "The human and mouse SLC25A29 mitochondrial transporters rescue the
RT deficient ornithine metabolism in fibroblasts of patients with the
RT hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.";
RL Pediatr. Res. 66:35-41(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CFJ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CFJ7-2; Sequence=VSP_026250, VSP_026251;
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in testis,
CC liver and kidney and low levels in brain, including cortex, cerebellum,
CC hippocampus and hypothalamus, and heart. {ECO:0000269|PubMed:19287344}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH22156.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE42082.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK133879; BAE21908.1; -; mRNA.
DR EMBL; AK155754; BAE33419.1; -; mRNA.
DR EMBL; AK169876; BAE41428.1; -; mRNA.
DR EMBL; AK170869; BAE42082.1; ALT_FRAME; mRNA.
DR EMBL; BC022156; AAH22156.1; ALT_INIT; mRNA.
DR EMBL; BC037680; AAH37680.1; -; mRNA.
DR CCDS; CCDS29482.1; -. [Q8CFJ7-1]
DR RefSeq; NP_598915.1; NM_134154.3. [Q8CFJ7-1]
DR RefSeq; XP_006531684.1; XM_006531621.3.
DR AlphaFoldDB; Q8CFJ7; -.
DR SMR; Q8CFJ7; -.
DR BioGRID; 223254; 1.
DR STRING; 10090.ENSMUSP00000025732; -.
DR SwissPalm; Q8CFJ7; -.
DR EPD; Q8CFJ7; -.
DR jPOST; Q8CFJ7; -.
DR MaxQB; Q8CFJ7; -.
DR PaxDb; Q8CFJ7; -.
DR PeptideAtlas; Q8CFJ7; -.
DR PRIDE; Q8CFJ7; -.
DR ProteomicsDB; 260766; -. [Q8CFJ7-1]
DR ProteomicsDB; 260767; -. [Q8CFJ7-2]
DR Antibodypedia; 7360; 39 antibodies from 19 providers.
DR DNASU; 107375; -.
DR Ensembl; ENSMUST00000025732; ENSMUSP00000025732; ENSMUSG00000024818. [Q8CFJ7-1]
DR Ensembl; ENSMUST00000125114; ENSMUSP00000122076; ENSMUSG00000024818. [Q8CFJ7-2]
DR Ensembl; ENSMUST00000155697; ENSMUSP00000121596; ENSMUSG00000024818. [Q8CFJ7-1]
DR GeneID; 107375; -.
DR KEGG; mmu:107375; -.
DR UCSC; uc008gfq.1; mouse. [Q8CFJ7-1]
DR UCSC; uc008gfr.1; mouse. [Q8CFJ7-2]
DR CTD; 283130; -.
DR MGI; MGI:2147731; Slc25a45.
DR VEuPathDB; HostDB:ENSMUSG00000024818; -.
DR eggNOG; KOG0758; Eukaryota.
DR GeneTree; ENSGT00940000161002; -.
DR HOGENOM; CLU_015166_16_1_1; -.
DR InParanoid; Q8CFJ7; -.
DR OMA; MQTAPKG; -.
DR OrthoDB; 1072378at2759; -.
DR PhylomeDB; Q8CFJ7; -.
DR TreeFam; TF351739; -.
DR BioGRID-ORCS; 107375; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8CFJ7; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8CFJ7; protein.
DR Bgee; ENSMUSG00000024818; Expressed in small intestine Peyer's patch and 143 other tissues.
DR ExpressionAtlas; Q8CFJ7; baseline and differential.
DR Genevisible; Q8CFJ7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..288
FT /note="Solute carrier family 25 member 45"
FT /id="PRO_0000291827"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 1..83
FT /note="Solcar 1"
FT REPEAT 97..191
FT /note="Solcar 2"
FT REPEAT 199..286
FT /note="Solcar 3"
FT VAR_SEQ 201..212
FT /note="SATVLVAGGFAG -> KWGEVGWGGGTA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026250"
FT VAR_SEQ 213..288
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026251"
SQ SEQUENCE 288 AA; 31690 MW; D86B0DE50886A11A CRC64;
MPVEEFVAGW ISGAVGLVLG HPFDTVKVRL QTQSTYQGIV DCVVKTYRHE SVLGFFKGMS
FPIASVALVN SVLFGVYSNT LLALTATSHQ ERRAQPPSYT NIFIAGCTGG LLQAYCLAPF
DLIKVRLQNQ TEPRMQISSS MPRYRGPVHC AASILREEGP QGLFRGSWAL VLRDTPTLGM
YFVTYEGLCR QYTPEGQNPS SATVLVAGGF AGIASWITAT PFDVIKSRMQ MDGLKGRKYG
GMLDCMASSF RQEGIGVFFK GMTLNSARAF PVNAATFLSY EYLLRLWR
